{"id":"https://openalex.org/W2000864533","doi":"https://doi.org/10.1111/j.1939-1676.2008.0230.x","title":"Ascites is a Negative Prognostic Indicator in Chronic Hepatitis in Dogs","display_name":"Ascites is a Negative Prognostic Indicator in Chronic Hepatitis in Dogs","publication_year":2008,"publication_date":"2008-11-27","ids":{"openalex":"https://openalex.org/W2000864533","doi":"https://doi.org/10.1111/j.1939-1676.2008.0230.x","mag":"2000864533","pmid":"https://pubmed.ncbi.nlm.nih.gov/19175722"},"language":"en","primary_location":{"id":"doi:10.1111/j.1939-1676.2008.0230.x","doi":"https://doi.org/10.1111/j.1939-1676.2008.0230.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2008.0230.x","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027584095","display_name":"Eleanor Raffan","orcid":"https://orcid.org/0000-0002-1403-3538","observed_orcids":["https://orcid.org/0000-0002-1403-3538"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"E. Raffan","raw_affiliation_strings":["University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072517116","display_name":"Audrey L. McCallum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. McCallum","raw_affiliation_strings":["University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057320173","display_name":"Timothy J. Scase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T.J. Scase","raw_affiliation_strings":["University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041331503","display_name":"Penny Watson","orcid":"https://orcid.org/0000-0002-7241-9412","observed_orcids":["https://orcid.org/0000-0002-7241-9412"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.J. Watson","raw_affiliation_strings":["University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Queen's Veterinary School Hospital, Department of Veterinary Medicine, , Cambridge,","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027584095"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":2.221,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.85312754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"63","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9520000219345093},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.7369999885559082},{"id":"https://openalex.org/keywords/spironolactone","display_name":"spironolactone","score":0.9409999847412109},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.5770000219345093},{"id":"https://openalex.org/keywords/clinical-decision-making","display_name":"clinical decision-making","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9738166928291321},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.8006154298782349},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5362673401832581},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49699071049690247},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4562793970108032},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4427911043167114},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24762210249900818},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.13451114296913147}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001201","descriptor_name":"Ascites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001201","descriptor_name":"Ascites","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006520","descriptor_name":"Hepatitis, Animal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1939-1676.2008.0230.x","doi":"https://doi.org/10.1111/j.1939-1676.2008.0230.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2008.0230.x","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"pmid:19175722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19175722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9528999924659729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W30638042","https://openalex.org/W47820555","https://openalex.org/W1771158870","https://openalex.org/W1970600277","https://openalex.org/W2050232332","https://openalex.org/W2081660399","https://openalex.org/W2082823523","https://openalex.org/W2087141990","https://openalex.org/W2089049107","https://openalex.org/W2094338232","https://openalex.org/W2141950160","https://openalex.org/W2144187699","https://openalex.org/W2149188561","https://openalex.org/W2163037460","https://openalex.org/W2169931914","https://openalex.org/W2187668060","https://openalex.org/W2254315775","https://openalex.org/W2290195878","https://openalex.org/W2323317400","https://openalex.org/W2417994050","https://openalex.org/W2611268027","https://openalex.org/W2995133996","https://openalex.org/W3147894994","https://openalex.org/W4231672841","https://openalex.org/W4238894080","https://openalex.org/W4247948632","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2986177860","https://openalex.org/W4244487079","https://openalex.org/W1970600277","https://openalex.org/W7204148548","https://openalex.org/W7119491511","https://openalex.org/W2163037460","https://openalex.org/W3140413098","https://openalex.org/W3171532477","https://openalex.org/W2168984471","https://openalex.org/W165582969"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"hepatitis":[2],"(CH)":[3],"in":[4,24,33,35,109,196,212],"dogs":[5,39,117,138,146,167,175,197],"is":[6,10,18,28,190],"common":[7],"but":[8],"little":[9],"known":[11],"about":[12],"factors":[13],"associated":[14],"with":[15,40,79,198],"survival.":[16],"Ascites":[17,27,69,189],"a":[19,29,191],"well-recognized":[20],"negative":[21,30,193],"prognostic":[22,31,194],"indicator":[23,32,195],"humans.":[25],"HYPOTHESIS:":[26],"CH":[34,43,56],"dogs.":[36,214],"ANIMALS:":[37],"Thirty-four":[38],"histologically":[41],"confirmed":[42],"presented":[44],"to":[45,65,123,155,207],"1":[46],"institution":[47],"between":[48,183],"1996":[49],"and":[50,101,111,139,150,168,179,201],"2005.":[51],"METHODS:":[52],"Retrospective":[53],"observational":[54],"study.":[55],"was":[57,70,98,128,160],"diagnosed":[58,71],"by":[59,72],"histopathology":[60],"of":[61,77,85,115,153],"liver":[62,96,126,158],"tissue":[63],"according":[64],"the":[66],"WSAVA":[67],"criteria.":[68],"abdominal":[73],"ultrasound.":[74],"The":[75],"association":[76],"ascites":[78],"survival":[80],"from":[81,91,95,121,125,151,157],"diagnosis":[82,122],"or":[83,94],"onset":[84,152],"owner-reported":[86],"clinical":[87,209],"signs":[88,154],"until":[89],"death":[90,124,156],"any":[92],"cause":[93],"disease":[97,127,159],"analyzed.":[99],"Ascitic":[100],"nonascitic":[102,145,174],"groups":[103],"were":[104],"further":[105],"analyzed":[106],"for":[107,136,144,165,173],"differences":[108],"treatment":[110],"sex.":[112],"RESULTS:":[113],"Fourteen":[114],"34":[116],"had":[118],"ascites.":[119],"Survival":[120],"0.4":[129],"months":[130,141,162,170],"(95%":[131],"confidence":[132],"interval":[133],"[CI],":[134],"0.2-0.6)":[135],"ascitic":[137,166],"24.3":[140],"(CI":[142,163,171],"11.4-37.1)":[143],"(P":[147],"<":[148],".001),":[149],"2.0":[161],"0.0-5.6)":[164],"33.0":[169],"8.6-57.4)":[172],"(P=":[176],".0020).":[177],"Diet":[178],"spironolactone":[180],"use":[181,204],"differed":[182],"groups.":[184],"CONCLUSIONS":[185],"AND":[186],"CLINICAL":[187],"IMPORTANCE:":[188],"significant":[192],"CH.":[199],"Veterinarians":[200],"owners":[202],"can":[203],"this":[205],"information":[206],"aid":[208],"decision":[210],"making":[211],"affected":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}