{"id":"https://openalex.org/W2000939390","doi":"https://doi.org/10.1186/1479-7364-4-4-226","title":"From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery","display_name":"From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2000939390","doi":"https://doi.org/10.1186/1479-7364-4-4-226","mag":"2000939390","pmid":"https://pubmed.ncbi.nlm.nih.gov/20511136","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2976604"},"language":"en","primary_location":{"id":"doi:10.1186/1479-7364-4-4-226","doi":"https://doi.org/10.1186/1479-7364-4-4-226","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-7364-4-4-226","pdf_url":"https://humgenomics.biomedcentral.com/counter/pdf/10.1186/1479-7364-4-4-226","source":{"id":"https://openalex.org/S2738571386","display_name":"Human Genomics","issn_l":"1473-9542","issn":["1473-9542","1479-7364"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genomics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://humgenomics.biomedcentral.com/counter/pdf/10.1186/1479-7364-4-4-226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014631856","display_name":"Xabier Agirrezabala","orcid":"https://orcid.org/0000-0003-2610-1398","observed_orcids":["https://orcid.org/0000-0003-2610-1398"]},"institutions":[{"id":"https://openalex.org/I4210112728","display_name":"CIC bioGUNE","ror":"https://ror.org/02x5c5y60","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210112728"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Xabier Agirrezabala","raw_affiliation_strings":["Structural Biology Unit, CIC-bioGUNE, Bizkaia Technology Park, Derio, Spain","Structural Biology Unit, CIC-bioGUNE, Bizkaia Technology Park, Derio, 48160, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Unit, CIC-bioGUNE, Bizkaia Technology Park, Derio, Spain","institution_ids":["https://openalex.org/I4210112728"]},{"raw_affiliation_string":"Structural Biology Unit, CIC-bioGUNE, Bizkaia Technology Park, Derio, 48160, Spain","institution_ids":["https://openalex.org/I4210112728"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042892654","display_name":"Joachim Frank","orcid":"https://orcid.org/0000-0001-5449-6943","observed_orcids":["https://orcid.org/0000-0001-5449-6943","https://orcid.org/0000-0002-2442-1112"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joachim Frank","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY, 10027, USA","HHMI, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, P&S BB 2-221, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY, 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"HHMI, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, P&S BB 2-221, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014631856"],"corresponding_institution_ids":["https://openalex.org/I4210112728"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.1922,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.13076382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"4","first_page":"226","last_page":"226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translational-machinery","display_name":"translation machinery","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ribosome","display_name":"ribosome","score":0.9629999995231628},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ribosome-structure","display_name":"ribosome structure","score":0.5139999985694885},{"id":"https://openalex.org/keywords/conformational-dynamics","display_name":"conformational dynamics","score":0.7580000162124634},{"id":"https://openalex.org/keywords/bacterial-translation","display_name":"bacterial translation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.4449999928474426},{"id":"https://openalex.org/keywords/fluorescence-resonance-energy-transfer","display_name":"fluorescence resonance energy transfer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/kinetic-analysis","display_name":"kinetic analysis","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.746462345123291},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6097729206085205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5997081398963928},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.5926315784454346},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5700915455818176},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5229043364524841},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3307643532752991},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2164972722530365},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14112555980682373},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13764050602912903},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.12054300308227539},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1479-7364-4-4-226","doi":"https://doi.org/10.1186/1479-7364-4-4-226","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-7364-4-4-226","pdf_url":"https://humgenomics.biomedcentral.com/counter/pdf/10.1186/1479-7364-4-4-226","source":{"id":"https://openalex.org/S2738571386","display_name":"Human Genomics","issn_l":"1473-9542","issn":["1473-9542","1479-7364"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2976604","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2976604","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Genomics","raw_type":"Text"},{"id":"pmid:20511136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20511136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human genomics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0f1cf21aafa34503bdd936fb8c0cd0f2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0f1cf21aafa34503bdd936fb8c0cd0f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genomics, Vol 