{"id":"https://openalex.org/W2000930869","doi":"https://doi.org/10.1002/jor.20177","title":"Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells","display_name":"Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells","publication_year":2006,"publication_date":"2006-05-16","ids":{"openalex":"https://openalex.org/W2000930869","doi":"https://doi.org/10.1002/jor.20177","mag":"2000930869","pmid":"https://pubmed.ncbi.nlm.nih.gov/16705696"},"language":"en","primary_location":{"id":"doi:10.1002/jor.20177","doi":"https://doi.org/10.1002/jor.20177","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.20177","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20177","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20177","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112701053","display_name":"Tadahiko Kubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tadahiko Kubo","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Hiroshima 734-8551, Japan. kubot@hiroshima-u.ac.jp","Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Hiroshima 734-8551, Japan. kubot@hiroshima-u.ac.jp","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013770696","display_name":"Shoji Shimose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoji Shimose","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104111220","display_name":"Toshihiro Matsuo","orcid":"https://orcid.org/0000-0002-1018-1031","observed_orcids":["https://orcid.org/0000-0002-1018-1031"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Matsuo","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111709157","display_name":"Kumi Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumi Tanaka","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078990480","display_name":"Yuji Yasunaga","orcid":"https://orcid.org/0000-0002-1086-537X","observed_orcids":["https://orcid.org/0000-0002-1086-537X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Yasunaga","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026762883","display_name":"Akira Sakai","orcid":"https://orcid.org/0000-0003-0128-8395","observed_orcids":["https://orcid.org/0000-0003-0128-8395"]},"institutions":[{"id":"https://openalex.org/I4405287266","display_name":"Research Institute for Radiation Biology and Medicine, Hiroshima University","ror":"https://ror.org/04mfv5z87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Sakai","raw_affiliation_strings":["Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I4405287266"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029011338","display_name":"Mitsuo Ochi","orcid":"https://orcid.org/0000-0002-7363-873X","observed_orcids":["https://orcid.org/0000-0002-7363-873X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuo Ochi","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112701053"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":2.4265,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.8806771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"6","first_page":"1138","last_page":"1144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minodronate","display_name":"minodronate","score":1.0},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9789999723434448},{"id":"https://openalex.org/keywords/malignant-bone-tumors","display_name":"malignant bone tumors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anti-invasive-effect","display_name":"anti-invasive effect","score":0.5979999899864197},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.781000018119812},{"id":"https://openalex.org/keywords/incadronate","display_name":"incadronate","score":0.8130000233650208},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8700993657112122},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.7926990985870361},{"id":"https://openalex.org/C2776302905","wikidata":"https://www.wikidata.org/wiki/Q1076087","display_name":"Chondrosarcoma","level":2,"score":0.7607596516609192},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7097762823104858},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6647900342941284},{"id":"https://openalex.org/C2909636867","wikidata":"https://www.wikidata.org/wiki/Q56014469","display_name":"Bone Sarcoma","level":3,"score":0.6529711484909058},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.5664376020431519},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5496028661727905},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5218271613121033},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4910433292388916},{"id":"https://openalex.org/C2776035513","wikidata":"https://www.wikidata.org/wiki/Q1328805","display_name":"Bone cancer","level":3,"score":0.48302778601646423},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46905258297920227},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.44959557056427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4472804069519043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40240564942359924},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39455515146255493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24709373712539673},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.138909250497818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.055884331464767456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/jor.20177","doi":"https://doi.org/10.1002/jor.20177","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.20177","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20177","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:16705696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16705696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01372:0006661042","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2007455","pdf_url":"https://hiroshima.repo.nii.ac.jp/record/2007455/files/JOR_24_1138.