{"id":"https://openalex.org/W2000827315","doi":"https://doi.org/10.1097/gme.0b013e3180305299","title":"Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial","display_name":"Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial","publication_year":2007,"publication_date":"2007-04-26","ids":{"openalex":"https://openalex.org/W2000827315","doi":"https://doi.org/10.1097/gme.0b013e3180305299","mag":"2000827315","pmid":"https://pubmed.ncbi.nlm.nih.gov/17464237"},"language":"en","primary_location":{"id":"doi:10.1097/gme.0b013e3180305299","doi":"https://doi.org/10.1097/gme.0b013e3180305299","is_oa":false,"landing_page_url":"https://doi.org/10.1097/gme.0b013e3180305299","pdf_url":null,"source":{"id":"https://openalex.org/S95311925","display_name":"Menopause The Journal of The North American Menopause Society","issn_l":"1072-3714","issn":["1072-3714","1530-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jian Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107037","display_name":"The Nisshin OilliO Group (Japan)","ror":"https://ror.org/010k79j48","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210107037"]},{"id":"https://openalex.org/I4405286539","display_name":"National Institute of Health and Nutrition","ror":"https://ror.org/02ep4t909","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383","https://openalex.org/I4405286539"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jian Wu","raw_affiliation_strings":["Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan","Regulatory and Scientific Affairs, Research Laboratory, Nisshin OilliO Group, Yokosuka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286539"]},{"raw_affiliation_string":"Regulatory and Scientific Affairs, Research Laboratory, Nisshin OilliO Group, Yokosuka, Japan","institution_ids":["https://openalex.org/I4210107037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110698257","display_name":"Jun Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191055192","display_name":"Tokyo Kasei University","ror":"https://ror.org/05xbyzq55","country_code":"JP","type":"education","lineage":["https://openalex.org/I191055192"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Oka","raw_affiliation_strings":["Department of Nutrition, Tokyo Kasei University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Tokyo Kasei University, Tokyo, Japan","institution_ids":["https://openalex.org/I191055192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089265385","display_name":"Junko Ezaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286539","display_name":"National Institute of Health and Nutrition","ror":"https://ror.org/02ep4t909","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383","https://openalex.org/I4405286539"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Ezaki","raw_affiliation_strings":["Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067132360","display_name":"Takuya Ohtomo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286539","display_name":"National Institute of Health and Nutrition","ror":"https://ror.org/02ep4t909","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383","https://openalex.org/I4405286539"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Ohtomo","raw_affiliation_strings":["Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111642195","display_name":"Tomomi Ueno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114030911","display_name":"Otsuka (Japan)","ror":"https://ror.org/013k5y296","country_code":"JP","type":"company","lineage":["https://openalex.org/I114030911"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Ueno","raw_affiliation_strings":["Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co. Ltd., Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co. Ltd., Saga, Japan","institution_ids":["https://openalex.org/I114030911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047417500","display_name":"Shigeto Uchiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114030911","display_name":"Otsuka (Japan)","ror":"https://ror.org/013k5y296","country_code":"JP","type":"company","lineage":["https://openalex.org/I114030911"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Uchiyama","raw_affiliation_strings":["Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co. Ltd., Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co. Ltd., Saga, Japan","institution_ids":["https://openalex.org/I114030911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049248142","display_name":"Toshiya Toda","orcid":"https://orcid.org/0000-0002-7559-7302","observed_orcids":["https://orcid.org/0000-0002-7559-7302"]},"institutions":[{"id":"https://openalex.org/I4405265328","display_name":"Fujicco