{"id":"https://openalex.org/W2000928261","doi":"https://doi.org/10.1371/journal.ppat.1000137","title":"A C-Terminal Protease-Resistant Prion Fragment Distinguishes Ovine \u201cCH1641-Like\u201d Scrapie from Bovine Classical and L-Type BSE in Ovine Transgenic Mice","display_name":"A C-Terminal Protease-Resistant Prion Fragment Distinguishes Ovine \u201cCH1641-Like\u201d Scrapie from Bovine Classical and L-Type BSE in Ovine Transgenic Mice","publication_year":2008,"publication_date":"2008-08-28","ids":{"openalex":"https://openalex.org/W2000928261","doi":"https://doi.org/10.1371/journal.ppat.1000137","mag":"2000928261","pmid":"https://pubmed.ncbi.nlm.nih.gov/18769714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2516186"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1000137","doi":"https://doi.org/10.1371/journal.ppat.1000137","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000137","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000137&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000137&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085304984","display_name":"Thierry Baron","orcid":"https://orcid.org/0000-0001-5396-7707","observed_orcids":["https://orcid.org/0000-0001-5396-7707"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thierry Baron","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments-Lyon, Unit\u00e9 ATNC, Lyon, France. t.baron@lyon.afssa.fr","Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments-Lyon, Unit\u00e9 ATNC, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments-Lyon, Unit\u00e9 ATNC, Lyon, France. t.baron@lyon.afssa.fr","institution_ids":[]},{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments-Lyon, Unit\u00e9 ATNC, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040468965","display_name":"Anna A. Bencsik","orcid":"https://orcid.org/0000-0002-8671-6290","observed_orcids":["https://orcid.org/0000-0002-8671-6290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Bencsik","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061302555","display_name":"Johann Vulin","orcid":"https://orcid.org/0000-0003-3680-0088","observed_orcids":["https://orcid.org/0000-0003-3680-0088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann Vulin","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086970240","display_name":"Anne-Ga\u00eblle Biacab\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne-Ga\u00eblle Biacabe","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108597209","display_name":"Eric Morignat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Morignat","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069031997","display_name":"J\u00e9r\u00e9my Verch\u00e8re","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00e9my Verchere","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068417837","display_name":"Dominique B\u00e9temps","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dominique Betemps","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments\u2013Lyon, Unit\u00e9 ATNC, Lyon, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085304984"],"corresponding_institution_ids":[],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.128,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.87023431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"4","issue":"8","first_page":"e1000137","last_page":"e1000137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scrapie","display_name":"scrapie","score":0.6869999766349792},{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/protease-resistant-prion-protein","display_name":"protease-resistant prion protein","score":0.9629999995231628},{"id":"https://openalex.org/keywords/c-terminal-cleavage","display_name":"C-terminal cleavage","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glycoforms","display_name":"glycoforms","score":0.597000002861023},{"id":"https://openalex.org/keywords/prion-transmission","display_name":"prion transmission","score":0.5230000019073486},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.30799999833106995},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.8604660034179688},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6553784608840942},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.6485695838928223},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6470595598220825},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6139049530029297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.572652280330658},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.46409550309181213},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4371764659881592},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2124781608581543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14789986610412598},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11765867471694946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.059451162815093994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.044933706521987915},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.ppat.1000137","doi":"https://doi.org/10.1371/journal.ppat.1000137","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000137","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000137&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmid:18769714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18769714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2516186","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2516186/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.1972","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.1972","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0f/6f/PLoS_Pathog_2008_Aug_29_4(8)_e1000137.tar.gz","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00318222v1","doi":null,"is_oa":true,"landing_page_url":"https://anses.hal.science/hal-00318222","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 