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal article"},{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02007455","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2007455","pdf_url":null,"source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:ir.lib.hiroshima-u.ac.jp:00021551","doi":null,"is_oa":false,"landing_page_url":"http://ir.lib.hiroshima-u.ac.jp/00021551","pdf_url":null,"source":{"id":"https://openalex.org/S4377196292","display_name":"Hiroshima University Acedemic Information Repository (Hiroshima University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I113306721","host_organization_name":"Hiroshima University","host_organization_lineage":["https://openalex.org/I113306721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1002/jor.20177","doi":"https://doi.org/10.1002/jor.20177","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.20177","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20177","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000930869.pdf","grobid_xml":"https://content.openalex.org/works/W2000930869.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W99959787","https://openalex.org/W322718260","https://openalex.org/W1521095066","https://openalex.org/W1563468257","https://openalex.org/W1938796902","https://openalex.org/W1965795988","https://openalex.org/W1974831848","https://openalex.org/W1980810506","https://openalex.org/W1984599836","https://openalex.org/W1994414479","https://openalex.org/W2001897537","https://openalex.org/W2014850113","https://openalex.org/W2017654113","https://openalex.org/W2023851252","https://openalex.org/W2034141221","https://openalex.org/W2038995854","https://openalex.org/W2052911925","https://openalex.org/W2053802095","https://openalex.org/W2064279648","https://openalex.org/W2069351982","https://openalex.org/W2076769374","https://openalex.org/W2148077417","https://openalex.org/W2161061591","https://openalex.org/W4236297959"],"related_works":["https://openalex.org/W1985577468","https://openalex.org/W4236297959","https://openalex.org/W2415657570","https://openalex.org/W2188611138","https://openalex.org/W2130711666","https://openalex.org/W1938796902","https://openalex.org/W2038995854","https://openalex.org/W2010853879","https://openalex.org/W7097865557","https://openalex.org/W2024507601"],"abstract_inverted_index":{"Little":[0],"is":[1],"known":[2],"about":[3],"the":[4,22,40,50,76,85,97,128,193,219],"biological":[5],"effects":[6,24,41,78,86],"of":[7,16,25,33,42,56,79,87,99,111,122,130,179,187,190,195,204,221],"bisphosphonates":[8,126,142],"on":[9,30,49,81,89],"primary":[10],"malignant":[11,35,224],"bone":[12,36,132,225],"tumors.":[13,37,226],"The":[14],"purpose":[15],"this":[17],"study":[18],"was":[19],"to":[20,113,162],"investigate":[21],"antitumor":[23],"newly":[26],"developed":[27],"minodronate":[28],"(MIN)":[29],"a":[31,105,176,214],"variety":[32],"human":[34],"We":[38],"examined":[39],"MIN":[43,80,88,95,170,191,211],"and":[44,53,65,84,152,156,167],"clinically":[45],"relevant":[46],"incadronate":[47],"(INC)":[48],"proliferation,":[51],"apoptosis,":[52],"cell":[54,71,102,144],"cycle":[55,145],"two":[57,61,66],"osteosarcoma":[58],"(Saos-2,":[59],"MG-63),":[60],"chondrosarcoma":[62],"(SW1353,":[63],"OUMS27),":[64],"Ewing's":[67],"sarcoma":[68,82,139,149,198],"(RD-ES,":[69],"SK-ES-1)":[70],"lines.":[72],"Furthermore,":[73],"we":[74],"investigated":[75],"anti-invasion":[77],"cells":[83,135,150],"tumor":[90],"growth":[91,194],"in":[92,104,147,154,165,199,218],"nude":[93,200],"mice.":[94],"inhibited":[96,192],"viability":[98,129],"all":[100,148],"six":[101],"lines":[103],"dose-dependent":[106],"manner":[107],"with":[108,223],"IC50":[109],"values":[110],"2.7":[112],"5.0":[114],"microM,":[115],"which":[116],"were":[117],"significantly":[118,171],"lower":[119],"than":[120,138],"those":[121],"INC.":[123],"Importantly,":[124],"both":[125],"affected":[127],"normal":[131],"marrow":[133],"stromal":[134],"much":[136],"less":[137],"cells.":[140,169],"Both":[141],"induced":[143],"perturbation":[146],"tested":[151],"apoptosis":[153,164],"Saos-2":[155],"SW1353":[157],"cells,":[158],"although":[159],"they":[160],"failed":[161],"induce":[163],"RD-ES":[166],"SK-ES-1":[168,196],"suppressed":[172],"invasion,":[173],"even":[174],"at":[175],"low":[177],"concentration":[178],"1":[180],"microM":[181],"(p":[182],"<":[183],"0.01).":[184],"Daily":[185],"injection":[186],"5":[188],"microg":[189],"xenograft":[197],"mice":[201],"without":[202],"loss":[203],"body":[205],"weight.":[206],"These":[207],"findings":[208],"suggest":[209],"that":[210],"may":[212],"have":[213],"beneficial":[215],"adjuvant":[216],"role":[217],"treatment":[220],"patients":[222]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}