{"id":"https://openalex.org/W2000853441","doi":"https://doi.org/10.1002/hep.510300419","title":"In situ nucleic acid detection of human telomerase in intrahepatic cholangiocarcinoma and its preneoplastic lesion","display_name":"In situ nucleic acid detection of human telomerase in intrahepatic cholangiocarcinoma and its preneoplastic lesion","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2000853441","doi":"https://doi.org/10.1002/hep.510300419","mag":"2000853441","pmid":"https://pubmed.ncbi.nlm.nih.gov/10498642"},"language":"en","primary_location":{"id":"doi:10.1002/hep.510300419","doi":"https://doi.org/10.1002/hep.510300419","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.510300419","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510300419","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510300419","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032030704","display_name":"Satoru Ozaki","orcid":"https://orcid.org/0000-0002-2322-8804","observed_orcids":["https://orcid.org/0000-0002-2322-8804"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I2802874812","display_name":"Caritas Medical Centre","ror":"https://ror.org/01zqztb27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2802874812"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Satoru Ozaki","raw_affiliation_strings":["Department of Pathology (II), Kanazawa University School of Medicine, Kanazawa, Japan","Department of Clinical Laboratory, National Hospital of Kanazawa, Kanazawa, Japan","Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology (II), Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Clinical Laboratory, National Hospital of Kanazawa, Kanazawa, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I2802874812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008794738","display_name":"Kenichi Harada","orcid":"https://orcid.org/0000-0002-6451-0638","observed_orcids":["https://orcid.org/0000-0002-6451-0638"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I2802874812","display_name":"Caritas Medical Centre","ror":"https://ror.org/01zqztb27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2802874812"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Kenichi Harada","raw_affiliation_strings":["Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I2802874812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000457213","display_name":"Takahiro Sanzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I2802874812","display_name":"Caritas Medical Centre","ror":"https://ror.org/01zqztb27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2802874812"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Takahiro Sanzen","raw_affiliation_strings":["Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I2802874812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027323559","display_name":"Kishichiro Watanabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kishichiro Watanabe","raw_affiliation_strings":["Department of Clinical Laboratory, National Hospital of Kanazawa, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, National Hospital of Kanazawa, Kanazawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005375670","display_name":"Wilson M. S. Tsui","orcid":"https://orcid.org/0000-0001-6710-1576","observed_orcids":["https://orcid.org/0000-0001-6710-1576"]},"institutions":[{"id":"https://openalex.org/I2802874812","display_name":"Caritas Medical Centre","ror":"https://ror.org/01zqztb27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2802874812"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wilson Tsui","raw_affiliation_strings":["Department of Pathology, Caritas Medical Centre, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Caritas Medical Centre, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I2802874812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008003570","display_name":"Yasuni Nakanuma","orcid":"https://orcid.org/0000-0003-4117-6611","observed_orcids":["https://orcid.org/0000-0003-4117-6611"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I2802874812","display_name":"Caritas Medical Centre","ror":"https://ror.org/01zqztb27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2802874812"]}],"countries":["CN","JP"],"is_corresponding":true,"raw_author_name":"Yasuni Nakanuma","raw_affiliation_strings":["Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology (II), Kanazawa University School of Medicine, and Caritas Medical Centre, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I2802874812"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008003570"],"corresponding_institution_ids":["https://openalex.org/I10091056","https://openalex.org/I2802874812"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":2.1042,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.86516792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"30","issue":"4","first_page":"914","last_page":"919"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-telomerase","display_name":"human telomerase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/biliary-dysplasia","display_name":"biliary dysplasia","score":0.921999990940094},{"id":"https://openalex.org/keywords/preneoplastic-lesion","display_name":"preneoplastic lesion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hepatolithiasis","display_name":"hepatolithiasis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/human-telomerase-rna","display_name":"hTR","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.7549999952316284},{"id":"https://openalex.org/keywords/malignant-progression","display_name":"malignant progression","score":0.6880000233650208},{"id":"https://openalex.org/keywords/in-situ-hybridization","display_name":"in situ hybridization","score":0.6259999871253967},{"id":"https://openalex.org/keywords/biliary-epithelium","display_name":"biliary