4, Iss 4, Pp 226-237 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1479-7364-4-4-226","doi":"https://doi.org/10.1186/1479-7364-4-4-226","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-7364-4-4-226","pdf_url":"https://humgenomics.biomedcentral.com/counter/pdf/10.1186/1479-7364-4-4-226","source":{"id":"https://openalex.org/S2738571386","display_name":"Human Genomics","issn_l":"1473-9542","issn":["1473-9542","1479-7364"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genomics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3048760434","display_name":"Structural Analysis of Macromolecular Assemblies","funder_award_id":"R01GM029169","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3331595142","display_name":null,"funder_award_id":"GM55440","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G4921166289","display_name":"Time-resolved Cryo-EM of Short-lived States in Eukaryotic Translation","funder_award_id":"R01GM055440","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5239950330","display_name":"STRUCTURAL ANALYSIS OF MACROMOLECULAR ASSEMBLY","funder_award_id":"R37GM029169","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000014357","display_name":null,"funder_award_id":"GM-29169","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000939390.pdf","grobid_xml":"https://content.openalex.org/works/W2000939390.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1677689941","https://openalex.org/W1967743590","https://openalex.org/W1969210187","https://openalex.org/W1977472875","https://openalex.org/W1978019627","https://openalex.org/W1978905228","https://openalex.org/W1979947584","https://openalex.org/W1986381105","https://openalex.org/W1987224264","https://openalex.org/W1987343866","https://openalex.org/W1995383156","https://openalex.org/W1998088239","https://openalex.org/W2004646850","https://openalex.org/W2008739199","https://openalex.org/W2009556295","https://openalex.org/W2010404690","https://openalex.org/W2014245123","https://openalex.org/W2017411951","https://openalex.org/W2018225684","https://openalex.org/W2024858227","https://openalex.org/W2027439585","https://openalex.org/W2031580496","https://openalex.org/W2034527511","https://openalex.org/W2035667407","https://openalex.org/W2045032671","https://openalex.org/W2048538166","https://openalex.org/W2048646541","https://openalex.org/W2054511300","https://openalex.org/W2058371301","https://openalex.org/W2064930185","https://openalex.org/W2068106209","https://openalex.org/W2072973641","https://openalex.org/W2073149987","https://openalex.org/W2075970359","https://openalex.org/W2077344571","https://openalex.org/W2078150939","https://openalex.org/W2080674156","https://openalex.org/W2080720176","https://openalex.org/W2081540493","https://openalex.org/W2082573799","https://openalex.org/W2082583578","https://openalex.org/W2084104969","https://openalex.org/W2086666821","https://openalex.org/W2088721967","https://openalex.org/W2089457247","https://openalex.org/W2092001691","https://openalex.org/W2095384140","https://openalex.org/W2108551329","https://openalex.org/W2110274742","https://openalex.org/W2113942795","https://openalex.org/W2114833790","https://openalex.org/W2117325595","https://openalex.org/W2117430673","https://openalex.org/W2126780661","https://openalex.org/W2126996947","https://openalex.org/W2131865971","https://openalex.org/W2133788397","https://openalex.org/W2136322092","https://openalex.org/W2137081760","https://openalex.org/W2137206793","https://openalex.org/W2142672816","https://openalex.org/W2145583354","https://openalex.org/W2146173293","https://openalex.org/W2152425069","https://openalex.org/W2154183572","https://openalex.org/W2162594896","https://openalex.org/W2163231470","https://openalex.org/W2163429634","https://openalex.org/W2169590497","https://openalex.org/W2221253507"],"related_works":["https://openalex.org/W7061476926","https://openalex.org/W4237008737","https://openalex.org/W2085226685","https://openalex.org/W2180353088","https://openalex.org/W144980351","https://openalex.org/W2419503478","https://openalex.org/W2026648136","https://openalex.org/W4396670623","https://openalex.org/W2110274742","https://openalex.org/W1534064270"],"abstract_inverted_index":{"Understanding":[0],"protein":[1,44,112],"synthesis":[2,113],"in":[3,35,43,54,74,114],"bacteria":[4],"and":[5,17,62,84],"humans":[6],"is":[7,47],"important":[8],"for":[9,20,100],"understanding":[10],"the":[11,23,26,36,39,56,80,91,96,104,107,115],"origin":[12],"of":[13,28,38,72,82,98,111],"many":[14],"human":[15],"diseases":[16],"devising":[18],"treatments":[19],"them.":[21],"Over":[22],"past":[24],"decade,":[25],"field":[27],"structural":[29],"biology":[30],"has":[31,93],"made":[32],"significant":[33],"advances":[34],"visualisation":[37],"molecular":[40],"machinery":[41],"involved":[42],"synthesis.":[45],"It":[46],"now":[48],"possible":[49],"to":[50,90],"discern,":[51],"at":[52],"least":[53],"outline,":[55],"way":[57],"that":[58],"interlocking":[59],"ribosomal":[60],"components":[61],"factors":[63],"adapt":[64],"their":[65],"conformations":[66],"throughout":[67],"this":[68],"process.":[69],"The":[70],"determination":[71],"structures":[73],"various":[75],"functional":[76],"contexts,":[77],"along":[78],"with":[79],"application":[81],"kinetic":[83],"fluorescent":[85],"resonance":[86],"energy":[87],"transfer":[88],"approaches":[89],"problem,":[92],"given":[94],"researchers":[95],"frame":[97],"reference":[99],"what":[101],"remains":[102],"as":[103],"greatest":[105],"challenge:":[106],"complete":[108],"dynamic":[109],"portrait":[110],"cell.":[116]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}