{"id":"https://openalex.org/W2000887563","doi":"https://doi.org/10.1073/pnas.091109498","title":"S -nitrosothiol repletion by an inhaled gas regulates pulmonary function","display_name":"S -nitrosothiol repletion by an inhaled gas regulates pulmonary function","publication_year":2001,"publication_date":"2001-04-24","ids":{"openalex":"https://openalex.org/W2000887563","doi":"https://doi.org/10.1073/pnas.091109498","mag":"2000887563","pmid":"https://pubmed.ncbi.nlm.nih.gov/11320213"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.091109498","doi":"https://doi.org/10.1073/pnas.091109498","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.091109498","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/33292","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067877143","display_name":"M. Mart\u00ednez Moya","orcid":"https://orcid.org/0000-0002-4870-8169","observed_orcids":["https://orcid.org/0000-0002-4870-8169"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin P. Moya","raw_affiliation_strings":["Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021760409","display_name":"Andrew J. Gow","orcid":"https://orcid.org/0000-0003-0876-5158","observed_orcids":["https://orcid.org/0000-0003-0876-5158"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Gow","raw_affiliation_strings":["Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071651912","display_name":"T. McMahon","orcid":"https://orcid.org/0000-0002-3404-3223","observed_orcids":["https://orcid.org/0000-0002-3404-3223"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. McMahon","raw_affiliation_strings":["Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039280742","display_name":"Eric J. Toone","orcid":"https://orcid.org/0009-0003-5318-4106","observed_orcids":["https://orcid.org/0009-0003-5318-4106"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Toone","raw_affiliation_strings":["Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012994707","display_name":"Ira M. Cheifetz","orcid":"https://orcid.org/0000-0002-1174-1571","observed_orcids":["https://orcid.org/0000-0002-1174-1571"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira M. Cheifetz","raw_affiliation_strings":["Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107843336","display_name":"Ronald N. Goldberg","orcid":"https://orcid.org/0000-0002-5157-1263","observed_orcids":["https://orcid.org/0000-0002-5157-1263"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald N. Goldberg","raw_affiliation_strings":["Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060088000","display_name":"Jonathan S. Stamler","orcid":"https://orcid.org/0000-0002-6866-1572","observed_orcids":["https://orcid.org/0000-0002-6866-1572"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Stamler","raw_affiliation_strings":["Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal\u2013Perinatal Research Institute, Department of Pediatrics;\r Howard Hughes Medical Institute; and Departments of\r Medicine, Biochemistry, and\r Chemistry, Duke University Medical Center, Durham, NC\r 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6817,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.92694178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"98","issue":"10","first_page":"5792","last_page":"5797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-nitrosothiols","display_name":"S-nitrosothiols","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pulmonary-vasoconstriction","display_name":"pulmonary vasoconstriction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hypoxic-pulmonary-vasoconstriction","display_name":"hypoxic pulmonary vasoconstriction","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.5410000085830688},{"id":"https://openalex.org/keywords/ventilation-perfusion-matching","display_name":"ventilation-perfusion matching","score":0.7900000214576721},{"id":"https://openalex.org/keywords/airway-lining-fluid","display_name":"airway lining fluid","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.7710000276565552},{"id":"https://openalex.org/keywords/right-heart-failure","display_name":"right heart failure","score":0.671999990940094},{"id":"https://openalex.org/keywords/hypoxemia","display_name":"hypoxemia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8180000185966492},{"id":"https://openalex.org/keywords/nitric-oxide-toxicity","display_name":"nitric oxide toxicity","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C29323129","wikidata":"https://www.wikidata.org/wiki/Q3504897","display_name":"Hypoxic pulmonary vasoconstriction","level":3,"score":0.7974069118499756},{"id":"https://openalex.org/C2776779939","wikidata":"https://www.wikidata.org/wiki/Q1479485","display_name":"Hypoxemia","level":2,"score":0.6159806847572327},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5706642866134644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5553749203681946},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.49920654296875},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4931034743785858},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.48315805196762085},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.47876206040382385},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.45774856209754944},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.44836047291755676},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.42714935541152954},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4164943993091583},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.413551390171051},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3047199547290802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2513766288757324},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008623","descriptor_name":"Mercaptoethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008623","descriptor_name":"Mercaptoethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008623","descriptor_name":"Mercaptoethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009603","descriptor_name":"Nitroso Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009603","descriptor_name":"Nitroso Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009603","descriptor_name":"Nitroso Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026403","descriptor_name":"S-Nitrosothiols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026403","descriptor_name":"S-Nitrosothiols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026403","descriptor_name":"S-Nitrosothiols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.091109498","doi":"https://doi.org/10.1073/pnas.091109498","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.091109498","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:11320213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11320213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:180559","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC33292","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:33292","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/33292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:33292","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/33292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1481638738","https://openalex.org/W1488493608","https://openalex.org/W1489732236","https://openalex.org/W1580076592","https://openalex.org/W1825789202","https://openalex.org/W1964105983","https://openalex.org/W1980130533","https://openalex.org/W1980968493","https://openalex.org/W1982772851","https://openalex.org/W1986542934","https://openalex.org/W1996459741","https://openalex.org/W2001538146","https://openalex.org/W2004486757","https://openalex.org/W2007013508","https://openalex.org/W2010359959","https://openalex.org/W2010783235","https://openalex.org/W2014166332","https://openalex.org/W2018056489","https://openalex.org/W2026215531","https://openalex.org/W2028638263","https://openalex.org/W2029428162","https://openalex.org/W2029665946","https://openalex.org/W2034774541","https://openalex.org/W2037229372","https://openalex.org/W2040297517","https://openalex.org/W2047953482","https://openalex.org/W2054203419","https://openalex.org/W2054510493","https://openalex.org/W2056574789","https://openalex.org/W2058836844","https://openalex.org/W2082027250","https://openalex.org/W2087270114","https://openalex.org/W2088082611","https://openalex.org/W2089751994","https://openalex.org/W2095400859","https://openalex.org/W2120182098","https://openalex.org/W2121726342","https://openalex.org/W2135746849","https://openalex.org/W2152821471","https://openalex.org/W2161671586","https://openalex.org/W2253572376","https://openalex.org/W2323139294","https://openalex.org/W2340008871","https://openalex.org/W4285719527","https://openalex.org/W6701658658"],"related_works":["https://openalex.org/W1968092735","https://openalex.org/W1971056599","https://openalex.org/W1978590504","https://openalex.org/W2337180675","https://openalex.org/W2052281229","https://openalex.org/W2035612582","https://openalex.org/W3193337866","https://openalex.org/W3030558928","https://openalex.org/W2276702304","https://openalex.org/W2034373437"],"abstract_inverted_index":{"NO":[0,33,40,49,73,102,143,199],"synthases":[1],"are":[2,9,41,84],"widely":[3],"distributed":[4],"in":[5,12,43,56,63,77,174,185,190,208,220,256],"the":[6,13,25,29,66,78,97,118,148,194,217,265],"lung":[7,30,111,179,218],"and":[8,17,68,144,201,225,249,261],"extensively":[10],"involved":[11],"control":[14],"of":[15,28,39,70,80,101,150,153,160,178,236,270],"airway":[16,156],"vascular":[18],"homeostasis.":[19],"It":[20],"is":[21,75],"recognized,":[22],"however,":[23,121],"that":[24,99,214],"O(2)-rich":[26],"environment":[27],"may":[31,105,234,250,267],"predispose":[32],"toward":[34],"toxicity.":[35,112],"These":[36],"Janus":[37],"faces":[38],"manifest":[42],"recent":[44],"clinical":[45],"trials":[46],"with":[47,90,139,198,241],"inhaled":[48],"gas,":[50,132],"which":[51,83,135,145],"has":[52,94,122],"shown":[53],"therapeutic":[54,230,254],"benefit":[55,238],"some":[57],"patient":[58],"populations":[59],"but":[60],"increased":[61],"morbidity":[62],"others.":[64],"In":[65],"airways":[67,266],"circulation":[69],"humans,":[71],"most":[72],"bioactivity":[74],"packaged":[76],"form":[79],"S-nitrosothiols":[81],"(SNOs),":[82],"relatively":[85],"resistant":[86],"to":[87,96,115,223,239],"toxic":[88],"reactions":[89],"O(2)/O(2)(-).":[91],"This":[92],"finding":[93],"led":[95],"proposition":[98],"channeling":[100],"into":[103],"SNOs":[104,215],"provide":[106],"a":[107,131,175,206,252],"natural":[108],"defense":[109],"against":[110,205],"The":[113],"means":[114],"selectively":[116],"manipulate":[117],"SNO":[119,154],"pool,":[120],"not":[123,137],"been":[124],"previously":[125],"possible.":[126],"Here":[127],"we":[128],"report":[129],"on":[130,192],"O-nitrosoethanol":[133],"(ENO),":[134],"does":[136],"react":[138],"O(2)":[140],"or":[141,188],"release":[142],"markedly":[146],"increases":[147],"concentration":[149],"indigenous":[151],"species":[152],"within":[155,216],"lining":[157],"fluid.":[158],"Inhalation":[159],"ENO":[161,203,233],"provided":[162],"immediate":[163],"relief":[164],"from":[165],"hypoxic":[166],"pulmonary":[167,242],"vasoconstriction":[168],"without":[169],"affecting":[170],"systemic":[171],"hemodynamics.":[172],"Further,":[173],"porcine":[176],"model":[177],"injury,":[180],"there":[181],"was":[182],"no":[183],"rebound":[184],"cardiopulmonary":[186],"hemodynamics":[187],"fall":[189],"oxygenation":[191],"stopping":[193],"drug":[195],"(as":[196],"seen":[197],"gas),":[200],"additionally":[202],"protected":[204],"decline":[207],"cardiac":[209],"output.":[210],"Our":[211],"data":[212],"suggest":[213],"serve":[219],"matching":[221],"ventilation":[222],"perfusion,":[224],"can":[226],"be":[227,235,268],"manipulated":[228],"for":[229],"gain.":[231],"Thus,":[232],"particular":[237],"patients":[240],"hypertension,":[243],"hypoxemia,":[244],"and/or":[245],"right":[246],"heart":[247],"failure,":[248],"offer":[251],"new":[253],"approach":[255],"disorders":[257],"such":[258],"as":[259],"asthma":[260],"cystic":[262],"fibrosis,":[263],"where":[264],"depleted":[269],"SNOs.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}