{"id":"https://openalex.org/W2000883906","doi":"https://doi.org/10.1159/000091379","title":"Hierarchies of Extracellular Matrix and Mineral Organization in Bone of the Craniofacial Complex and Skeleton","display_name":"Hierarchies of Extracellular Matrix and Mineral Organization in Bone of the Craniofacial Complex and Skeleton","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2000883906","doi":"https://doi.org/10.1159/000091379","mag":"2000883906","pmid":"https://pubmed.ncbi.nlm.nih.gov/16612083"},"language":"en","primary_location":{"id":"doi:10.1159/000091379","doi":"https://doi.org/10.1159/000091379","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000091379","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030643977","display_name":"Marc D. McKee","orcid":"https://orcid.org/0000-0001-8349-965X","observed_orcids":["https://orcid.org/0000-0001-8349-965X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M.D. McKee","raw_affiliation_strings":["Faculty of Dentistry, McGill University, Montreal, QC, Canada. marc.mckee@mcgill.ca","Faculty of Dentistry, and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, McGill University, Montreal, QC, Canada. marc.mckee@mcgill.ca","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Faculty of Dentistry, and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046290174","display_name":"William N. Addison","orcid":"https://orcid.org/0000-0002-8587-8028","observed_orcids":["https://orcid.org/0000-0002-8587-8028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W.N. Addison","raw_affiliation_strings":["Faculty of Dentistry, and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, and Departments of","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085202255","display_name":"Mari T. Kaartinen","orcid":"https://orcid.org/0000-0003-2999-6502","observed_orcids":["https://orcid.org/0000-0003-2999-6502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.T. Kaartinen","raw_affiliation_strings":["Faculty of Dentistry, and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, and Departments of","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2637,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.12621359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"181","issue":"3-4","first_page":"176","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-matrix","display_name":"bone matrix","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hierarchy","display_name":"hierarchy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/craniofacial-bones","display_name":"craniofacial bones","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bone-matrix-proteins","display_name":"bone matrix proteins","score":0.5239999890327454},{"id":"https://openalex.org/keywords/apatite-nanocrystals","display_name":"apatite nanocrystals","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mineralization-inhibitors","display_name":"mineralization inhibitors","score":0.6869999766349792},{"id":"https://openalex.org/keywords/mechanical-properties-of-bone","display_name":"bone mechanical properties","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7228292226791382},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.6532137393951416},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.6507778763771057},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.49290966987609863},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.4879447817802429},{"id":"https://openalex.org/C2993697008","wikidata":"https://www.wikidata.org/wiki/Q1424568","display_name":"Bone matrix","level":3,"score":0.4875173270702362},{"id":"https://openalex.org/C154758884","wikidata":"https://www.wikidata.org/wiki/Q827742","display_name":"Mastication","level":2,"score":0.4688635468482971},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4478953778743744},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.41499167680740356},{"id":"https://openalex.org/C2777131851","wikidata":"https://www.wikidata.org/wiki/Q6864399","display_name":"Mineralized tissues","level":3,"score":0.41010645031929016},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37799328565597534},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3760780990123749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314769446849823},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3078221380710602},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.1899009346961975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10127273201942444},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.10041514039039612},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09823590517044067},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.08997154235839844},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.08626171946525574},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008903","descriptor_name":"Minerals","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000091379","doi":"https://doi.org/10.1159/000091379","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000091379","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},{"id":"pmid:16612083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16612