Co., Ltd. (Japan)","ror":"https://ror.org/04g0bs696","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265328"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiya Toda","raw_affiliation_strings":["Research and Development Department, Fujicco Co. Ltd., Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, Fujicco Co. Ltd., Kobe, Japan","institution_ids":["https://openalex.org/I4405265328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103279102","display_name":"Mariko Uehara","orcid":"https://orcid.org/0000-0003-0402-0968","observed_orcids":["https://orcid.org/0000-0003-0402-0968"]},"institutions":[{"id":"https://openalex.org/I127317711","display_name":"Tokyo University of Agriculture","ror":"https://ror.org/05crbcr45","country_code":"JP","type":"education","lineage":["https://openalex.org/I127317711"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Uehara","raw_affiliation_strings":["Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan","Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan","institution_ids":["https://openalex.org/I127317711"]},{"raw_affiliation_string":"Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan; and","institution_ids":["https://openalex.org/I127317711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079899787","display_name":"Yoshiko Ishimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286539","display_name":"National Institute of Health and Nutrition","ror":"https://ror.org/02ep4t909","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383","https://openalex.org/I4405286539"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiko Ishimi","raw_affiliation_strings":["Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5079899787"],"corresponding_institution_ids":["https://openalex.org/I4405286539"],"apc_list":null,"apc_paid":null,"fwci":8.2934,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.98055478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"5","first_page":"866","last_page":"874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/equol","display_name":"equol","score":0.9869999885559082},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.8899999856948853},{"id":"https://openalex.org/keywords/daidzein","display_name":"daidzein","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8299999833106995},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.9490000009536743},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bone-loss-prevention","display_name":"bone loss prevention","score":0.6700000166893005},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.6190000176429749},{"id":"https://openalex.org/keywords/japanese-women","display_name":"Japanese women","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2781262405","wikidata":"https://www.wikidata.org/wiki/Q5384747","display_name":"Equol","level":4,"score":0.9783085584640503},{"id":"https://openalex.org/C2780955279","wikidata":"https://www.wikidata.org/wiki/Q408732","display_name":"Daidzein","level":3,"score":0.8541549444198608},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.7981452941894531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6997178792953491},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.5619971752166748},{"id":"https://openalex.org/C2910376424","wikidata":"https://www.wikidata.org/wiki/Q11006","display_name":"SOY ISOFLAVONES","level":3,"score":0.5449444651603699},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.5346412062644958},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4724217653274536},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4721885919570923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4657460153102875},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.4404549300670624},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.39907246828079224},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3382863402366638},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.30695009231567383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15082335472106934},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048789","descriptor_name":"Phytoestrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D048789","descriptor_name":"Phytoestrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060754","descriptor_name":"Equol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/gme.0b013e3180305299","doi":"https://doi.org/10.1097/gme.0b013e3180305299","is_oa":false,"landing_page_url":"https://doi.org/10.1097/gme.0b013e3180305299","pdf_url":null,"source":{"id":"https://openalex.org/S95311925","display_name":"Menopause The Journal of The North American Menopause Society","issn_l":"1072-3714","issn":["1072-3714","1530-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause","raw_type":"journal-article"},{"id":"pmid:17464237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17464237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause (New York, N.Y.)","raw_type":"Controlled Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.6875,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1849840946","https://openalex.org/W1901011363","https://openalex.org/W1969438573","https://openalex.org/W1997836645","https://openalex.org/W1999785937","https://openalex.org/W2005097850","https://openalex.org/W2005713074","https://openalex.org/W2017587984","https://openalex.org/W2019772604","https://openalex.org/W2021485462","https://openalex.org/W2026727054","https://openalex.org/W2033716528","https://openalex.org/W2039441471","https://openalex.org/W2040564355","https://openalex.org/W2046461292","https://openalex.org/W2053602264","https://openalex.org/W2059166442","https://openalex.org/W2068342497","https://openalex.org/W2070105273","https://openalex.org/W2089581332","https://openalex.org/W2089759622","https://openalex.org/W2102549077","https://openalex.org/W2104881987","https://openalex.org/W2105327564","https://openalex.org/W2114379216","https://openalex.org/W2118282380","https://openalex.org/W2120514773","https://openalex.org/W2124683343","https://openalex.org/W2127355714","https://openalex.org/W2127449230","https://openalex.org/W2131651024","https://openalex.org/W2135780072","https://openalex.org/W2139009678","https://openalex.org/W2140590679","https://openalex.org/W2149332512","https://openalex.org/W2157674770","https://openalex.org/W2159557075","https://openalex.org/W2168429805","https://openalex.org/W2168937933","https://openalex.org/W2169790062","https://openalex.org/W2189293589","https://openalex.org/W2239800878","https://openalex.org/W2287402019","https://openalex.org/W4211019127"],"related_works":["https://openalex.org/W2066814160","https://openalex.org/W2188644435","https://openalex.org/W2053324886","https://openalex.org/W180119126","https://openalex.org/W2109128236","https://openalex.org/W2036017458","https://openalex.org/W2108965120","https://openalex.org/W2033716528","https://openalex.org/W2004670485","https://openalex.org/W2321445417"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Equol":[1],"is":[2,11],"more":[3],"biologically":[4],"active":[5],"than":[6],"its":[7],"precursor":[8],"daidzein,":[9],"which":[10],"the":[12,23,34,48,75,115,120,125,131,134,137,141,146,158,167,177,184,190,196,200,207,220,226,234],"principal":[13],"isoflavone":[14,37,78,82,96,116,135,191],"found":[15],"in":[16,22,33,98,124,130,140,157,166,189,199,206,210,225,245],"soybean.":[17],"There":[18],"are":[19,58],"interindividual":[20],"differences":[21,32,180],"ability":[24],"to":[25,31,45,60,73,195],"produce":[26],"equol;":[27],"these":[28,169],"may":[29],"lead":[30],"effects":[35,49,76,236],"of":[36,50,77,81,86,145,237],"intervention":[38,117],"on":[39,53,88,107,239,250],"human":[40],"health.":[41],"This":[42],"study":[43],"aimed":[44],"investigate":[46],"whether":[47],"soy":[51],"isoflavones":[52,238],"bone":[54,89,142,211,240],"and":[55,94,149,154,161,163,187,214,223,242],"fat":[56,92,201,215,243],"mass":[57,216],"related":[59],"an":[61,251],"individual's":[62,252],"equol":[63,122,126,159,185,221],"status.":[64],"DESIGN:":[65],"We":[66],"performed":[67],"a":[68],"1-year":[69],"double-blind,":[70],"randomized":[71],"trial":[72],"compare":[74],"(75":[79],"mg":[80],"conjugates/day)":[83],"with":[84,193],"those":[85],"placebo":[87,227],"mineral":[90,143,212],"density,":[91],"mass,":[93],"serum":[95,121],"concentrations":[97],"early":[99,246],"postmenopausal":[100,247],"Japanese":[101],"women":[102,248],"who":[103],"were":[104,152,171,181],"classified":[105],"based":[106],"their":[108],"equol-producer":[109],"phenotype.":[110],"RESULTS:":[111],"After":[112],"1":[113],"year,":[114],"significantly":[118,172],"increased":[119],"concentration":[123],"producers":[127,160,186,222],"but":[128],"not":[129],"nonproducers.":[132],"In":[133],"group,":[136],"annualized":[138,197,208],"changes":[139,198,209],"density":[144,213],"total":[147],"hip":[148],"intertrochanteric":[150],"regions":[151],"-0.46%":[153],"-0.04%,":[155],"respectively,":[156,165],"-2.28%":[162],"-2.61%,":[164],"nonproducers;":[168],"values":[170],"different":[173],"(P<0.05":[174],"for":[175],"both":[176],"regions).":[178],"Significant":[179],"observed":[182,218],"between":[183,219],"nonproducers":[188,224],"group":[192],"regard":[194],"mass.":[202],"No":[203],"significant":[204],"difference":[205],"was":[217],"group.":[228],"CONCLUSIONS:":[229],"Our":[230],"data":[231],"suggest":[232],"that":[233],"preventive":[235],"loss":[241],"accumulation":[244],"depend":[249],"equol-producing":[253],"capacity.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}