2008, 4 (8), pp.e1000137. &#x27E8;10.1371/journal.ppat.1000137&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9f2b0d741e6246e28b46f739aa756aaf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9f2b0d741e6246e28b46f739aa756aaf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 4, Iss 8, p e1000137 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/149657","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_C_Terminal_Protease_Resistant_Prion_Fragment_Distinguishes_Ovine_CH1641_Like_Scrapie_from_Bovine_Classical_and_L_Type_BSE_in_Ovine_Transgenic_Mice/149657","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1000137","doi":"https://doi.org/10.1371/journal.ppat.1000137","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000137","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000137&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000928261.pdf","grobid_xml":"https://content.openalex.org/works/W2000928261.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W310556292","https://openalex.org/W1607679682","https://openalex.org/W1624018543","https://openalex.org/W1981387468","https://openalex.org/W1991237179","https://openalex.org/W1991644458","https://openalex.org/W1995580711","https://openalex.org/W1998228132","https://openalex.org/W2005555107","https://openalex.org/W2006427685","https://openalex.org/W2013575731","https://openalex.org/W2016565903","https://openalex.org/W2017092523","https://openalex.org/W2027028319","https://openalex.org/W2028388344","https://openalex.org/W2034673903","https://openalex.org/W2041644198","https://openalex.org/W2049719457","https://openalex.org/W2052107975","https://openalex.org/W2055288092","https://openalex.org/W2064722614","https://openalex.org/W2066113001","https://openalex.org/W2068826304","https://openalex.org/W2070015763","https://openalex.org/W2072077683","https://openalex.org/W2076328804","https://openalex.org/W2077455131","https://openalex.org/W2096744322","https://openalex.org/W2098021716","https://openalex.org/W2119861236","https://openalex.org/W2126655133","https://openalex.org/W2130432938","https://openalex.org/W2134138339","https://openalex.org/W2134393699","https://openalex.org/W2137462514","https://openalex.org/W2140416160","https://openalex.org/W2142073103","https://openalex.org/W2142880647","https://openalex.org/W2143358380","https://openalex.org/W2145420465","https://openalex.org/W2154861340","https://openalex.org/W2158138061","https://openalex.org/W2161199496","https://openalex.org/W2167884034","https://openalex.org/W2169074095","https://openalex.org/W2324660492","https://openalex.org/W4251167651"],"related_works":["https://openalex.org/W2066113001","https://openalex.org/W2077455131","https://openalex.org/W2335216892","https://openalex.org/W2069548140","https://openalex.org/W2320713307","https://openalex.org/W7100652181","https://openalex.org/W2011089631","https://openalex.org/W2021399080","https://openalex.org/W2032952473","https://openalex.org/W2902793448"],"abstract_inverted_index":{"The":[0],"protease-resistant":[1],"prion":[2,234],"protein":[3],"(PrP(res))":[4],"of":[5,15,39,43,56,72,116,155,171,211,233],"a":[6,22,149],"few":[7],"natural":[8,24,77,213],"scrapie":[9,25,78,186,201,214,242],"isolates":[10,79,92,129,215],"identified":[11,197],"in":[12,45,74,82,105,162,164,192,198,204,209,248],"sheep,":[13],"reminiscent":[14],"the":[16,69,117,127,169,199,230],"experimental":[17,185],"isolate":[18],"CH1641":[19],"derived":[20],"from":[21,131,183],"British":[23],"case,":[26],"showed":[27],"partial":[28],"molecular":[29,70,114,218,231],"similarities":[30],"to":[31,62,88,96,123,220],"ovine":[32,84,241,250],"bovine":[33,244],"spongiform":[34],"encephalopathy":[35],"(BSE).":[36],"Recent":[37],"discovery":[38],"an":[40,83,138,226,249],"atypical":[41],"form":[42,55,120],"BSE":[44,48,57,136,246],"cattle,":[46],"L-type":[47,97,124,133,245],"or":[49],"BASE,":[50],"suggests":[51],"that":[52],"also":[53],"this":[54],"might":[58,93],"have":[59],"been":[60],"transmitted":[61,247],"sheep.":[63],"We":[64,99],"studied":[65],"by":[66,137,148],"Western":[67],"blot":[68],"features":[71,219],"PrP(res)":[73,103,119,142,156,159,165,175,177,222],"four":[75],"\"CH1641-like\"":[76,91,128,240],"after":[80],"transmission":[81],"transgenic":[85,251],"model":[86],"(TgOvPrP4),":[87],"see":[89],"if":[90],"be":[94,181],"linked":[95],"BSE.":[98,125],"found":[100],"less":[101],"diglycosylated":[102,174],"than":[104],"classical":[106,135],"BSE,":[107],"but":[108,195],"similar":[109],"glycoform":[110],"proportions":[111],"and":[112,134,158,167,173,206,236,243],"apparent":[113],"masses":[115],"usual":[118],"(PrP(res)":[121,144],"#1)":[122],"However,":[126],"differed":[130],"both":[132],"abundant,":[139],"C-terminally":[140],"cleaved":[141],"product":[143],"#2)":[145],"specifically":[146],"recognised":[147],"C-terminal":[150],"antibody":[151],"(SAF84).":[152],"Differential":[153],"immunoprecipitation":[154],"#1":[157],"#2":[160,178,223],"resulted":[161],"enrichment":[163],"#2,":[166],"demonstrated":[168],"presence":[170],"mono-":[172],"products.":[176],"could":[179],"not":[180],"obtained":[182],"several":[184],"sources":[187],"(SSBP1,":[188],"79A,":[189],"Chandler,":[190],"C506M3)":[191],"TgOvPrP4":[193],"mice,":[194],"was":[196],"87V":[200],"strain":[202],"and,":[203],"lower":[205],"variable":[207],"proportions,":[208],"5":[210,212],"with":[216],"different":[217],"CH1641.":[221],"identification":[224],"provides":[225],"additional":[227],"method":[228],"for":[229],"discrimination":[232],"strains,":[235],"demonstrates":[237],"differences":[238],"between":[239],"mouse":[252],"model.":[253]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
