{"id":"https://openalex.org/W2000889981","doi":"https://doi.org/10.1101/gr.092726.109","title":"Copy number abnormalities in sporadic canine colorectal cancers","display_name":"Copy number abnormalities in sporadic canine colorectal cancers","publication_year":2010,"publication_date":"2010-01-19","ids":{"openalex":"https://openalex.org/W2000889981","doi":"https://doi.org/10.1101/gr.092726.109","mag":"2000889981","pmid":"https://pubmed.ncbi.nlm.nih.gov/20086242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840980"},"language":"en","primary_location":{"id":"doi:10.1101/gr.092726.109","doi":"https://doi.org/10.1101/gr.092726.109","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.092726.109","pdf_url":"http://genome.cshlp.org/content/20/3/341.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genome.cshlp.org/content/20/3/341.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013704258","display_name":"Jie Tang","orcid":"https://orcid.org/0000-0002-3991-2539","observed_orcids":["https://orcid.org/0000-0002-3991-2539","https://orcid.org/0000-0002-3538-4433"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Tang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109993901","display_name":"Shoshona Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoshona Le","raw_affiliation_strings":["Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30602, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024472624","display_name":"Liang Tso Sun","orcid":"https://orcid.org/0000-0002-7817-5121","observed_orcids":["https://orcid.org/0000-0002-7817-5121"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Sun","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109883194","display_name":"Xiuzhen Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiuzhen Yan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602,\n                           USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602,\n                           USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041651747","display_name":"Mucheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mucheng Zhang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602,\n                           USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602,\n                           USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer MacLeod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer MacLeod","raw_affiliation_strings":["School of Veterinary Medicine, University of California Davis, California 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, University of California Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006739290","display_name":"Bruce E. LeRoy","orcid":"https://orcid.org/0000-0002-4188-7336","observed_orcids":["https://orcid.org/0000-0002-4188-7336"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce LeRoy","raw_affiliation_strings":["College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013023953","display_name":"Nicole C. Northrup","orcid":"https://orcid.org/0000-0001-8793-3433","observed_orcids":["https://orcid.org/0000-0001-8793-3433"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Northrup","raw_affiliation_strings":["College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109767799","display_name":"Angela E. Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Ellis","raw_affiliation_strings":["College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113849367","display_name":"Timothy Joseph Yeatman","orcid":"https://orcid.org/0000-0002-7487-0784","observed_orcids":["https://orcid.org/0000-0002-7487-0784"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Yeatman","raw_affiliation_strings":["Departments of Surgery, Pathology, and Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida\n                           33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Pathology, and Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida\n                           33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102481087","display_name":"Yanchun Liang","orcid":"https://orcid.org/0009-0009-3069-5660","observed_orcids":["https://orcid.org/0009-0009-3069-5660"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanchun Liang","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011516354","display_name":"Michael E. Zwick","orcid":"https://orcid.org/0000-0001-9772-8257","observed_orcids":["https://orcid.org/0000-0001-9772-8257"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Zwick","raw_affiliation_strings":["Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30602, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108508978","display_name":"Shaying Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaying Zhao","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602,\n                           USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602,\n                           USA","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"341","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copy-number-abnormalities","display_name":"copy number abnormalities","score":0.9449999928474426},{"id":"https://openalex.org/keywords/comparative-oncology","display_name":"comparative oncology","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5649999976158142},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9480000138282776},{"id":"https://openalex.org/keywords/syntenic-regions","display_name":"syntenic regions","score":0.7599999904632568},{"id":"https://openalex.org/keywords/segmental-duplication","display_name":"segmental duplication","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8866857290267944},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.7035126686096191},{"id":"https://openalex.org/C53702515","wikidata":"https://www.wikidata.org/wiki/Q971246","display_name":"Synteny","level":4,"score":0.5995876789093018},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5938335657119751},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5903078317642212},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5466549396514893},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.5379559993743896},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5130397081375122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4995598793029785},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.48885244131088257},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4697582721710205},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.44343259930610657},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4303189516067505},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.41600242257118225},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.1758195459842682},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.15741229057312012},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.06664931774139404}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056916","descriptor_name":"Segmental Duplications, Genomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1101/gr.092726.109","doi":"https://doi.org/10.1101/gr.092726.109","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.092726.109","pdf_url":"http://genome.cshlp.org/content/20/3/341.