{"id":"https://openalex.org/W2000864697","doi":"https://doi.org/10.1016/0014-5793(92)81237-g","title":"Induction of vascular smooth muscle cell growth by selective activation of the thrombin receptor Effect of heparin","display_name":"Induction of vascular smooth muscle cell growth by selective activation of the thrombin receptor Effect of heparin","publication_year":1992,"publication_date":"1992-04-20","ids":{"openalex":"https://openalex.org/W2000864697","doi":"https://doi.org/10.1016/0014-5793(92)81237-g","mag":"2000864697","pmid":"https://pubmed.ncbi.nlm.nih.gov/1314739"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(92)81237-g","doi":"https://doi.org/10.1016/0014-5793(92)81237-g","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(92)81237-g","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2892%2981237-G","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2892%2981237-G","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111803452","display_name":"Jean\u2010Marc Herbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J.M. Herbert","raw_affiliation_strings":["Sanofi Recherche, Haemobiology Research Department, Toulouse, France","Sanofi Recherche, Haemobiology Research Department, 195 Route d'Espagne, 31036 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi Recherche, Haemobiology Research Department, Toulouse, France","institution_ids":["https://openalex.org/I3018075036"]},{"raw_affiliation_string":"Sanofi Recherche, Haemobiology Research Department, 195 Route d'Espagne, 31036 Toulouse, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Lamarche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Lamarche","raw_affiliation_strings":["Sanofi Recherche, Haemobiology Research Department, 195 Route d'Espagne, 31036 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi Recherche, Haemobiology Research Department, 195 Route d'Espagne, 31036 Toulouse, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111823626","display_name":"F. Dol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Dol","raw_affiliation_strings":["Sanofi Recherche, Haemobiology Research Department, 195 Route d'Espagne, 31036 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi Recherche, Haemobiology Research Department, 195 Route d'Espagne, 31036 Toulouse, France","institution_ids":["https://openalex.org/I3018075036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111803452"],"corresponding_institution_ids":["https://openalex.org/I3018075036"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":5.4859,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.96301893,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"301","issue":"2","first_page":"155","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-activated-receptor-1","display_name":"protease-activated receptor 1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/thrombin-receptor-agonist-peptide","display_name":"thrombin receptor agonist peptide","score":0.7120000123977661},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mitogenic-activity","display_name":"mitogenic activity","score":0.5249999761581421},{"id":"https://openalex.org/keywords/alpha-thrombin","display_name":"alpha-thrombin","score":0.7350000143051147},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pentosan-polysulphate","display_name":"pentosan polysulphate","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sulfated-polysaccharides","display_name":"sulfated polysaccharides","score":0.921999990940094},{"id":"https://openalex.org/keywords/molecular-weight-dependence","display_name":"molecular weight dependence","score":0.5440000295639038},{"id":"https://openalex.org/keywords/charge-dependence","display_name":"charge dependence","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.8979682922363281},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7438056468963623},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6979295015335083},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.638516366481781},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5613470077514648},{"id":"https://openalex.org/C2778886182","wikidata":"https://www.wikidata.org/wiki/Q24769535","display_name":"Thrombin receptor","level":4,"score":0.5594931244850159},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5489835739135742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4919681251049042},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47687870264053345},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4346717298030853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2748114764690399},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25467997789382935},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.18485918641090393},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.16746994853019714},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09785091876983643}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018179","descriptor_name":"Receptors, Thrombin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(92)81237-g","doi":"https://doi.org/10.1016/0014-5793(92)81237-g","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(92)81237-g","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2892%2981237-G","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:1314739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1314739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(92)81237-g","doi":"https://doi.org/10.1016/0014-5793(92)81237-g","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(92)81237-g","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2892%2981237-G","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000864697.pdf","grobid_xml":"https://content.openalex.org/works/W2000864697.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W190940606","https://openalex.org/W1663970427","https://openalex.org/W1979419562","https://openalex.org/W1990500910","https://openalex.org/W2020910725","https://openalex.org/W2033354476","https://openalex.org/W2038917226","https://openalex.org/W2043813981","https://openalex.org/W2055366835","https://openalex.org/W2057004885","https://openalex.org/W2061755142","https://openalex.org/W2071184125","https://openalex.org/W2077924600","https://openalex.org/W2081753893","https://openalex.org/W2153852857"],"related_works":["https://openalex.org/W2166170833","https://openalex.org/W2415120447","https://openalex.org/W1945643628","https://openalex.org/W2077714106","https://openalex.org/W2012113693","https://openalex.org/W2315213959","https://openalex.org/W2081210866","https://openalex.org/W2144444239","https://openalex.org/W1976300141","https://openalex.org/W2157996537"],"abstract_inverted_index":{"The":[0],"synthetic":[1,71],"peptide,":[2],"SFLLRNPNDKYEPF,":[3],"has":[4],"been":[5],"recently":[6],"described":[7],"as":[8,24,49,187],"a":[9,34,70],"peptide":[10,32,145],"mimicking":[11],"the":[12,19,28,46,57,74,95,99,107,139,143,158,172,176],"new":[13],"amino-terminus":[14],"created":[15],"by":[16],"cleavage":[17],"of":[18,27,51,59,73,77,98,110,142,161,175],"thrombin":[20,29],"receptor,":[21],"therefore":[22,104],"acting":[23],"an":[25],"agonist":[26,100,144],"receptor.":[30],"This":[31,152],"was":[33,91,129,154,164,179],"potent":[35],"mitogen":[36],"for":[37,112,182],"rabbit":[38],"arterial":[39],"smooth":[40],"muscle":[41],"cells":[42],"(SMC)":[43],"and":[44,170,178],"exhibited":[45],"same":[47],"activity":[48,76,160],"that":[50,106],"native":[52],"alpha-thrombin.":[53],"Both":[54],"compounds":[55],"stimulated":[56],"proliferation":[58],"growth-arrested":[60],"SMCs":[61,113],"with":[62],"half-maximum":[63],"mitogenic":[64,96,108,140],"responses":[65],"at":[66],"1":[67],"nM.":[68],"NAPAP,":[69],"inhibitor":[72],"enzymatic":[75],"thrombin,":[78],"specifically":[79],"inhibited":[80,123],"thrombin-induced":[81,133],"SMC":[82,127,134],"growth":[83,135],"(IC50":[84,146],"=":[85,147],"0.35":[86],"+/-":[87,149],"0.04":[88],"microM)":[89],"but":[90,136,163],"without":[92,130],"effect":[93,97,109,131,141,153],"on":[94,132,167,171],"peptide.":[101],"These":[102],"results":[103],"demonstrate":[105],"alpha-thrombin":[111],"is":[114],"intimately":[115],"linked":[116],"to":[117,157],"its":[118],"esterolytic":[119],"activity.":[120],"Heparin,":[121],"which":[122],"fetal":[124],"calf":[125],"serum-induced":[126],"growth,":[128],"strongly":[137],"reduced":[138],"32":[148],"5":[150],"micrograms/ml).":[151],"not":[155],"related":[156],"anti-coagulant":[159],"heparin":[162],"highly":[165],"dependent":[166],"molecular":[168],"mass":[169],"global":[173],"charge":[174],"molecule":[177],"also":[180],"observed":[181],"other":[183],"sulphated":[184],"polysaccharides":[185],"such":[186],"pentosan":[188],"polysulphate.":[189]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
