{"id":"https://openalex.org/W2000823981","doi":"https://doi.org/10.1177/00220345960750031101","title":"A Regulatory Role in Mammalian Salivary Glands for 5-Hydroxytryptamine Receptors Coupled to Increased Cyclic AMP Production","display_name":"A Regulatory Role in Mammalian Salivary Glands for 5-Hydroxytryptamine Receptors Coupled to Increased Cyclic AMP Production","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2000823981","doi":"https://doi.org/10.1177/00220345960750031101","mag":"2000823981","pmid":"https://pubmed.ncbi.nlm.nih.gov/8675805"},"language":"en","primary_location":{"id":"doi:10.1177/00220345960750031101","doi":"https://doi.org/10.1177/00220345960750031101","is_oa":false,"landing_page_url":"https://doi.org/10.1177/00220345960750031101","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103577553","display_name":"John T. Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.T. Turner","raw_affiliation_strings":["Department of Pharmacology, M561 Health Sciences Center, University of Missouri-Columbia, Columbia, Missouri 65212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, M561 Health Sciences Center, University of Missouri-Columbia, Columbia, Missouri 65212, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073321102","display_name":"Daniel M. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.M. Sullivan","raw_affiliation_strings":["National Eye Institute, Building 10 Room 10B17, 9000 Rockville Pike, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, Building 10 Room 10B17, 9000 Rockville Pike, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014670369","display_name":"Ilsa I. Rovira","orcid":"https://orcid.org/0000-0002-0934-9378","observed_orcids":["https://orcid.org/0000-0002-0934-9378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Rovira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077548793","display_name":"Jean M. Camden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. Camden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.8992,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.74114544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"75","issue":"3","first_page":"935","last_page":"941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.875},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.984000027179718},{"id":"https://openalex.org/keywords/submandibular-gland","display_name":"submandibular gland","score":0.9940000176429749},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8500000238418579},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/salivary-flow","display_name":"salivary flow","score":0.7200000286102295},{"id":"https://openalex.org/keywords/salivary-protein-secretion","display_name":"salivary protein secretion","score":0.7730000019073486},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.878000020980835},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.6600000262260437},{"id":"https://openalex.org/keywords/sublingual-gland","display_name":"sublingual gland","score":0.8069999814033508},{"id":"https://openalex.org/keywords/parotid-gland","display_name":"parotid gland","score":0.9449999928474426},{"id":"https://openalex.org/keywords/opossum","display_name":"Didelphidae","score":0.7599999904632568},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2780266248","wikidata":"https://www.wikidata.org/wiki/Q579886","display_name":"Submandibular gland","level":2,"score":0.8591611385345459},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.8037077188491821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7989721894264221},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7495205402374268},{"id":"https://openalex.org/C2778937882","wikidata":"https://www.wikidata.org/wiki/Q134938","display_name":"Salivary gland","level":2,"score":0.6811385750770569},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6131756901741028},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5875234603881836},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.5587599277496338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5113853812217712},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4855618178844452},{"id":"https://openalex.org/C2776246950","wikidata":"https://www.wikidata.org/wiki/Q692200","display_name":"Sublingual