{"id":"https://openalex.org/W2000933385","doi":"https://doi.org/10.1016/j.bbrc.2009.08.047","title":"Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery","display_name":"Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery","publication_year":2009,"publication_date":"2009-08-13","ids":{"openalex":"https://openalex.org/W2000933385","doi":"https://doi.org/10.1016/j.bbrc.2009.08.047","mag":"2000933385","pmid":"https://pubmed.ncbi.nlm.nih.gov/19682429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748326"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2009.08.047","doi":"https://doi.org/10.1016/j.bbrc.2009.08.047","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2009.08.047","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748326","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110461007","display_name":"Lixin Mi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lixin Mi","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA. lm293@georgetown.edu","Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA. lm293@georgetown.edu","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010610241","display_name":"Nanqin Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nanqin Gan","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016623102","display_name":"Fung\u2010Lung Chung","orcid":"https://orcid.org/0000-0001-8028-6448","observed_orcids":["https://orcid.org/0000-0001-8028-6448"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fung-Lung Chung","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110461007"],"corresponding_institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.2212,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.75788865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"388","issue":"2","first_page":"456","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.11829999834299088,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isothiocyanates","display_name":"isothiocyanates","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/misfolded-protein-clearance","display_name":"misfolded protein clearance","score":0.7200000286102295},{"id":"https://openalex.org/keywords/alpha-tubulin","display_name":"alpha-tubulin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/beta-tubulin","display_name":"beta-tubulin","score":1.0},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9020000100135803},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/autophagy-lysosome-pathway","display_name":"autophagy-lysosome pathway","score":0.7749999761581421},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.550000011920929},{"id":"https://openalex.org/keywords/dynein","display_name":"dynein","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C187436293","wikidata":"https://www.wikidata.org/wiki/Q4692265","display_name":"Aggresome","level":4,"score":0.9961073398590088},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.7866306304931641},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7442834973335266},{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.7013088464736938},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6771726012229919},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6506528258323669},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4928407669067383},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4843955636024475},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.4260212182998657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40935570001602173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34728461503982544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013454","descriptor_name":"Sulfoxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013861","descriptor_name":"Thiocyanates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017879","descriptor_name":"Isothiocyanates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbrc.2009.08.047","doi":"https://doi.org/10.1016/j.bbrc.2009.08.047","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2009.08.047","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:19682429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19682429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2748326","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748326","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Biophys Res Commun","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2748326","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748326","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Biophys Res Commun","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6189174033","display_name":"Mechanisms of Chemoprevention by Isothiocyanates","funder_award_id":"R01CA100853","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310137","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03"},{"id":"https://openalex.org/F4320310223","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60"},{"id":"https://openalex.org/F4320312852","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67"},{"id":"https://openalex.org/F4320332500","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1969342645","https://openalex.org/W1985219828","https://openalex.org/W1988146888","https://openalex.org/W1997369314","https://openalex.org/W2009125409","https://openalex.org/W2021242983","https://openalex.org/W2043223461","https://openalex.org/W2044085158","https://openalex.org/W2068213179","https://openalex.org/W2080582085","https://openalex.org/W2090926709","https://openalex.org/W2097269034","https://openalex.org/W2139058438","https://openalex.org/W2149761960","https://openalex.org/W2170290617"],"related_works":["https://openalex.org/W2352628556","https://openalex.org/W2149761960","https://openalex.org/W2137996940","https://openalex.org/W183951951","https://openalex.org/W2027883616","https://openalex.org/W7097577622","https://openalex.org/W2009125409","https://openalex.org/W2076120507","https://openalex.org/W2111837223","https://openalex.org/W2045189117"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}