{"id":"https://openalex.org/W2000907068","doi":"https://doi.org/10.1089/ten.tea.2009.0064","title":"The Human Umbilical Vein with Wharton's Jelly as an Allogeneic, Acellular Construct for Vocal Fold Restoration","display_name":"The Human Umbilical Vein with Wharton's Jelly as an Allogeneic, Acellular Construct for Vocal Fold Restoration","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W2000907068","doi":"https://doi.org/10.1089/ten.tea.2009.0064","mag":"2000907068","pmid":"https://pubmed.ncbi.nlm.nih.gov/19456236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792072"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tea.2009.0064","doi":"https://doi.org/10.1089/ten.tea.2009.0064","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2009.0064","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792072","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067531377","display_name":"Roger W. Chan","orcid":"https://orcid.org/0000-0002-7135-9702","observed_orcids":["https://orcid.org/0000-0002-7135-9702"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roger W. Chan","raw_affiliation_strings":["Otolaryngology \u2013 Head and Neck Surgery, Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, Texas","Otolaryngology - Head and Neck Surgery, Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9035, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology \u2013 Head and Neck Surgery, Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Otolaryngology - Head and Neck Surgery, Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9035, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026872168","display_name":"Maritza L. Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maritza L. Rodriguez","raw_affiliation_strings":["Mammalian Cell and Organ Culture Laboratory, School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mammalian Cell and Organ Culture Laboratory, School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, Oklahoma","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036952194","display_name":"Peter S. McFetridge","orcid":"https://orcid.org/0000-0002-3177-8750","observed_orcids":["https://orcid.org/0000-0002-3177-8750"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter S. McFetridge","raw_affiliation_strings":["Mammalian Cell and Organ Culture Laboratory, School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mammalian Cell and Organ Culture Laboratory, School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, Oklahoma","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067531377"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":2.6988,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8912592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"11","first_page":"3537","last_page":"3546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-umbilical-vein","display_name":"human umbilical vein","score":0.8999999761581421},{"id":"https://openalex.org/keywords/wharton-s-jelly","display_name":"Wharton's jelly","score":0.9980000257492065},{"id":"https://openalex.org/keywords/decellularization","display_name":"decellularization","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vocal-fold-lamina-propria","display_name":"vocal fold lamina propria","score":0.9039999842643738},{"id":"https://openalex.org/keywords/vocal-fold-fibroblasts","display_name":"vocal fold fibroblasts","score":0.8130000233650208},{"id":"https://openalex.org/keywords/recellularization","display_name":"recellularization","score":0.8960000276565552},{"id":"https://openalex.org/keywords/collagen-density","display_name":"collagen density","score":0.7070000171661377},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/vocal-fold-reconstruction","display_name":"vocal fold reconstruction","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.9392858147621155},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6397226452827454},{"id":"https://openalex.org/C2780336059","wikidata":"https://www.wikidata.org/wiki/Q215558","display_name":"Vocal folds","level":3,"score":0.543830394744873},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.5216710567474365},{"id":"https://openalex.org/C119577978","wikidata":"https://www.wikidata.org/wiki/Q913900","display_name":"Wharton's jelly","level":3,"score":0.5020623207092285},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.49032142758369446},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4758826792240143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4678676128387451},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.46595603227615356},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.452243447303772},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.4396054446697235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.405534952878952},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27429917454719543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2682676911354065},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18563169240951538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1650182008743286},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.140834242105484},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.11362156271934509},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.08270061016082764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011474","descriptor_name":"Prosthesis Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014470","descriptor_name":"Umbilical Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1089/ten.tea.2009.0064","doi":"https://doi.org/10.1089/ten.tea.2009.0064","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2009.0064","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2792072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792072","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},{"id":"pmid:19456236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19456236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part