{"id":"https://openalex.org/W2000878997","doi":"https://doi.org/10.1159/000186658","title":"Epidermal Growth Factor in Renal Hypertrophy in Streptozotocin-Diabetic Rats","display_name":"Epidermal Growth Factor in Renal Hypertrophy in Streptozotocin-Diabetic Rats","publication_year":2008,"publication_date":"2008-12-11","ids":{"openalex":"https://openalex.org/W2000878997","doi":"https://doi.org/10.1159/000186658","mag":"2000878997","pmid":"https://pubmed.ncbi.nlm.nih.gov/1766505"},"language":"en","primary_location":{"id":"doi:10.1159/000186658","doi":"https://doi.org/10.1159/000186658","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000186658","pdf_url":null,"source":{"id":"https://openalex.org/S4393917655","display_name":"The Nephron journals/Nephron journals","issn_l":"1660-8151","issn":["1660-8151","2235-3186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108482549","display_name":"Jinn\u2010Yuh Guh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jinn-Yuh Guh","raw_affiliation_strings":["Department of Internal Medicine, Kaohsiung Medical College, Taiwan","Departments of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Kaohsiung Medical College, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Departments of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110303277","display_name":"Yung\u2010Hsiung Lai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yung-Hsiung Lai","raw_affiliation_strings":["Departments of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004378090","display_name":"Shyi\u2010Jang Shin","orcid":"https://orcid.org/0000-0001-5074-8488","observed_orcids":["https://orcid.org/0000-0001-5074-8488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shyi-Jang Shin","raw_affiliation_strings":["Departments of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101635440","display_name":"Lea\u2010Yea Chuang","orcid":"https://orcid.org/0000-0001-8589-6210","observed_orcids":["https://orcid.org/0000-0001-8589-6210"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lea-Yea Chuang","raw_affiliation_strings":["Biochemistry, Kaohsiung Medical College, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, Kaohsiung Medical College, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111674334","display_name":"Juei\u2010Hsiung Tsai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juei-Hsiung Tsai","raw_affiliation_strings":["Departments of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2677,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.62898418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"59","issue":"4","first_page":"641","last_page":"647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/renal-hypertrophy","display_name":"renal hypertrophy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/diabetic-rats","display_name":"diabetic rats","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.86695396900177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8662769794464111},{"id":"https://openalex.org/C2909763481","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Renal Hypertrophy","level":4,"score":0.8041024804115295},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.790075421333313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7694138288497925},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7417446970939636},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5923212170600891},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5914939641952515},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5507059693336487},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5061356425285339},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.44339117407798767},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.38597795367240906},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07057109475135803}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000186658","doi":"https://doi.org/10.1159/000186658","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000186658","pdf_url":null,"source":{"id":"https://openalex.org/S4393917655","display_name":"The Nephron journals/Nephron journals","issn_l":"1660-8151","issn":["1660-8151","2235-3186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"journal-article"},{"id":"pmid:1766505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1766505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6600000262260437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417281057","https://openalex.org/W2070834681","https://openalex.org/W307617794","https://openalex.org/W2089078799","https://openalex.org/W2597007278","https://openalex.org/W2491674104","https://openalex.org/W2044943066","https://openalex.org/W2040415928","https://openalex.org/W47323136","https://openalex.org/W2076410201"],"abstract_inverted_index":{"Epidermal":[0],"growth":[1,179],"factor":[2],"(EGF)":[3],"concentrations":[4],"in":[5,28,32,42,48,65,73,82,85,100,112,132,142,181,184,195],"the":[6,24,33,43,49,58,66,74,88,101,113,133,143,162,165],"plasma,":[7],"kidneys":[8],"and":[9,15,60,123,153,171,183],"urine":[10,169],"of":[11,26,87,168],"31":[12],"streptozotocin-diabetic":[13],"rats":[14,19,68,103,115,135,145],"21":[16],"insulin-treated":[17,50,67,134],"diabetic":[18,34,44,59,75,114,144,196],"were":[20,78],"measured":[21],"to":[22,176],"study":[23],"role":[25],"EGF":[27,53,84,91,170,172,189],"initiating":[29],"renal":[30,178,193],"hypertrophy":[31,37,194],"rats.":[35,51,76,89,197],"Renal":[36,52],"occurred":[38],"from":[39,109],"day":[40,98,110,121,129,151,159],"7":[41,99],"rats,":[45,62],"but":[46,104],"not":[47,55],"was":[54,69,92,106,137],"different":[56],"between":[57],"control":[61,102],"while":[63,131],"that":[64,141,188],"significantly":[70,107,138],"less":[71,139],"than":[72,140],"There":[77],"no":[79],"significant":[80],"changes":[81],"plasma":[83],"any":[86],"Urine":[90],"119":[93],"+/-":[94,117,125,147,155],"7.9":[95],"ng/day":[96,119,127,149,157],"at":[97,120,128,150,158],"it":[105,136],"increased":[108],"2":[111,122,152],"(320":[116],"52.9":[118],"298":[124],"18.4":[126],"7),":[130],"(134":[146],"8.34":[148],"220":[154],"15.2":[156],"7).":[160],"Since":[161],"kidney":[163],"is":[164],"main":[166],"source":[167],"has":[173],"been":[174],"shown":[175],"induce":[177],"both":[180],"vitro":[182],"vivo,":[185],"we":[186],"conclude":[187],"may":[190],"have":[191],"initiated":[192]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}