{"id":"https://openalex.org/W2000879365","doi":"https://doi.org/10.1002/jcb.20558","title":"TGF\u2010\u03b2 control of cell proliferation","display_name":"TGF\u2010\u03b2 control of cell proliferation","publication_year":2005,"publication_date":"2005-08-08","ids":{"openalex":"https://openalex.org/W2000879365","doi":"https://doi.org/10.1002/jcb.20558","mag":"2000879365","pmid":"https://pubmed.ncbi.nlm.nih.gov/16088940"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.20558","doi":"https://doi.org/10.1002/jcb.20558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcb.20558","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20558","source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20558","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103431090","display_name":"Shuan Shian Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuan S. Huang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA. huangss@slu.edu","Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA. huangss@slu.edu","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089164683","display_name":"Jung San Huang","orcid":"https://orcid.org/0000-0001-9076-3156","observed_orcids":["https://orcid.org/0000-0001-9076-3156"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jung S. Huang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089164683"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":1.2201,"has_fulltext":true,"cited_by_count":222,"citation_normalized_percentile":{"value":0.7554965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"96","issue":"3","first_page":"447","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lrp1","display_name":"LRP1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.9629999995231628},{"id":"https://openalex.org/keywords/endocytic-pathway","display_name":"endocytic pathway","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.7269999980926514},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9190000295639038},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/protein-phosphatase","display_name":"protein phosphatase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.6579999923706055},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/met-signaling","display_name":"C-MET signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4740000069141388},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6697427034378052},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.622265636920929},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5596169829368591},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.5149053335189819},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4922904074192047},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.43948233127593994},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4006918668746948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0916542112827301}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcb.20558","doi":"https://doi.org/10.1002/jcb.20558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcb.20558","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20558","source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:16088940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16088940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"},{"id":"mag:2481309152","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Jung_Huang/publication/7671281_TGF-beta_control_of_cell_proliferation/links/543c085e0cf24a6ddb97d857.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1002/jcb.20558","doi":"https://doi.org/10.1002/jcb.20558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcb.20558","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20558","source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2514044356","display_name":"ROLES OF POLYPEPTIDE GROWTH FACTORS IN CELL GROWTH","funder_award_id":"R01CA038808","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000879365.pdf","grobid_xml":"https://content.openalex.org/works/W2000879365.