{"id":"https://openalex.org/W2000878400","doi":"https://doi.org/10.1007/bf00812254","title":"Molecular mechanisms in T helper phenotype development","display_name":"Molecular mechanisms in T helper phenotype development","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2000878400","doi":"https://doi.org/10.1007/bf00812254","mag":"2000878400","pmid":"https://pubmed.ncbi.nlm.nih.gov/10666770"},"language":"en","primary_location":{"id":"doi:10.1007/bf00812254","doi":"https://doi.org/10.1007/bf00812254","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00812254","pdf_url":null,"source":{"id":"https://openalex.org/S22664439","display_name":"Springer Seminars in Immunopathology","issn_l":"0344-4325","issn":["0344-4325","1432-2196"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer Seminars in Immunopathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. D. Farrar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. D. Farrar","raw_affiliation_strings":["Department of Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007165528","display_name":"Sheila H. Ranganath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. H. Ranganath","raw_affiliation_strings":["Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St. Louis, MO, USA","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St. Louis, MO, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040420168","display_name":"KENNETH M. M. MURPHY","orcid":"https://orcid.org/0000-0002-3505-9630","observed_orcids":["https://orcid.org/0000-0002-3505-9630"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. M. Murphy","raw_affiliation_strings":["Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St. Louis, MO, USA","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St. Louis, MO, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0356,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.03709199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"3","first_page":"211","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.6520000100135803},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.546999990940094},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7080408334732056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5085095167160034},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47008633613586426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33243611454963684},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2885579466819763}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf00812254","doi":"https://doi.org/10.1007/bf00812254","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00812254","pdf_url":null,"source":{"id":"https://openalex.org/S22664439","display_name":"Springer Seminars in Immunopathology","issn_l":"0344-4325","issn":["0344-4325","1432-2196"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer Seminars in Immunopathology","raw_type":"journal-article"},{"id":"doi:10.1007/s002810050064","doi":"https://doi.org/10.1007/s002810050064","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s002810050064","pdf_url":null,"source":{"id":"https://openalex.org/S22664439","display_name":"Springer Seminars in Immunopathology","issn_l":"0344-4325","issn":["0344-4325","1432-2196"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer Seminars in Immunopathology","raw_type":"journal-article"},{"id":"pmid:10666770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10666770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer seminars in immunopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W61716574","https://openalex.org/W131140191","https://openalex.org/W236733732","https://openalex.org/W1497017413","https://openalex.org/W1497205974","https://openalex.org/W1498789037","https://openalex.org/W1504181275","https://openalex.org/W1520646806","https://openalex.org/W1521309261","https://openalex.org/W1522816379","https://openalex.org/W1535156928","https://openalex.org/W1588331058","https://openalex.org/W1592350719","https://openalex.org/W1601925808","https://openalex.org/W1604795805","https://openalex.org/W1607111607","https://openalex.org/W1623924764","https://openalex.org/W1634158134","https://openalex.org/W1811517392","https://openalex.org/W1817651135","https://openalex.org/W1823081504","https://openalex.org/W1830966545","https://openalex.org/W1836730957","https://openalex.org/W1838853754","https://openalex.org/W1882823390","https://openalex.org/W1883394179","https://openalex.org/W1894525365","https://openalex.org/W1958363133","https://openalex.org/W1970625093","https://openalex.org/W1978757502","https://openalex.org/W1979514172","https://openalex.org/W1979657237","https://openalex.org/W1981027928","https://openalex.org