{"id":"https://openalex.org/W2000838750","doi":"https://doi.org/10.2174/1381612054367508","title":"Secretory IgA Antibodies from Plants","display_name":"Secretory IgA Antibodies from Plants","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2000838750","doi":"https://doi.org/10.2174/1381612054367508","mag":"2000838750","pmid":"https://pubmed.ncbi.nlm.nih.gov/16026297"},"language":"en","primary_location":{"id":"doi:10.2174/1381612054367508","doi":"https://doi.org/10.2174/1381612054367508","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612054367508","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063083161","display_name":"Keith L. Wycoff","orcid":"https://orcid.org/0000-0002-5343-5329","observed_orcids":["https://orcid.org/0000-0002-5343-5329"]},"institutions":[{"id":"https://openalex.org/I4210115535","display_name":"Planet Biotechnology (United States)","ror":"https://ror.org/022weqt39","country_code":"US","type":"company","lineage":["https://openalex.org/I4210115535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Wycoff","raw_affiliation_strings":["Planet Biotechnology Inc., USA. kwycoff@planetbiotechnology.com","Planet Biotechnology Inc., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Planet Biotechnology Inc., USA. kwycoff@planetbiotechnology.com","institution_ids":["https://openalex.org/I4210115535"]},{"raw_affiliation_string":"Planet Biotechnology Inc., USA","institution_ids":["https://openalex.org/I4210115535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063083161"],"corresponding_institution_ids":["https://openalex.org/I4210115535"],"apc_list":null,"apc_paid":null,"fwci":1.857,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.80442351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"19","first_page":"2429","last_page":"2437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.9810000061988831},{"id":"https://openalex.org/keywords/plant-made-antibodies","display_name":"plant-made antibodies","score":0.8230000138282776},{"id":"https://openalex.org/keywords/genetically-modified-plants","display_name":"transgenic plants","score":0.9760000109672546},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7160000205039978},{"id":"https://openalex.org/keywords/transgenic-tobacco","display_name":"transgenic tobacco","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.7200000286102295},{"id":"https://openalex.org/keywords/oral-bacteria","display_name":"oral bacteria","score":0.3880000114440918},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.6389999985694885},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.7710000276565552},{"id":"https://openalex.org/keywords/antibody-purification","display_name":"antibody purification","score":0.3089999854564667},{"id":"https://openalex.org/keywords/oral-immunotherapy","display_name":"oral immunotherapy","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7956528067588806},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7350722551345825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5564805269241333},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5477149486541748},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5394092798233032},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.504852831363678},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4642404317855835},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4596535563468933},{"id":"https://openalex.org/C2909735910","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Secretory IgA","level":3,"score":0.41109681129455566},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3944307863712311},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.22014689445495605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11753806471824646}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007071","descriptor_name":"Immunoglobulin A, Secretory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007071","descriptor_name":"Immunoglobulin A, Secretory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007071","descriptor_name":"Immunoglobulin A, Secretory","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046549","descriptor_name":"Plantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D046549","descriptor_name":"Plantibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046549","descriptor_name":"Plantibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612054367508","doi":"https://doi.org/10.2174/1381612054367508","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612054367508","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:16026297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16026297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W12362773","https://openalex.org/W138524017","https://openalex.org/W986103285","https://openalex.org/W1484070401","https://openalex.org/W1508637059","https://openalex.org/W1522921961","https://openalex.org/W1544101325","https://openalex.org/W1579220807","https://openalex.org/W1762713345","https://openalex.org/W1814267