083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells, tissues, organs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W48690109","https://openalex.org/W160739521","https://openalex.org/W194669671","https://openalex.org/W199897104","https://openalex.org/W592781805","https://openalex.org/W977626800","https://openalex.org/W1491030281","https://openalex.org/W1496931095","https://openalex.org/W1502955608","https://openalex.org/W1550732007","https://openalex.org/W1582049900","https://openalex.org/W1642501677","https://openalex.org/W1867374335","https://openalex.org/W1883442326","https://openalex.org/W1899123775","https://openalex.org/W1907379137","https://openalex.org/W1912515756","https://openalex.org/W1963539195","https://openalex.org/W1965619867","https://openalex.org/W1967455040","https://openalex.org/W1970270213","https://openalex.org/W1972590507","https://openalex.org/W1979007375","https://openalex.org/W1984612413","https://openalex.org/W1987708730","https://openalex.org/W1993487107","https://openalex.org/W1993763961","https://openalex.org/W1997210691","https://openalex.org/W1998837192","https://openalex.org/W2000359966","https://openalex.org/W2000413455","https://openalex.org/W2000834795","https://openalex.org/W2000972013","https://openalex.org/W2001121103","https://openalex.org/W2002928212","https://openalex.org/W2005936824","https://openalex.org/W2008544782","https://openalex.org/W2011648294","https://openalex.org/W2014097308","https://openalex.org/W2014733123","https://openalex.org/W2016752237","https://openalex.org/W2020990962","https://openalex.org/W2021191118","https://openalex.org/W2023238257","https://openalex.org/W2024372804","https://openalex.org/W2027264961","https://openalex.org/W2027378546","https://openalex.org/W2027420027","https://openalex.org/W2027712657","https://openalex.org/W2033289179","https://openalex.org/W2035212880","https://openalex.org/W2036806537","https://openalex.org/W2037499635","https://openalex.org/W2040768064","https://openalex.org/W2045783837","https://openalex.org/W2046349924","https://openalex.org/W2049290247","https://openalex.org/W2051208708","https://openalex.org/W2053168080","https://openalex.org/W2054635074","https://openalex.org/W2056825523","https://openalex.org/W2058628090","https://openalex.org/W2067261933","https://openalex.org/W2071337959","https://openalex.org/W2073068801","https://openalex.org/W2077792312","https://openalex.org/W2081129368","https://openalex.org/W2082446278","https://openalex.org/W2085789258","https://openalex.org/W2096728724","https://openalex.org/W2103215318","https://openalex.org/W2103602156","https://openalex.org/W2112698502","https://openalex.org/W2120498307","https://openalex.org/W2122171697","https://openalex.org/W2124802112","https://openalex.org/W2125028230","https://openalex.org/W2132305011","https://openalex.org/W2134135777","https://openalex.org/W2143470688","https://openalex.org/W2144207870","https://openalex.org/W2153149830","https://openalex.org/W2166149223","https://openalex.org/W2169170480","https://openalex.org/W2406793688","https://openalex.org/W2472955731","https://openalex.org/W2591854126","https://openalex.org/W4300065620"],"related_works":["https://openalex.org/W7171926927","https://openalex.org/W3208121973","https://openalex.org/W2086863316","https://openalex.org/W2127000141","https://openalex.org/W2800184149","https://openalex.org/W2496703842","https://openalex.org/W2119728491","https://openalex.org/W417926440","https://openalex.org/W1983728677","https://openalex.org/W2467765583"],"abstract_inverted_index":{"Structural":[0],"hierarchies":[1,90],"are":[2,8,28],"common":[3],"in":[4,11,77,118],"biologic":[5],"systems":[6],"and":[7,18,24,61,71,83,102,120],"particularly":[9],"evident":[10],"biomineralized":[12],"structures.":[13],"In":[14],"the":[15,36,40,44,67,112,122],"craniofacial":[16],"complex":[17],"skeleton":[19],"of":[20,26,47,51,59,91,115],"vertebrates,":[21],"extracellular":[22,92],"matrix":[23,58,93],"mineral":[25,53,116],"bone":[27,66,97],"structurally":[29],"ordered":[30],"at":[31],"many":[32],"dimensional":[33],"scales":[34],"from":[35],"macro":[37],"level":[38],"to":[39,65,75,108],"nano":[41],"level.":[42],"Indeed,":[43],"nanocomposite":[45],"texture":[46],"bone,":[48,119],"with":[49],"nanocrystals":[50],"apatitic":[52],"embedded":[54],"within":[55],"a":[56],"crosslinked":[57],"fibrillar":[60],"nonfibrillar":[62],"proteins,":[63],"imparts":[64],"very":[68],"mechanical":[69],"properties":[70],"toughness":[72],"it":[73],"needs":[74],"function":[76],"vital":[78],"organ":[79],"protection,":[80],"musculoskeletal":[81],"movement":[82],"mastication.":[84],"This":[85],"article":[86],"focuses":[87],"on":[88,111],"how":[89,121],"protein":[94],"organization":[95],"influence":[96],"cell":[98],"behavior,":[99],"tissue":[100],"architecture":[101],"mineralization.":[103],"Additional":[104],"attention":[105],"is":[106,125],"given":[107],"recent":[109],"work":[110],"molecular":[113],"determinants":[114],"induction":[117],"mineralization":[123],"process":[124],"subsequently":[126],"regulated":[127],"by":[128],"inhibitory":[129],"proteins.":[130]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}