{"id":"https://openalex.org/W2000859155","doi":"https://doi.org/10.1248/cpb.49.361","title":"Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 3. Synthesis and Evaluation of 5-Thiocarbamate Oxazolidinones.","display_name":"Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 3. Synthesis and Evaluation of 5-Thiocarbamate Oxazolidinones.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2000859155","doi":"https://doi.org/10.1248/cpb.49.361","mag":"2000859155","pmid":"https://pubmed.ncbi.nlm.nih.gov/11310658"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.49.361","doi":"https://doi.org/10.1248/cpb.49.361","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.49.361","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/49/4/49_4_361/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/cpb/49/4/49_4_361/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064905733","display_name":"Ryukou Tokuyama","orcid":"https://orcid.org/0000-0002-2424-1920","observed_orcids":["https://orcid.org/0000-0002-2424-1920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryukou TOKUYAMA","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029352181","display_name":"Yoshiei TAKAHASHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiei TAKAHASHI","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040814616","display_name":"Yayoi Tomita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yayoi TOMITA","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057541800","display_name":"Masatoshi Tsubouchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masatoshi TSUBOUCHI","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057708246","display_name":"Nobuhiko Iwasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuhiko IWASAKI","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088966592","display_name":"Noriyuki Kado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noriyuki KADO","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109964406","display_name":"Eiichi Okezaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eiichi OKEZAKI","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067834903","display_name":"Osamu Nagata","orcid":"https://orcid.org/0000-0002-2988-8977","observed_orcids":["https://orcid.org/0000-0002-2988-8977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Osamu NAGATA","raw_affiliation_strings":["Research and Development Division, Hokuriku Seiyaku Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Hokuriku Seiyaku Co., Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0608,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.8400103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"49","issue":"4","first_page":"361","last_page":"367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5077999830245972,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5077999830245972,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14459","display_name":"Synthesis and Reactions of Organic Compounds","score":0.22139999270439148,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxazolidinones","display_name":"oxazolidinones","score":0.8410000205039978},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9509999752044678},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.9729999899864197},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/vancomycin-resistant-enterococci","display_name":"vancomycin-resistant enterococci","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.949999988079071},{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":0.7329999804496765},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2780520622","wikidata":"https://www.wikidata.org/wiki/Q413606","display_name":"Thiocarbamate","level":2,"score":0.9362077116966248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9130756855010986},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.6511408686637878},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.5667216777801514},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.48215338587760925},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.47026142477989197},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43294912576675415},{"id":"https://openalex.org/C2911014270","wikidata":"https://www.wikidata.org/wiki/Q413606","display_name":"Thiocarbamates","level":2,"score":0.4324977993965149},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3353198170661926},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3297743797302246},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.283061683177948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2681664228439331},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26326650381088257},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21006235480308533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/cpb.49.361","doi":"https://doi.org/10.1248/cpb.49.361","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.49.361","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/49/4/49_4_361/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:11310658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11310658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/cpb.49.361","doi":"https://doi.org/10.1248/cpb.49.361","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.49.361","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/49/4/49_4_361/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000859155.pdf","grobid_xml":"https://content.openalex.org/works/W2000859155.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W363209287","https://openalex.org/W1974806459","https://openalex.org/W1993838378","https://openalex.org/W2000909844","https://openalex.org/W2162408730","https://openalex.org/W2165797716","https://openalex.org/W2168635615","https://openalex.org/W4230852434"],"related_works":["https://openalex.org/W2162408730","https://openalex.org/W2949993847","https://openalex.org/W2950422876","https://openalex.org/W2165797716","https://openalex.org/W2166716436","https://openalex.org/W2949667701","https://openalex.org/W2012206896","https://openalex.org/W1992574152","https://openalex.org/W4317209607","https://openalex.org/W2063598167"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,19,98],"5-thiocarbamate":[3,27],"oxazolidinones":[4],"was":[5,29],"prepared":[6],"and":[7,12,65,71,81,85],"tested":[8],"for":[9,33],"in":[10,13,20,53,77,79,82,101],"vitro":[11,21,54,80],"vivo":[14,83],"antibacterial":[15,22,55],"activities.":[16],"The":[17,40],"results":[18],"activity":[23,35,56],"indicated":[24],"that":[25],"the":[26,34,37,95],"group":[28],"a":[30,43],"suitable":[31],"substituent":[32],"by":[36],"5-moderate":[38],"hydrophilicity.":[39],"compounds":[41,100],"within":[42],"favorable":[44],"logP":[45],"value":[46],"range":[47],"were":[48,73,86],"found":[49],"to":[50,75,88],"have":[51],"potent":[52],"against":[57],"gram-positive":[58],"bacteria":[59],"including":[60],"methicillin-resistant":[61],"Staphylococcus":[62],"aureus":[63],"(MRSA)":[64],"vancomycin-resistant":[66],"enterococci":[67],"(VRE).":[68],"Compounds":[69],"3a":[70],"4h":[72],"superior":[74],"linezolid":[76],"both":[78],"potency":[84],"considered":[87],"be":[89],"hopeful":[90],"compounds.":[91],"We":[92],"also":[93],"discuss":[94],"pharmacokinetic":[96],"properties":[97],"several":[99],"mice.":[102]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