epithelium","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2777002071","wikidata":"https://www.wikidata.org/wiki/Q2933693","display_name":"Hepatolithiasis","level":4,"score":0.9168307781219482},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9102196097373962},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.7046672701835632},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.6733525991439819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6406514644622803},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6095404624938965},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5934594869613647},{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.5846561193466187},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.48425790667533875},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4568832516670227},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43984532356262207},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4355849623680115},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.4165400564670563},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4071888327598572},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3559027910232544},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2420157790184021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24192041158676147},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.15591716766357422},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13687440752983093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001660","descriptor_name":"Biliary Tract Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001660","descriptor_name":"Biliary Tract Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020347","descriptor_name":"Lithiasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020347","descriptor_name":"Lithiasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.510300419","doi":"https://doi.org/10.1002/hep.510300419","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.510300419","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510300419","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:10498642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10498642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/hep.510300419","doi":"https://doi.org/10.1002/hep.510300419","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.510300419","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510300419","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000853441.pdf","grobid_xml":"https://content.openalex.org/works/W2000853441.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W140652232","https://openalex.org/W1543500873","https://openalex.org/W1600373583","https://openalex.org/W1613006671","https://openalex.org/W1996867153","https://openalex.org/W2015037479","https://openalex.org/W2020675144","https://openalex.org/W2026382594","https://openalex.org/W2026856852","https://openalex.org/W2035499819","https://openalex.org/W2058197513","https://openalex.org/W2063271191","https://openalex.org/W2069752935","https://openalex.org/W2077034954","https://openalex.org/W2081327669","https://openalex.org/W2082653439","https://openalex.org/W2083195935","https://openalex.org/W2090083872","https://openalex.org/W2093419093","https://openalex.org/W2108213664","https://openalex.org/W2126224474","https://openalex.org/W2134812217","https://openalex.org/W2148805136","https://openalex.org/W2169455407","https://openalex.org/W2936739488"],"related_works":["https://openalex.org/W2006274600","https://openalex.org/W2154224729","https://openalex.org/W2033859358","https://openalex.org/W2358918325","https://openalex.org/W2370572793","https://openalex.org/W2387237095","https://openalex.org/W1992733063","https://openalex.org/W2004750837","https://openalex.org/W2033741319","https://openalex.org/W1985718071"],"abstract_inverted_index":{"Human":[0,17],"telomerase,":[1],"an":[2,44],"enzyme":[3],"associated":[4,68],"with":[5,69,102],"cellular":[6,230],"immortality":[7],"and":[8,25,36,52,76,104,129,146,150,171,209,226,238],"tumorigenesis,":[9],"is":[10,83,241],"expressed":[11],"by":[12],"most":[13],"malignant":[14,246],"tumor":[15],"cells.":[16,136],"telomerase":[18,22,26,220],"consists":[19],"of":[20,30,50,60,65,73,89,107,110,124,144,148,169,223,248],"human":[21],"RNA":[23],"(hTR)":[24],"protein":[27,40],"components.":[28],"One":[29],"the":[31,94,167,184,195,245],"latter":[32],"has":[33,232],"been":[34],"cloned":[35],"was":[37,55,91,116,138,155,189],"termed":[38],"telomerase-associated":[39],"1":[41,106],"(TP1).":[42],"Using":[43],"in":[45,57,93,97,105,134,166,183,194,203,207,235,244],"situ":[46],"hybridization":[47],"method,":[48],"expression":[49,147],"hTR":[51,128,149],"TP1":[53,130,151],"mRNA":[54,131],"surveyed":[56],"20":[58,125],"cases":[59,72,101,109],"intrahepatic":[61],"cholangiocarcinoma":[62],"(ICC)":[63],"(5":[64],"them":[66],"were":[67,132,163,180,200],"hepatolithiasis),":[70],"5":[71,99,108],"hepatolithiasis":[74,103,111,208],"alone":[75],"6":[77],"normal":[78,210],"livers.":[79,211],"Biliary":[80,153],"dysplasia,":[81],"which":[82],"suspected":[84],"as":[85,118],"a":[86],"preneoplastic":[87],"lesion":[88,240],"ICC,":[90],"found":[92],"biliary":[95,205,236],"tree":[96],"all":[98,217],"ICC":[100,126,145,218],"alone.":[112],"Normal":[113],"colonic":[114],"mucosa":[115],"used":[117],"positive":[119,157],"control.":[120],"In":[121],"17":[122],"(85%)":[123],"cases,":[127],"detected":[133,182,202],"carcinoma":[135,170],"There":[137],"no":[139],"correlation":[140],"between":[141],"histological":[142,224],"subtype":[143,225],"mRNA.":[152],"dysplasia":[154,237],"also":[156],"for":[158],"both":[159],"RNA.":[160],"These":[161,198],"signals":[162,179,199],"mainly":[164],"located":[165],"cytoplasm":[168],"dysplastic":[172,196],"cells,":[173],"especially":[174],"around":[175],"their":[176,187],"nuclei.":[177],"The":[178],"homogeneously":[181],"carcinoma,":[185],"while":[186],"distribution":[188],"more":[190,227],"or":[191],"less":[192],"heterogeneous":[193],"foci.":[197],"not":[201],"nondysplastic":[204],"epithelia":[206],"It":[212],"seems":[213],"likely":[214],"that":[215,229],"almost":[216],"acquired":[219],"activities":[221],"irrespective":[222],"importantly":[228],"immortalization":[231],"already":[233,242],"occurred":[234],"this":[239],"involved":[243],"progression":[247],"ICC.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
