{"id":"https://openalex.org/W2000853431","doi":"https://doi.org/10.1038/nrn2593","title":"Plasma membrane expansion: a neuron's Herculean task","display_name":"Plasma membrane expansion: a neuron's Herculean task","publication_year":2009,"publication_date":"2009-03-04","ids":{"openalex":"https://openalex.org/W2000853431","doi":"https://doi.org/10.1038/nrn2593","mag":"2000853431","pmid":"https://pubmed.ncbi.nlm.nih.gov/19259102"},"language":"en","primary_location":{"id":"doi:10.1038/nrn2593","doi":"https://doi.org/10.1038/nrn2593","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn2593","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108497289","display_name":"Karl H. Pfenninger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karl H. Pfenninger","raw_affiliation_strings":["Anschutz Medical Campus, Pediatrics and IDDRC, University of Colorado-Denver, Aurora, CO 80045, USA. Karl.Pfenninger@UCDenver.edu","University of Colorado Denver, Anschutz Medical Campus, Pediatrics and IDDRC, RC-1 North, Room 4130, PO Box 6511, Mail Stop 8313, Aurora, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anschutz Medical Campus, Pediatrics and IDDRC, University of Colorado-Denver, Aurora, CO 80045, USA. Karl.Pfenninger@UCDenver.edu","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado Denver, Anschutz Medical Campus, Pediatrics and IDDRC, RC-1 North, Room 4130, PO Box 6511, Mail Stop 8313, Aurora, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108497289"],"corresponding_institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":1.2369,"has_fulltext":false,"cited_by_count":268,"citation_normalized_percentile":{"value":0.77606178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"10","issue":"4","first_page":"251","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axon-and-dendrite-development","display_name":"axon and dendrite development","score":0.7120000123977661},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.7940000295639038},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/synaptic-vesicle-release","display_name":"synaptic vesicle release","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neuronal-regeneration","display_name":"neuronal regeneration","score":0.871999979019165},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.8151496052742004},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6979128122329712},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.6139169335365295},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5557097792625427},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5382843017578125},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5306118130683899},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.5254506468772888},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.4951459467411041},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4698559045791626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41618338227272034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37919944524765015},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3345875144004822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1448747217655182},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrn2593","doi":"https://doi.org/10.1038/nrn2593","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn2593","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},{"id":"pmid:19259102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19259102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W67277671","https://openalex.org/W274985342","https://openalex.org/W636302837","https://openalex.org/W1572968198","https://openalex.org/W1578401518","https://openalex.org/W1594060168","https://openalex.org/W1607993356","https://openalex.org/W1626886456","https://openalex.org/W1813819678","https://openalex.org/W1895213472","https://openalex.org/W1963573377","https://openalex.org/W1963576095","https://openalex.org/W1965514530","https://openalex.org/W1969911860","https://openalex.org/W1970049494","https://openalex.org/W1971490447","https://openalex.org/W1971785531","https://openalex.org/W1973756588","https://openalex.org/W1985730580","https://openalex.org/W1986564479","https://openalex.org/W1990888591","https://openalex.org/W1990958605","https://openalex.org/W1991585392","https://openalex.org/W1995231501","https://openalex.org/W1996381116","https://openalex.org/W1997750064","https://openalex.org/W1997885983","https://openalex.org/W1998154241","https://openalex.org/W2004102471","https://openalex.org/W2007141251","https://openalex.org/W2012423618","https://openalex.org/W2013722978","https://openalex.org/W2013995451","https://openalex.org/W2014095197","https://openalex.org/W2017301071","https://openalex.org/W2019404987","https://openalex.org/W2019780382","https://openalex.org/W2021271933","https://openalex.org/W2023140943","https://openalex.org/W2024168811","https://openalex.org/W2025615154","https://openalex.org/W2026750744","https://openalex.org/W2026998769","https://openalex.org/W2030509272","https://openalex.org/W2033712349","https://openalex.org/W2034468530","https://openalex.org/W2035327540","https://openalex.org/W2037706507","https://openalex.org/W2038110344","https://openalex.org/W2039005185","https://openalex.org/W2040537631","https://openalex.org/W2040577472","https://openalex.org/W2041798988","https://openalex.org/W2043270630","https://openalex.org/W2043466785","https://openalex.org/W2043706080","https://openalex.org/W2048320127","https://openalex.org/W2048981207","https://openalex.org/W2049232195","https://openalex.org/W2049236630","https://openalex.org/W2049402484","https://openalex.org/W2049450589","https://openalex.org/W2051283908","https://openalex.org/W2052166953","https://openalex.org/W2055401750","https://openalex.org/W2057685812","https://openalex.org/W2058987162","https://openalex.org/W2062155626","https://openalex.org/W2063565555","https://openalex.org/W2064181097","https://openalex.org/W2065323140","https://openalex.org/W2066118258","https://openalex.org/W2067166571","https://openalex.org/W2067814945","https://openalex.org/W2071987259","https://openalex.org/W2074782193","https://openalex.org/W2075485544","https://openalex.org/W2075942647","https://openalex.org/W2076602024","https://openalex.org/W2076788536","https://openalex.org/W2077278497","https://openalex.org/W2078047436","https://openalex.org/W2087277008","https://openalex.org/W2087938584","https://openalex.org/W2091323369","https://openalex.org/W2092815470","https://openalex.org/W2095099413","https://openalex.org/W2098512086","https://openalex.org/W2099949096","https://openalex.org/W2100943227","https://openalex.org/W2102883851","https://openalex.org/W2106773196","https://openalex.org/W2107143290","https://openalex.org/W2110728570","https://openalex.org/W2113387491","https://openalex.org/W2117053415","https://openalex.org/W2117730654","https://openalex.org/W2118259872","https://openalex.org/W2121244225","https://openalex.org/W2121926054","https://openalex.org/W2124813164","https://openalex.org/W2125178516","https://openalex.org/W2125199559","https://openalex.org/W2129409834","https://openalex.org/W2129629076","https://openalex.org/W2133043314","https://openalex.org/W2135004571","https://openalex.org/W2136333299","https://openalex.org/W2138505246","https://openalex.org/W2142521845","https://openalex.org/W2143296243","https://openalex.org/W2147298213","https://openalex.org/W2148231248","https://openalex.org/W2148673800","https://openalex.org/W2152220855","https://openalex.org/W2155154752","https://openalex.org/W2155194216","https://openalex.org/W2157337659","https://openalex.org/W2158408960","https://openalex.org/W2158920923","https://openalex.org/W2159269805","https://openalex.org/W2165254456","https://openalex.org/W2169800968","https://openalex.org/W2170385301","https://openalex.org/W2273448686","https://openalex.org/W2287605586","https://openalex.org/W2441629306","https://openalex.org/W3135190686","https://openalex.org/W4210958643","https://openalex.org/W4211197456"],"related_works":["https://openalex.org/W1999685134","https://openalex.org/W2206678767","https://openalex.org/W2329186577","https://openalex.org/W7027692215","https://openalex.org/W1614562370","https://openalex.org/W3199505100","https://openalex.org/W2042328801","https://openalex.org/W2767171326","https://openalex.org/W2149398996","https://openalex.org/W2957589834"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}