/W1982557722","https://openalex.org/W1985677612","https://openalex.org/W1987676683","https://openalex.org/W1987684167","https://openalex.org/W1987758746","https://openalex.org/W1987784311","https://openalex.org/W1988707760","https://openalex.org/W1988820544","https://openalex.org/W1989255771","https://openalex.org/W1990999119","https://openalex.org/W1991524518","https://openalex.org/W1994894837","https://openalex.org/W1995530329","https://openalex.org/W1997531619","https://openalex.org/W2001146686","https://openalex.org/W2001713238","https://openalex.org/W2002186586","https://openalex.org/W2003310898","https://openalex.org/W2006061341","https://openalex.org/W2006178861","https://openalex.org/W2011608246","https://openalex.org/W2011641869","https://openalex.org/W2012628280","https://openalex.org/W2015440478","https://openalex.org/W2016642606","https://openalex.org/W2019870550","https://openalex.org/W2021702586","https://openalex.org/W2026161448","https://openalex.org/W2027378848","https://openalex.org/W2027590165","https://openalex.org/W2027643215","https://openalex.org/W2027699993","https://openalex.org/W2028699958","https://openalex.org/W2029860358","https://openalex.org/W2030000864","https://openalex.org/W2030855216","https://openalex.org/W2031501484","https://openalex.org/W2033222990","https://openalex.org/W2038615458","https://openalex.org/W2041146582","https://openalex.org/W2041572572","https://openalex.org/W2041647537","https://openalex.org/W2043803403","https://openalex.org/W2044306159","https://openalex.org/W2044325609","https://openalex.org/W2046954690","https://openalex.org/W2047227568","https://openalex.org/W2051304739","https://openalex.org/W2051705414","https://openalex.org/W2052172628","https://openalex.org/W2052895824","https://openalex.org/W2055803387","https://openalex.org/W2058120223","https://openalex.org/W2058554631","https://openalex.org/W2058593261","https://openalex.org/W2063053561","https://openalex.org/W2067049479","https://openalex.org/W2067394439","https://openalex.org/W2068616722","https://openalex.org/W2070597700","https://openalex.org/W2072731639","https://openalex.org/W2072968746","https://openalex.org/W2075097313","https://openalex.org/W2078971599","https://openalex.org/W2083368737","https://openalex.org/W2084228983","https://openalex.org/W2086745302","https://openalex.org/W2088988430","https://openalex.org/W2091301099","https://openalex.org/W2091329062","https://openalex.org/W2094472942","https://openalex.org/W2094582124","https://openalex.org/W2100699905","https://openalex.org/W2101937406","https://openalex.org/W2102156468","https://openalex.org/W2103565638","https://openalex.org/W2107231521","https://openalex.org/W2107782053","https://openalex.org/W2107860814","https://openalex.org/W2109506765","https://openalex.org/W2112106256","https://openalex.org/W2112809104","https://openalex.org/W2120478829","https://openalex.org/W2121283723","https://openalex.org/W2121473086","https://openalex.org/W2122702335","https://openalex.org/W2124116262","https://openalex.org/W2124222608","https://openalex.org/W2124473841","https://openalex.org/W2127314810","https://openalex.org/W2128321311","https://openalex.org/W2134818464","https://openalex.org/W2135254713","https://openalex.org/W2135847617","https://openalex.org/W2136690547","https://openalex.org/W2139144899","https://openalex.org/W2140707292","https://openalex.org/W2140783929","https://openalex.org/W2141895910","https://openalex.org/W2144711633","https://openalex.org/W2145218870","https://openalex.org/W2149560334","https://openalex.org/W2151712105","https://openalex.org/W2151900684","https://openalex.org/W2152729998","https://openalex.org/W2154218327","https://openalex.org/W2155138543","https://openalex.org/W2155991561","https://openalex.org/W2161575486","https://openalex.org/W2164355279","https://openalex.org/W2165588484","https://openalex.org/W2165747007","https://openalex.org/W2168115358","https://openalex.org/W2168930459","https://openalex.org/W2171760349","https://openalex.org/W2171831396","https://openalex.org/W2177385981","https://openalex.org/W2468732126","https://openalex.org/W4235751459","https://openalex.org/W4313310005","https://openalex.org/W4313331188","https://openalex.org/W4313342428","https://openalex.org/W4313342465"],"related_works":["https://openalex.org/W7006016895","https://openalex.org/W2076278882","https://openalex.org/W2810584399","https://openalex.org/W1982996775","https://openalex.org/W1998244209","https://openalex.org/W1965617719","https://openalex.org/W2050853254","https://openalex.org/W1966653455","https://openalex.org/W1976434745","https://openalex.org/W1987924627"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
