{"id":"https://openalex.org/W2000938193","doi":"https://doi.org/10.1016/1044-5323(95)90004-7","title":"The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains","display_name":"The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2000938193","doi":"https://doi.org/10.1016/1044-5323(95)90004-7","mag":"2000938193","pmid":"https://pubmed.ncbi.nlm.nih.gov/7612891"},"language":"en","primary_location":{"id":"doi:10.1016/1044-5323(95)90004-7","doi":"https://doi.org/10.1016/1044-5323(95)90004-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1044-5323(95)90004-7","pdf_url":null,"source":{"id":"https://openalex.org/S161731549","display_name":"Seminars in Immunology","issn_l":"1044-5323","issn":["1044-5323","1096-3618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008485301","display_name":"Heinrich Flaswinkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210164321","display_name":"Max Planck Institute of Immunobiology and Epigenetics","ror":"https://ror.org/058xzat49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinrich Flaswinkel","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Immunobiologie, Freiburg, Germany","Max-Planck-Institut fur Immunobiologie, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Immunobiologie, Freiburg, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]},{"raw_affiliation_string":"Max-Planck-Institut fur Immunobiologie, Freiburg, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043043042","display_name":"Marijke Barner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164321","display_name":"Max Planck Institute of Immunobiology and Epigenetics","ror":"https://ror.org/058xzat49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marijke Barner","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Immunbiologie, St\u00fcbeweg 51, Freiburg, D-79108, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Immunbiologie, St\u00fcbeweg 51, Freiburg, D-79108, Germany","institution_ids":["https://openalex.org/I4210164321"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013470603","display_name":"Michael G. Reth","orcid":"https://orcid.org/0000-0002-1025-7198","observed_orcids":["https://orcid.org/0000-0002-1025-7198"]},"institutions":[{"id":"https://openalex.org/I4210164321","display_name":"Max Planck Institute of Immunobiology and Epigenetics","ror":"https://ror.org/058xzat49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Reth","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Immunbiologie, St\u00fcbeweg 51, Freiburg, D-79108, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Immunbiologie, St\u00fcbeweg 51, Freiburg, D-79108, Germany","institution_ids":["https://openalex.org/I4210164321"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4370,"currency":"USD","value_usd":4370},"apc_paid":null,"fwci":0.6776,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.60671463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"21","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.2957000136375427,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itam","display_name":"ITAM","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antigen-receptor-signaling","display_name":"antigen receptor signaling","score":0.75},{"id":"https://openalex.org/keywords/fc-receptor-signaling","display_name":"Fc receptor signaling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B cell receptor","score":0.7929999828338623},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9440000057220459},{"id":"https://openalex.org/keywords/receptor-cross-linking","display_name":"receptor cross-linking","score":0.8849999904632568},{"id":"https://openalex.org/keywords/sh2-domain-binding","display_name":"SH2 domain binding","score":0.4169999957084656},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.8362736105918884},{"id":"https://openalex.org/C29907709","wikidata":"https://www.wikidata.org/wiki/Q6005558","display_name":"Immunoreceptor tyrosine-based activation motif","level":5,"score":0.7667657136917114},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7021763920783997},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6769434213638306},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6470260620117188},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5770890116691589},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5643610954284668},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.55544513463974},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5237493515014648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5101309418678284},{"id":"https://openalex.org/C183141693","wikidata":"https://www.wikidata.org/wiki/Q5005962","display_name":"Tyrosine-protein kinase CSK","level":5,"score":0.4911634624004364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4854150712490082},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4373515248298645},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.42881259322166443},{"id":"https://openalex.org/C2911166042","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor Protein-Tyrosine Kinases","level":4,"score":0.42631995677948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3280823528766632}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015688","descriptor_name":"Oncogene Protein pp60(v-src)","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015688","descriptor_name":"Oncogene Protein pp60(v-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051925","descriptor_name":"CD79 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/1044-5323(95)90004-7","doi":"https://doi.org/10.1016/1044-5323(95)90004-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1044-5323(95)90004-7","pdf_url":null,"source":{"id":"https://openalex.org/S161731549","display_name":"Seminars in Immunology","issn_l":"1044-5323","issn":["1044-5323","1096-3618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunology","raw_type":"journal-article"},{"id":"pmid:7612891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7612891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:freidok.uni-freiburg.de:17856","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/17856","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Seminars in Immunology. - 7, 1 (1995) , 21-27, ISSN: 1044-5323","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W78775163","https://openalex.org/W136542906","https://openalex.org/W1481629090","https://openalex.org/W1595867504","https://openalex.org/W1817318311","https://openalex.org/W1855385293","https://openalex.org/W1860326926","https://openalex.org/W1965518221","https://openalex.org/W1975638311","https://openalex.org/W1980004909","https://openalex.org/W1983960385","https://openalex.org/W1985644499","https://openalex.org/W1986758681","https://openalex.org/W1999824494","https://openalex.org/W2002126985","https://openalex.org/W2003044215","https://openalex.org/W2004458954","https://openalex.org/W2012694659","https://openalex.org/W2012879673","https://openalex.org/W2014154395","https://openalex.org/W2036524475","https://openalex.org/W2040909391","https://openalex.org/W2042209841","https://openalex.org/W2044725781","https://openalex.org/W2047265140","https://openalex.org/W2052561585","https://openalex.org/W2058885870","https://openalex.org/W2063495909","https://openalex.org/W2075955998","https://openalex.org/W2077236851","https://openalex.org/W2077941881","https://openalex.org/W2086151489","https://openalex.org/W2091956869","https://openalex.org/W2139966252","https://openalex.org/W2146008129","https://openalex.org/W2146573379","https://openalex.org/W2151858512","https://openalex.org/W2164682544","https://openalex.org/W2166141440","https://openalex.org/W2398285276","https://openalex.org/W6645296196","https://openalex.org/W6669359531","https://openalex.org/W6669906836"],"related_works":["https://openalex.org/W1586171131","https://openalex.org/W1928679615","https://openalex.org/W2945181102","https://openalex.org/W2022338314","https://openalex.org/W2062131041","https://openalex.org/W4247400052","https://openalex.org/W2017298009","https://openalex.org/W2084333005","https://openalex.org/W1996058409","https://openalex.org/W2079869215"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