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2840980","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840980","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Res","raw_type":"Text"},{"id":"pmid:20086242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20086242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:genome:20/3/341","doi":null,"is_oa":false,"landing_page_url":"http://genome.cshlp.org/cgi/content/short/20/3/341","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1101/gr.092726.109","doi":"https://doi.org/10.1101/gr.092726.109","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.092726.109","pdf_url":"http://genome.cshlp.org/content/20/3/341.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320309627","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000889981.pdf","grobid_xml":"https://content.openalex.org/works/W2000889981.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W73629738","https://openalex.org/W186058546","https://openalex.org/W1480376833","https://openalex.org/W1651093245","https://openalex.org/W1965680834","https://openalex.org/W1968002146","https://openalex.org/W1974107857","https://openalex.org/W1975407466","https://openalex.org/W1982767015","https://openalex.org/W1987447372","https://openalex.org/W1997493715","https://openalex.org/W1998670024","https://openalex.org/W1999403469","https://openalex.org/W2005958249","https://openalex.org/W2014546243","https://openalex.org/W2017927472","https://openalex.org/W2023568503","https://openalex.org/W2023705922","https://openalex.org/W2029878366","https://openalex.org/W2032247293","https://openalex.org/W2032432198","https://openalex.org/W2033328061","https://openalex.org/W2034269086","https://openalex.org/W2037416530","https://openalex.org/W2038078260","https://openalex.org/W2040454516","https://openalex.org/W2042482078","https://openalex.org/W2044838776","https://openalex.org/W2045040686","https://openalex.org/W2060084956","https://openalex.org/W2062691081","https://openalex.org/W2064349256","https://openalex.org/W2068858945","https://openalex.org/W2080308138","https://openalex.org/W2087099184","https://openalex.org/W2088748952","https://openalex.org/W2089467606","https://openalex.org/W2093531978","https://openalex.org/W2096145019","https://openalex.org/W2097710447","https://openalex.org/W2102314894","https://openalex.org/W2106982327","https://openalex.org/W2108627173","https://openalex.org/W2109303707","https://openalex.org/W2110065044","https://openalex.org/W2114611642","https://openalex.org/W2118294439","https://openalex.org/W2122769974","https://openalex.org/W2129843621","https://openalex.org/W2133374479","https://openalex.org/W2136119414","https://openalex.org/W2136549983","https://openalex.org/W2138155367","https://openalex.org/W2140970257","https://openalex.org/W2142640630","https://openalex.org/W2144371152","https://openalex.org/W2154546296","https://openalex.org/W2155170442","https://openalex.org/W2162119950","https://openalex.org/W2164984344","https://openalex.org/W2397728562","https://openalex.org/W2752885492","https://openalex.org/W2787894218","https://openalex.org/W3145128584","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1971024005","https://openalex.org/W2562068174","https://openalex.org/W2045624488","https://openalex.org/W2055737645","https://openalex.org/W2953959113","https://openalex.org/W6983838609","https://openalex.org/W2000254314","https://openalex.org/W1515142764","https://openalex.org/W2891532006","https://openalex.org/W4327843963"],"abstract_inverted_index":{"Human":[0],"colorectal":[1],"cancer":[2,15],"(CRC)":[3],"is":[4],"one":[5,46,247],"of":[6,14,47,73,90,102,131,141,171,239],"the":[7,12,48,67,91,105,112,125,132,138,160,181,188,193,198],"better-understood":[8],"systems":[9],"for":[10,25,54,66],"studying":[11],"genetics":[13],"initiation":[16],"and":[17,79,88,99,117,175,178,218,231],"progression.":[18],"To":[19],"develop":[20],"a":[21,70,168,236],"cross-species":[22],"comparison":[23],"strategy":[24],"identifying":[26],"CRC":[27,147],"causative":[28],"gene":[29],"or":[30],"genomic":[31,37,220],"alterations,":[32],"we":[33,83,135,166,201],"performed":[34],"array":[35],"comparative":[36],"hybridization":[38],"(aCGH)":[39],"to":[40,111,187,209],"investigate":[41],"copy":[42],"number":[43],"abnormalities":[44],"(CNAs),":[45],"most":[49],"prominent":[50],"lesion":[51],"types":[52],"reported":[53],"human":[55,80,103,133,146,174,230],"CRCs,":[56,104],"in":[57,96,144,159,246],"10":[58],"spontaneously":[59],"occurring":[60],"canine":[61,78,92,139,161,176],"CRCs.":[62,81],"The":[63],"results":[64],"revealed":[65],"first":[68],"time":[69],"strong":[71],"degree":[72],"genetic":[74],"homology":[75],"between":[76,86,173,229],"sporadic":[77],"First,":[82],"saw":[84],"that":[85,137,153,203,213,226],"5%":[87],"22%":[89],"genome":[93],"was":[94],"amplified/deleted":[95],"these":[97,154],"tumors,":[98,177],"that,":[100],"reminiscent":[101],"total":[106],"altered":[107,158],"sequences":[108],"directly":[109],"correlated":[110],"tumor's":[113],"progression":[114],"stage,":[115],"origin,":[116],"likely":[118],"microsatellite":[119],"instability":[120],"status.":[121],"Second,":[122],"when":[123],"mapping":[124],"identified":[126],"CNAs":[127,172,207,227,244],"onto":[128],"syntenic":[129],"regions":[130,212],"genome,":[134],"noted":[136],"orthologs":[140],"genes":[142],"participating":[143],"known":[145],"pathways":[148,155],"were":[149,184],"recurrently":[150],"disrupted,":[151],"indicating":[152],"might":[156],"be":[157],"CRCs":[162,233],"as":[163],"well.":[164],"Last,":[165],"observed":[167],"significant":[169],"overlapping":[170],"tumors":[179],"from":[180],"two":[182],"species":[183,248],"clustered":[185],"according":[186],"tumor":[189],"subtypes":[190],"but":[191],"not":[192],"species.":[194],"Significantly,":[195],"compared":[196,242],"with":[197,243],"shared":[199],"CNAs,":[200],"found":[202,245],"species-specific":[204],"(especially":[205],"human-specific)":[206],"localize":[208],"evolutionarily":[210],"unstable":[211],"harbor":[214],"more":[215],"segmental":[216],"duplications":[217],"interspecies":[219],"rearrangement":[221],"breakpoints.":[222],"These":[223],"findings":[224],"indicate":[225],"recurrent":[228],"dog":[232],"may":[234],"have":[235],"higher":[237],"probability":[238],"being":[240],"cancer-causative,":[241],"only.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