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1564757063","https://openalex.org/W1565561072","https://openalex.org/W1642206810","https://openalex.org/W1663371441","https://openalex.org/W1968323673","https://openalex.org/W1974801498","https://openalex.org/W1974955986","https://openalex.org/W1975766417","https://openalex.org/W1978996505","https://openalex.org/W1980339625","https://openalex.org/W1984810049","https://openalex.org/W1986320148","https://openalex.org/W1993535707","https://openalex.org/W1999086610","https://openalex.org/W1999476309","https://openalex.org/W1999968358","https://openalex.org/W2003055074","https://openalex.org/W2005211274","https://openalex.org/W2008661593","https://openalex.org/W2010535091","https://openalex.org/W2012505775","https://openalex.org/W2016255628","https://openalex.org/W2016259832","https://openalex.org/W2020589003","https://openalex.org/W2023468848","https://openalex.org/W2030360428","https://openalex.org/W2035653659","https://openalex.org/W2036549271","https://openalex.org/W2039795116","https://openalex.org/W2041172831","https://openalex.org/W2042940542","https://openalex.org/W2044063704","https://openalex.org/W2045141910","https://openalex.org/W2045506998","https://openalex.org/W2049530394","https://openalex.org/W2053872302","https://openalex.org/W2057265410","https://openalex.org/W2058390591","https://openalex.org/W2060772749","https://openalex.org/W2077388392","https://openalex.org/W2079673122","https://openalex.org/W2082940206","https://openalex.org/W2096176385","https://openalex.org/W2098643301","https://openalex.org/W2101286042","https://openalex.org/W2103031848","https://openalex.org/W2115417003","https://openalex.org/W2147256404","https://openalex.org/W2149816215","https://openalex.org/W2150444415","https://openalex.org/W2156436523","https://openalex.org/W2160765823","https://openalex.org/W2160878816","https://openalex.org/W2419444252"],"related_works":["https://openalex.org/W2481309152","https://openalex.org/W3159636802","https://openalex.org/W2016259832","https://openalex.org/W2119593390","https://openalex.org/W2020977918","https://openalex.org/W2147256404","https://openalex.org/W1995987532","https://openalex.org/W4235005489","https://openalex.org/W3024117005","https://openalex.org/W2158075507"],"abstract_inverted_index":{"This":[0],"article":[1],"focuses":[2],"on":[3],"recent":[4,229],"findings":[5],"that":[6,39,84,106,254],"the":[7,91,142,156,173,191,204,236,246,252,259],"type":[8],"V":[9],"TGF-beta":[10,17,37,40,52,71,184,207,217,226,256],"receptor":[11,159,162],"(TbetaR-V),":[12],"which":[13,70,108],"co-expresses":[14],"with":[15,126,155],"other":[16,85,249],"receptors":[18],"(TbetaR-I,":[19],"TbetaR-II,":[20],"and":[21,36,38,50,64,119,128,134,165,187,193,211,224,248,258],"TbetaR-III)":[22],"in":[23,31,88,124,141,263],"all":[24],"normal":[25],"cell":[26,60,73],"types":[27],"studied,":[28],"is":[29,42,53,75,109,213],"involved":[30,140],"growth":[32,56,101,115,122,144,185,242],"inhibition":[33,116,123],"by":[34,44,69,117],"IGFBP-3":[35,118],"activity":[41],"regulated":[43],"two":[45,220],"distinct":[46,221],"endocytic":[47],"pathways":[48,223],"(clathrin-":[49],"caveolar/lipid-raft-mediated).":[51],"a":[54,135,214],"potent":[55],"inhibitor":[57],"for":[58,98],"most":[59],"types,":[61],"including":[62],"epithelial":[63],"endothelial":[65],"cells.":[66],"The":[67,148],"signaling":[68,86,94,146,150,167,175,250],"controls":[72,255],"proliferation":[74],"not":[76],"well":[77],"understood.":[78],"Many":[79],"lines":[80],"of":[81,172,195,206,261],"evidence":[82],"indicate":[83],"pathways,":[87],"addition":[89],"to":[90,111,153,181,190,209],"prominent":[92],"TbetaR-I/TbetaR-II/Smad2/3/4":[93],"cascade,":[95],"are":[96,139],"required":[97],"mediating":[99],"TGF-beta-induced":[100,121,240],"inhibition.":[102],"Recent":[103],"studies":[104,230],"revealed":[105],"TbetaR-V,":[107],"identical":[110],"LRP-1,":[112],"mediates":[113,120],"IGF-independent":[114],"concert":[125],"TbetaR-I":[127,212],"TbetaR-II.":[129],"In":[130],"addition,":[131],"IRS":[132],"proteins":[133],"Ser/Thr-specific":[136],"protein":[137],"phosphatase(s)":[138],"TbetaR-V-mediated":[143],"inhibitory":[145],"cascade.":[147],"TbetaR-V":[149,174,247,262],"cascade":[151,176],"appears":[152],"cross-talk":[154,244],"TbetaR-I/TbetaR-II,":[157],"insulin":[158],"(IR),":[160],"IGF-I":[161],"(IGF-IR),":[163],"integrin":[164],"c-Met":[166],"cascades.":[168],"Attenuation":[169],"or":[170],"loss":[171],"may":[177,188],"enable":[178],"carcinoma":[179],"cells":[180,197],"escape":[182],"from":[183],"control":[186],"contribute":[189],"aggressiveness":[192],"invasiveness":[194],"these":[196],"via":[198],"promoting":[199],"epithelial-to-mesenchymal":[200],"transdifferentiation":[201],"(EMT).":[202],"Finally,":[203],"ratio":[205],"binding":[208],"TbetaR-II":[210],"signal":[215,253],"controlling":[216],"partitioning":[218],"between":[219,245],"endocytosis":[222],"resultant":[225],"responsiveness.":[227],"These":[228],"have":[231],"provided":[232],"new":[233],"insights":[234],"into":[235],"molecular":[237],"mechanisms":[238],"underlying":[239],"cellular":[241],"inhibition,":[243],"cascades,":[251],"responsiveness":[257],"role":[260],"tumorigenesis.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}