{"id":"https://openalex.org/W2000872486","doi":"https://doi.org/10.1016/j.phymed.2009.03.019","title":"The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea","display_name":"The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea","publication_year":2009,"publication_date":"2009-05-08","ids":{"openalex":"https://openalex.org/W2000872486","doi":"https://doi.org/10.1016/j.phymed.2009.03.019","mag":"2000872486","pmid":"https://pubmed.ncbi.nlm.nih.gov/19423311"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2009.03.019","doi":"https://doi.org/10.1016/j.phymed.2009.03.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2009.03.019","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083996209","display_name":"Denise Brentan Silva","orcid":"https://orcid.org/0000-0003-0872-2756","observed_orcids":["https://orcid.org/0000-0003-0872-2756"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"D.B. da Silva","raw_affiliation_strings":["Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, SP, Brazil. debrentan@fcfrp.usp.br","Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto; Universidade de S\u00e3o Paulo; 14040-903 Ribeir\u00e3o Preto SP Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, SP, Brazil. debrentan@fcfrp.usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto; Universidade de S\u00e3o Paulo; 14040-903 Ribeir\u00e3o Preto SP Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029892485","display_name":"Elaine C. O. Tulli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122558511","display_name":"Universidade Federal de Mato Grosso do Sul","ror":"https://ror.org/0366d2847","country_code":"BR","type":"education","lineage":["https://openalex.org/I122558511"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"E.C.O. Tulli","raw_affiliation_strings":["Universidade Federal do Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil","institution_ids":["https://openalex.org/I122558511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038812136","display_name":"Gard\u00eania Carmen Gadelha Milit\u00e3o","orcid":"https://orcid.org/0000-0002-7865-5002","observed_orcids":["https://orcid.org/0000-0002-7865-5002"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"G.C.G. Milit\u00e3o","raw_affiliation_strings":["Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088398854","display_name":"Let\u00edcia Veras Costa-Lotufo","orcid":"https://orcid.org/0000-0003-1861-5153","observed_orcids":["https://orcid.org/0000-0003-1861-5153"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L.V. Costa-Lotufo","raw_affiliation_strings":["Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087731343","display_name":"Cl\u00e1udia Pessoa","orcid":"https://orcid.org/0000-0002-4344-4336","observed_orcids":["https://orcid.org/0000-0002-4344-4336"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C. Pessoa","raw_affiliation_strings":["Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694335","display_name":"Manoel Odorico de Moraes","orcid":"https://orcid.org/0000-0002-6826-8930","observed_orcids":["https://orcid.org/0000-0002-6826-8930"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M.O. de Moraes","raw_affiliation_strings":["Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Cear\u00e1, 60430-270 Fortaleza, CE, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087441402","display_name":"S\u00e9rgio de Albuquerque","orcid":"https://orcid.org/0000-0003-2530-9226","observed_orcids":["https://orcid.org/0000-0003-2530-9226"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S. Albuquerque","raw_affiliation_strings":["Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031233228","display_name":"Jo\u00e3o M\u00e1ximo de Siqueira","orcid":"https://orcid.org/0000-0002-2854-9383","observed_orcids":["https://orcid.org/0000-0002-2854-9383"]},"institutions":[{"id":"https://openalex.org/I166595947","display_name":"Federal University of S\u00e3o Jo\u00e3o del-Rei","ror":"https://ror.org/03vrj4p82","country_code":"BR","type":"education","lineage":["https://openalex.org/I166595947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J.M. de Siqueira","raw_affiliation_strings":["Universidade Federal de S\u00e3o Jo\u00e3o DelRei, 35501-273, Divin\u00f3polis, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Jo\u00e3o DelRei, 35501-273, Divin\u00f3polis, MG, Brazil","institution_ids":["https://openalex.org/I166595947"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083996209"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":1.8321,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.81368892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"11","first_page":"1059","last_page":"1063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12497","display_name":"Traditional and Medicinal Uses of Annonaceae","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12497","display_name":"Traditional and Medicinal Uses of Annonaceae","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duguetia-furfuracea","display_name":"Duguetia furfuracea","score":1.0},{"id":"https://openalex.org/keywords/annonaceae","display_name":"Annonaceae","score":0.9649999737739563},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.6539999842643738},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/trypanocidal-activity","display_name":"trypanocidal activity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antileishmanial-activity","display_name":"antileishmanial activity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/leishmania","display_name":"Leishmania","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.8037519454956055},{"id":"https://openalex.org/C2780303139","wikidata":"https://www.wikidata.org/wiki/Q220025","display_name":"Annonaceae","level":2,"score":0.7784939408302307},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6216005682945251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5656424760818481},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.562434196472168},{"id":"https://openalex.org/C2776635100","wikidata":"https://www.wikidata.org/wiki/Q582559","display_name":"Antiprotozoal","level":3,"score":0.5600190758705139},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5371933579444885},{"id":"https://openalex.org/C133446333","wikidata":"https://www.wikidata.org/wiki/Q38681","display_name":"Bark (sound)","level":2,"score":0.4622724950313568},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3341693878173828},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2980099320411682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2622310519218445},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2322443425655365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13327834010124207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06136929988861084},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007892","descriptor_name":"Leishmania braziliensis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029061","descriptor_name":"Annonaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.phymed.2009.03.019","doi":"https://doi.org/10.1016/j.phymed.2009.03.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2009.03.019","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:19423311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19423311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/20358","doi":null,"is_oa":false,"landing_page_url":"http://producao.usp.br/handle/BDPI/20358","pdf_url":null,"source":{"id":"https://openalex.org/S4306401373","display_name":"Scientific Electronic Library Online (S\u00e3o Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2982035970","host_organization_name":"Costa Rican Department of Social Security","host_organization_lineage":["https://openalex.org/I2982035970"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323354","display_name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","ror":"https://ror.org/05jtrt935"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W195243088","https://openalex.org/W1772829880","https://openalex.org/W1938454503","https://openalex.org/W1971193770","https://openalex.org/W1976146859","https://openalex.org/W1980399128","https://openalex.org/W1989421980","https://openalex.org/W1997711343","https://openalex.org/W2020551017","https://openalex.org/W2020700134","https://openalex.org/W2034664231","https://openalex.org/W2049606241","https://openalex.org/W2054564350","https://openalex.org/W2060235187","https://openalex.org/W2075808237","https://openalex.org/W2096197202","https://openalex.org/W2102851131","https://openalex.org/W2114918609","https://openalex.org/W2135664039","https://openalex.org/W2162331245","https://openalex.org/W2269074089"],"related_works":["https://openalex.org/W2032099902","https://openalex.org/W7120358438","https://openalex.org/W3105433581","https://openalex.org/W7208742007","https://openalex.org/W2092023218","https://openalex.org/W2164971949","https://openalex.org/W4380091339","https://openalex.org/W1964697593","https://openalex.org/W3193304167","https://openalex.org/W1984416223"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
