{"id":"https://openalex.org/W2000920295","doi":"https://doi.org/10.4161/biom.24490","title":"Enhancing retention and efficacy of cardiosphere-derived cells administered after myocardial infarction using a hyaluronan-gelatin hydrogel","display_name":"Enhancing retention and efficacy of cardiosphere-derived cells administered after myocardial infarction using a hyaluronan-gelatin hydrogel","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2000920295","doi":"https://doi.org/10.4161/biom.24490","mag":"2000920295","pmid":"https://pubmed.ncbi.nlm.nih.gov/23538511","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732325"},"language":"en","primary_location":{"id":"doi:10.4161/biom.24490","doi":"https://doi.org/10.4161/biom.24490","is_oa":true,"landing_page_url":"https://doi.org/10.4161/biom.24490","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/biom.24490?needAccess=true","source":{"id":"https://openalex.org/S4210174368","display_name":"Biomatter","issn_l":"2159-2527","issn":["2159-2527","2159-2535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomatter","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/biom.24490?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088118286","display_name":"Rachel Ruckdeschel Smith","orcid":"https://orcid.org/0000-0002-9784-3586","observed_orcids":["https://orcid.org/0000-0002-9784-3586"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachel Ruckdeschel Smith","raw_affiliation_strings":["Capricor Inc.; 8700 Beverly Boulevard; Los Angeles, CA USA","8700 Beverly Boulevard","Capricor Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capricor Inc.; 8700 Beverly Boulevard; Los Angeles, CA USA","institution_ids":[]},{"raw_affiliation_string":"8700 Beverly Boulevard","institution_ids":[]},{"raw_affiliation_string":"Capricor Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046381230","display_name":"Eduardo Marb\u00e1n","orcid":"https://orcid.org/0000-0002-3863-280X","observed_orcids":["https://orcid.org/0000-0002-3863-280X"]},"institutions":[{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Marb\u00e1n","raw_affiliation_strings":["Cedars-Sinai Heart Institute; Los Angeles, CA USA","Los Angeles, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Heart Institute; Los Angeles, CA USA","institution_ids":["https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Los Angeles, CA USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069866872","display_name":"Linda Marb\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda Marb\u00e1n","raw_affiliation_strings":["Capricor Inc.; 8700 Beverly Boulevard; Los Angeles, CA USA","8700 Beverly Boulevard","Capricor Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capricor Inc.; 8700 Beverly Boulevard; Los Angeles, CA USA","institution_ids":[]},{"raw_affiliation_string":"8700 Beverly Boulevard","institution_ids":[]},{"raw_affiliation_string":"Capricor Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088118286"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9556,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.64021164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.33959999680519104,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiosphere-derived-cells","display_name":"cardiosphere-derived cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.921999990940094},{"id":"https://openalex.org/keywords/cell-delivery","display_name":"cell delivery","score":0.7160000205039978},{"id":"https://openalex.org/keywords/intramyocardial-injection","display_name":"intramyocardial injection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cell-retention","display_name":"cell retention","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-therapy-efficacy","display_name":"cell therapy efficacy","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7968432903289795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6950235962867737},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.6814440488815308},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6247268915176392},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5698273777961731},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45849525928497314},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.4493666887283325},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.43974053859710693},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.43809089064598083},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41869670152664185},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3688662648200989},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3130728602409363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13560715317726135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07070523500442505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0683165192604065},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.05452919006347656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020136","descriptor_name":"Hydrogel, Polyethylene Glycol Dimethacrylate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020136","descriptor_name":"Hydrogel, Polyethylene Glycol Dimethacrylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/biom.24490","doi":"https://doi.org/10.4161/biom.24490","is_oa":true,"landing_page_url":"https://doi.org/10.4161/biom.24490","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/biom.24490?needAccess=true","source":{"id":"https://openalex.org/S4210174368","display_name":"Biomatter","issn_l":"2159-2527","issn":["2159-2527","2159-2535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomatter","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2726416","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3732325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomatter","raw_type":"Text"},{"id":"pmid:23538511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23538511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomatter","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/biom.24490","doi":"https://doi.org/10.4161/biom.24490","is_oa":true,"landing_page_url":"https://doi.org/10.4161/biom.24490","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/biom.24490?needAccess=true","source":{"id":"https://openalex.org/S4210174368","display_name":"Biomatter","issn_l":"2159-2527","issn":["2159-2527","2159-2535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomatter","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000920295.pdf","grobid_xml":"https://content.openalex.org/works/W2000920295.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1980917009","https://openalex.org/W1987786332","https://openalex.org/W2000951446","https://openalex.org/W2012154384","https://openalex.org/W2024812933","https://openalex.org/W2043456930","https://openalex.org/W2044461758","https://openalex.org/W2045699395","https://openalex.org/W2051968888","https://openalex.org/W2069740040","https://openalex.org/W2071881591","https://openalex.org/W2080539468","https://openalex.org/W2092756213","https://openalex.org/W2097105593","https://openalex.org/W2111485551","https://openalex.org/W2111486034","https://openalex.org/W2112792041","https://openalex.org/W2120261681","https://openalex.org/W2130308734","https://openalex.org/W2130918540","https://openalex.org/W2143298795","https://openalex.org/W2144327104","https://openalex.org/W2147615829","https://openalex.org/W2147906362","https://openalex.org/W2161404635","https://openalex.org/W2164159264","https://openalex.org/W2167666858","https://openalex.org/W2224057980","https://openalex.org/W2526990955","https://openalex.org/W2547041647","https://openalex.org/W2623604297","https://openalex.org/W4211191293"],"related_works":["https://openalex.org/W2071881591","https://openalex.org/W4395041579","https://openalex.org/W4413469661","https://openalex.org/W2016680045","https://openalex.org/W3134970277","https://openalex.org/W7043608948","https://openalex.org/W187611444","https://openalex.org/W3094560250","https://openalex.org/W2011544428","https://openalex.org/W3006261740"],"abstract_inverted_index":{"Cardiosphere-derived":[0],"cells":[1],"(CDCs)":[2],"are":[3,8,25],"under":[4],"clinical":[5,14,40],"development":[6],"and":[7,34,63,85],"currently":[9],"being":[10],"tested":[11],"in":[12,38,56,67,71],"a":[13,21,57,76],"trial":[15],"enrolling":[16],"patients":[17],"who":[18],"have":[19,35],"undergone":[20],"myocardial":[22,47,61],"infarction.":[23],"CDCs":[24,55,84],"presently":[26],"administered":[27],"via":[28,60],"infusion":[29],"into":[30],"the":[31,52,64,81],"infarct-related":[32],"artery":[33],"been":[36],"shown":[37],"early":[39],"trials":[41],"to":[42],"be":[43],"effective":[44],"agents":[45],"of":[46,54,75,83],"regeneration.":[48],"This":[49],"review":[50],"describes":[51],"administration":[53],"hyaluronan-gelatin":[58],"hydrogel":[59,86],"injection":[62],"subsequent":[65],"improvements":[66],"therapeutic":[68],"benefit":[69],"seen":[70],"animal":[72],"models.":[73],"Development":[74],"next":[77],"generation":[78],"therapy":[79],"involving":[80],"combination":[82],"is":[87],"discussed.":[88]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}