{"id":"https://openalex.org/W2000862310","doi":"https://doi.org/10.1210/jcem-47-1-126","title":"Radioimmunoassay of Human Thyroglobulin: Effect of Antithyroglobulin Autoantibodies*","display_name":"Radioimmunoassay of Human Thyroglobulin: Effect of Antithyroglobulin Autoantibodies*","publication_year":1978,"publication_date":"1978-07-01","ids":{"openalex":"https://openalex.org/W2000862310","doi":"https://doi.org/10.1210/jcem-47-1-126","mag":"2000862310","pmid":"https://pubmed.ncbi.nlm.nih.gov/263287"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-47-1-126","doi":"https://doi.org/10.1210/jcem-47-1-126","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-47-1-126","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038843599","display_name":"Arthur B. Schneider","orcid":"https://orcid.org/0000-0001-5971-7469","observed_orcids":["https://orcid.org/0000-0001-5971-7469"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ARTHUR B. SCHNEIDER","raw_affiliation_strings":["Michael Reese Hospital and Medical Center, University of Chicago School of Medicine Chicago, Illinois 60616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michael Reese Hospital and Medical Center, University of Chicago School of Medicine Chicago, Illinois 60616","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022795339","display_name":"Richard Pervos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RICHARD PERVOS","raw_affiliation_strings":["Michael Reese Hospital and Medical Center, University of Chicago School of Medicine Chicago, Illinois 60616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michael Reese Hospital and Medical Center, University of Chicago School of Medicine Chicago, Illinois 60616","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":7.0353,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.96986727,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"1","first_page":"126","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anti-thyroglobulin-antibodies","display_name":"thyroglobulin antibodies","score":0.8999999761581421},{"id":"https://openalex.org/keywords/radioimmunoassay-interference","display_name":"radioimmunoassay interference","score":0.921999990940094},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sample-volume","display_name":"sample volume","score":0.609000027179718},{"id":"https://openalex.org/keywords/thyroid-autoimmunity","display_name":"thyroid autoimmunity","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.8482921719551086},{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.8128221035003662},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7922104597091675},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.7504940032958984},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6730685234069824},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5756012797355652},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5130009055137634},{"id":"https://openalex.org/C34343649","wikidata":"https://www.wikidata.org/wiki/Q1548862","display_name":"Hemagglutination","level":3,"score":0.5041307210922241},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33398354053497314},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2883688807487488},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2617315649986267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21969518065452576}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-47-1-126","doi":"https://doi.org/10.1210/jcem-47-1-126","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-47-1-126","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:263287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/263287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W28700328","https://openalex.org/W168181547","https://openalex.org/W202175617","https://openalex.org/W1518948065","https://openalex.org/W1638410479","https://openalex.org/W1967983161","https://openalex.org/W1971206609","https://openalex.org/W1981090278","https://openalex.org/W2023307232","https://openalex.org/W2026129487","https://openalex.org/W2038548816","https://openalex.org/W2050951459","https://openalex.org/W2060701359","https://openalex.org/W2061415412","https://openalex.org/W2115246016","https://openalex.org/W2118853852","https://openalex.org/W2124524123","https://openalex.org/W2137314136","https://openalex.org/W2399049489"],"related_works":["https://openalex.org/W2400886982","https://openalex.org/W2410836214","https://openalex.org/W1973566446","https://openalex.org/W2141782751","https://openalex.org/W1972043730","https://openalex.org/W1980122494","https://openalex.org/W7207383091","https://openalex.org/W2109059809","https://openalex.org/W2048413452","https://openalex.org/W7097296565"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,49,63,78,96,116,141,149,201],"designed":[3],"to":[4,26,88,164,185,212,240,244],"investigate":[5],"quantitatively":[6],"the":[7,13,41,67,73,76,79,82,93,104,109,112,120,127,130,134,158,161,176,186,204,235,246,261,266,269,273,277,283],"interference":[8,77,131,259],"of":[9,15,75,81,129,152,160,190,237,248,268],"thyroglobulin":[10,17],"autoantibodies":[11,20],"in":[12,40,71,108,260],"RIA":[14,263],"human":[16,60,102,125,167],"(hTG).":[18],"Anti-hTG":[19,169],"were":[21,38],"combined":[22],"with":[23,29,86,124,166,215],"purified":[24],"hTG":[25,34,58,114,154,191,262],"produce":[27],"samples":[28,37,214],"known":[30],"antibody":[31],"titers":[32,170,218],"and":[33,59,111,281],"concentrations.":[35],"These":[36],"analyzed":[39],"RIA.":[42],"By":[43],"using":[44],"anti-human":[45],"globulin":[46],"serum":[47],"it":[48],"first":[50],"shown":[51,65],"that":[52,66,250],"immune":[53,90,105],"complexes":[54,106],"formed":[55],"between":[56],"labeled":[57],"anti-hTG.":[61],"It":[62,226],"then":[64],"most":[68],"important":[69],"factor":[70],"determining":[72],"direction":[74,128],"specificity":[80,267],"precipitating":[83,94,121,162,199,270],"(second)":[84],"antiserum":[85,95,122,163,200],"respect":[87],"these":[89],"complexes.":[91],"When":[92,119],"specific,":[97],"i.e.":[98],"did":[99],"not":[100,193,224],"recognize":[101],"antibodies,":[103,126],"remained":[107],"supernatant":[110],"measured":[113],"concentration":[115],"falsely":[117],"elevated.":[118],"cross-reacted":[123],"depended":[132],"on":[133,157],"sample":[135,274],"volume.":[136],"At":[137],"small":[138],"volumes":[139,147],"there":[140,148],"false":[142,150],"depression":[143],"while":[144],"at":[145],"large":[146,183],"elevation":[151],"apparent":[153],"levels,":[155],"depending":[156],"capacity":[159],"combine":[165],"antibodies.":[168],"far":[171],"below":[172],"those":[173],"detected":[174],"by":[175],"tanned-red":[177],"cell":[178],"hemagglutination":[179,217],"test":[180],"had":[181],"very":[182],"effects,":[184],"point":[187],"where":[188],"measurements":[189],"could":[192],"be":[194,252],"made,":[195],"when":[196],"a":[197],"cross-reactive":[198],"used.":[202],"Therefore,":[203],"procedure":[205],"which":[206,233,256],"investigators":[207],"have":[208],"used":[209],"until":[210,229],"now,":[211],"exclude":[213],"anti-hTG":[216,249,258,284],"above":[219],"an":[220],"arbitrary":[221],"limit,":[222],"is":[223,227],"adequate.":[225],"necessary,":[228],"methods":[230],"are":[231,264],"developed":[232],"avoid":[234],"problem":[236],"autoantibody":[238],"interference,":[239],"characterize":[241],"each":[242],"assay":[243],"determine":[245],"limits":[247],"can":[251],"tolerated.":[253],"The":[254],"factors":[255],"influence":[257],"1)":[265],"antiserum,":[271],"2)":[272],"volume,":[275],"3)":[276],"maximum":[278],"tracer":[279],"binding,":[280],"4)":[282],"titer.":[285]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}