858","https://openalex.org/W1878759688","https://openalex.org/W1970140017","https://openalex.org/W1971276098","https://openalex.org/W1971389550","https://openalex.org/W1973109814","https://openalex.org/W1973283944","https://openalex.org/W1984315509","https://openalex.org/W1987482324","https://openalex.org/W2001300456","https://openalex.org/W2006424848","https://openalex.org/W2008414196","https://openalex.org/W2008779574","https://openalex.org/W2010779212","https://openalex.org/W2012784177","https://openalex.org/W2016468868","https://openalex.org/W2018292977","https://openalex.org/W2022564159","https://openalex.org/W2029625075","https://openalex.org/W2029903813","https://openalex.org/W2030336958","https://openalex.org/W2033331583","https://openalex.org/W2035851443","https://openalex.org/W2036053465","https://openalex.org/W2038681957","https://openalex.org/W2047694403","https://openalex.org/W2051268263","https://openalex.org/W2055366778","https://openalex.org/W2055507506","https://openalex.org/W2056319576","https://openalex.org/W2063193862","https://openalex.org/W2070090382","https://openalex.org/W2075380738","https://openalex.org/W2079771584","https://openalex.org/W2081246522","https://openalex.org/W2083158154","https://openalex.org/W2087160060","https://openalex.org/W2089653069","https://openalex.org/W2090517304","https://openalex.org/W2095693304","https://openalex.org/W2099241605","https://openalex.org/W2099582347","https://openalex.org/W2101173895","https://openalex.org/W2103226260","https://openalex.org/W2105688062","https://openalex.org/W2106120253","https://openalex.org/W2107427705","https://openalex.org/W2108205511","https://openalex.org/W2109538314","https://openalex.org/W2109842052","https://openalex.org/W2112663684","https://openalex.org/W2132177439","https://openalex.org/W2134105537","https://openalex.org/W2138656992","https://openalex.org/W2138844338","https://openalex.org/W2141881513","https://openalex.org/W2142667284","https://openalex.org/W2157325299","https://openalex.org/W2162339585","https://openalex.org/W2163412067","https://openalex.org/W2163683004","https://openalex.org/W2165832011","https://openalex.org/W2170981394","https://openalex.org/W2172171422","https://openalex.org/W2406329826","https://openalex.org/W4313308980"],"related_works":["https://openalex.org/W4232650349","https://openalex.org/W2379658588","https://openalex.org/W2903022316","https://openalex.org/W2044173441","https://openalex.org/W2022564159","https://openalex.org/W2178536569","https://openalex.org/W2029625075","https://openalex.org/W2475597349","https://openalex.org/W2036053465","https://openalex.org/W2065930346"],"abstract_inverted_index":{"Secretory":[0],"IgA":[1],"(SIgA)":[2],"is":[3,63,115,125,151],"the":[4,15,45,59,71,93,133,145,155,165,182],"antibody":[5,139,159,191],"type":[6],"produced":[7],"in":[8,67,110,121,144,154,173],"both":[9,38],"mammals":[10],"and":[11,40,78,96,178,186],"birds":[12],"that":[13,64,135],"protects":[14],"body":[16],"from":[17],"infection":[18],"at":[19],"mucosal":[20],"surfaces.":[21],"While":[22],"monoclonal":[23,84,104],"IgG":[24],"antibodies,":[25],"particularly":[26],"those":[27],"against":[28],"tumor":[29],"antigens,":[30],"have":[31],"received":[32],"a":[33,111,116,194],"great":[34],"deal":[35],"of":[36,47,58,73,132,147,181,189],"attention,":[37],"scientific":[39],"commercial,":[41],"as":[42,193],"immunotherapeutic":[43],"agents,":[44],"potential":[46],"SIgA":[48,65,85,105,200],"antibodies":[49,201],"has":[50],"only":[51,103],"recently":[52],"begun":[53],"to":[54,106,127,130,141],"be":[55,107,161],"exploited.":[56],"Part":[57],"reason":[60],"for":[61,83,99,196],"this":[62,190],"production":[66,86],"vivo":[68],"normally":[69],"requires":[70],"cooperation":[72],"two":[74],"different":[75],"cell":[76,81],"types,":[77],"single":[79],"animal":[80],"systems":[82],"are":[87,91],"inefficient.":[88],"Transgenic":[89],"plants":[90],"currently":[92],"most":[94],"productive":[95],"economical":[97],"system":[98],"making":[100],"SIgA.":[101],"The":[102,158],"tested":[108],"therapeutically":[109],"human":[112,174],"clinical":[113],"trial":[114],"product":[117],"called":[118],"CaroRx,":[119],"made":[120],"transgenic":[122],"tobacco,":[123,148],"which":[124],"designed":[126],"block":[128],"adherence":[129],"teeth":[131],"bacteria":[134],"causes":[136],"cavities.":[137],"This":[138],"accumulates":[140],"high":[142],"levels":[143],"leaves":[146],"where":[149],"it":[150],"located":[152],"primarily":[153],"endoplasmic":[156],"reticulum.":[157],"can":[160],"efficiently":[162],"purified":[163],"using":[164],"affinity":[166],"reagent":[167],"protein":[168],"G.":[169],"Topical":[170],"oral":[171],"treatment":[172],"subjects":[175],"was":[176],"safe":[177],"effective.":[179],"Characterization":[180],"expression,":[183],"secretion,":[184],"purification":[185],"therapeutic":[187,199],"use":[188],"serves":[192],"model":[195],"additional":[197],"plant-made":[198],"under":[202],"development.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