A","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2792072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792072","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1694862109","display_name":"Biomechanical characterization of vocal fold tissues","funder_award_id":"R01DC006101","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W163783442","https://openalex.org/W1965074521","https://openalex.org/W1967943666","https://openalex.org/W1973751600","https://openalex.org/W1975971512","https://openalex.org/W1977516243","https://openalex.org/W1981688121","https://openalex.org/W1985280243","https://openalex.org/W1986151676","https://openalex.org/W1989772717","https://openalex.org/W1995421863","https://openalex.org/W2002230244","https://openalex.org/W2010570292","https://openalex.org/W2011193962","https://openalex.org/W2015525113","https://openalex.org/W2016438499","https://openalex.org/W2026356665","https://openalex.org/W2031845997","https://openalex.org/W2036075940","https://openalex.org/W2042112073","https://openalex.org/W2048445501","https://openalex.org/W2050825851","https://openalex.org/W2056675118","https://openalex.org/W2068409500","https://openalex.org/W2072467743","https://openalex.org/W2074519869","https://openalex.org/W2076933480","https://openalex.org/W2077644606","https://openalex.org/W2081084534","https://openalex.org/W2088218800","https://openalex.org/W2090424277","https://openalex.org/W2104933191","https://openalex.org/W2118877693","https://openalex.org/W2126313677","https://openalex.org/W2138989174","https://openalex.org/W2225425591","https://openalex.org/W2315224259","https://openalex.org/W2317737361","https://openalex.org/W4237120510","https://openalex.org/W4250611868"],"related_works":["https://openalex.org/W2034300098","https://openalex.org/W1993040323","https://openalex.org/W2138989174","https://openalex.org/W2102465686","https://openalex.org/W2739419110","https://openalex.org/W2072467743","https://openalex.org/W4386530582","https://openalex.org/W4297238391","https://openalex.org/W2300856748","https://openalex.org/W1939664008"],"abstract_inverted_index":{"This":[0],"study":[1],"investigated":[2],"the":[3,6,22,35,73,91,109,115,132,146,181,185,201,220,228,237,240],"potential":[4,238],"of":[5,59,84,96,112,145,170,184,219,227,239],"decellularized":[7,85],"human":[8,229],"umbilical":[9,43],"vein":[10],"(HUV)":[11],"as":[12,242],"an":[13,46,161,166],"allogeneic,":[14],"acellular":[15,75,162],"extracellular":[16],"matrix":[17],"(ECM)":[18],"scaffold":[19],"for":[20,57,79,247],"engineering":[21],"vocal":[23,64,230,248],"fold":[24,65,176,231,249],"lamina":[25,232],"propria":[26],"in":[27,108,114,206],"vitro.":[28],"HUV":[29,88],"specimens":[30],"with":[31,100,118,165,187,190,211],"Wharton's":[32,171],"jelly":[33,172],"on":[34,180],"abluminal":[36,182],"surface":[37,183],"were":[38,70,98,122,134,148,223],"uniformly":[39],"dissected":[40],"from":[41,67],"native":[42],"cords":[44],"using":[45,124,150],"automated":[47],"procedure":[48],"and":[49,77,86,90,94,103,120,139,216,251],"subjected":[50],"to":[51,195,225],"a":[52,151,243],"novel":[53],"saline-based":[54],"decellularization":[55,119],"treatment":[56],"removal":[58],"potentially":[60],"antigenic":[61],"epitopes.":[62],"Human":[63],"fibroblasts":[66,97,130,177],"primary":[68],"culture":[69],"seeded":[71],"onto":[72],"resulting":[74],"constructs":[76,89,116],"cultured":[78],"21":[80],"days.":[81],"The":[82,213],"structures":[83],"fibroblast-repopulated":[87,221],"attachment,":[92],"proliferation,":[93],"infiltration":[95,193],"examined":[99],"light":[101],"microscopy":[102],"scanning":[104],"electron":[105],"microscopy.":[106],"Changes":[107],"relative":[110],"densities":[111],"collagen":[113,207],"associated":[117],"recellularization":[121],"quantified":[123,140],"digital":[125],"image":[126],"analysis.":[127],"In":[128],"addition,":[129],"infiltrating":[131],"scaffolds":[133,147,222],"released":[135],"by":[136,141],"cell":[137],"recovery":[138],"counting.":[142],"Viscoelastic":[143],"properties":[144],"measured":[149],"linear,":[152],"simple-shear":[153],"rheometer":[154],"at":[155],"phonatory":[156],"frequencies.":[157],"Results":[158],"showed":[159],"that":[160],"ECM":[163],"construct":[164,186,241],"intact":[167],"three-dimensional":[168],"structure":[169],"was":[173,209],"fabricated.":[174],"Vocal":[175],"readily":[178],"attached":[179],"high":[188],"viability,":[189],"significant":[191,204],"cellular":[192],"up":[194],"approximately":[196],"600":[197],"microm":[198],"deep":[199],"into":[200],"construct.":[202],"A":[203],"increase":[205],"expression":[208],"observed":[210],"recellularization.":[212],"elastic":[214],"modulus":[215],"dynamic":[217],"viscosity":[218],"comparable":[224],"those":[226],"propria.":[233],"These":[234],"findings":[235],"supported":[236],"possible":[244],"surgical":[245],"allograft":[246],"restoration":[250],"reconstruction.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