gland","level":3,"score":0.48381370306015015},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.4272930920124054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4046689569950104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07879331707954407}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013363","descriptor_name":"Submandibular Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013363","descriptor_name":"Submandibular Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013363","descriptor_name":"Submandibular Gland","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/00220345960750031101","doi":"https://doi.org/10.1177/00220345960750031101","is_oa":false,"landing_page_url":"https://doi.org/10.1177/00220345960750031101","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},{"id":"pmid:8675805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8675805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of dental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5674273253","display_name":null,"funder_award_id":"DE 07389","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W83534692","https://openalex.org/W1775749144","https://openalex.org/W1846355032","https://openalex.org/W1958611107","https://openalex.org/W1968167017","https://openalex.org/W1975930176","https://openalex.org/W1980747493","https://openalex.org/W1981113743","https://openalex.org/W1988184946","https://openalex.org/W2015242960","https://openalex.org/W2027866310","https://openalex.org/W2048078487","https://openalex.org/W2142686003","https://openalex.org/W2153853866"],"related_works":["https://openalex.org/W2050212603","https://openalex.org/W2015242960","https://openalex.org/W2112311353","https://openalex.org/W2183593276","https://openalex.org/W2142686003","https://openalex.org/W1981666596","https://openalex.org/W2273072851","https://openalex.org/W2041372918","https://openalex.org/W2089665056","https://openalex.org/W2039151463"],"abstract_inverted_index":{"Although":[0],"a":[1,23,66,79,133,180,217],"functional":[2,153],"role":[3,24,80],"for":[4,25,65,81],"serotonin":[5],"(5-hydroxytryptamine,":[6],"5-HT)":[7],"has":[8],"been":[9,35],"defined":[10],"in":[11,27,45,69,83,124,136,174,196,220,234,239],"the":[12,28,61,76,107,120,125,137,163,214,226,241],"salivary":[13,32,222],"glands":[14,33,95,204,223],"of":[15,30,47,63,78,109,122,139,165,169,172,183,216,228,246],"some":[16],"lower":[17],"species,":[18],"relatively":[19],"few":[20],"data":[21],"supporting":[22],"5-HT":[26,67,82,105,131,166,184,193,218],"regulation":[29],"mammalian":[31,48,84,221],"have":[34],"presented.":[36],"Our":[37,211],"initial":[38],"results":[39],"from":[40,56,99,199],"polymerase":[41],"chain":[42],"reaction":[43],"studies":[44],"cells":[46,176,197],"submandibular":[49,85,94,203,236],"gland":[50,86,175],"origin":[51],"using":[52,90],"consensus":[53],"sequence":[54],"primers":[55],"G":[57],"protein-coupled":[58],"receptors":[59],"suggested":[60],"presence":[62,215],"mRNA":[64],"receptor":[68,219],"these":[70],"cells.":[71],"Based":[72],"on":[73,185],"this":[74,100],"observation,":[75],"question":[77],"function":[87],"was":[88,177],"re-addressed,":[89],"isolated,":[91],"perfused":[92,103],"rat":[93,206,235],"and":[96,118,201,205,208,243],"dispersed-cell":[97,129],"aggregates":[98],"gland.":[101],"In":[102,128,151],"glands,":[104],"decreased":[106],"rate":[108],"saliva":[110,126],"flow":[111],"initiated":[112],"by":[113,115],"acetylcholine":[114],"about":[116],"50%":[117],"increased":[119],"amount":[121],"protein":[123,244],"two-fold.":[127],"aggregates,":[130],"elicited":[132],"concentration-dependent":[134],"increase":[135],"accumulation":[138],"adenosine":[140],"3',5'":[141],"monophosphate":[142],"(cyclic":[143],"AMP;":[144],"EC50":[145],"=":[146],"660":[147],"+/-":[148],"110":[149],"nM).":[150],"addition,":[152],"studies,":[154],"as":[155,157],"well":[156],"radioligand":[158],"binding":[159],"experiments,":[160],"indicated":[161],"that":[162],"effects":[164],"are":[167],"independent":[168],"beta-adrenoceptors.":[170],"Accumulation":[171],"cAMP":[173],"consistent":[178],"with":[179],"direct":[181],"action":[182],"adenylyl":[186,229],"cyclase.":[187],"Similar":[188],"cyclic":[189],"AMP":[190],"responses":[191],"to":[192,225],"were":[194],"observed":[195],"isolated":[198],"mouse":[200],"opossum":[202],"sublingual":[207],"parotid":[209],"glands.":[210],"findings":[212],"suggest":[213],"coupled":[224],"stimulation":[227],"cyclase":[230],"and,":[231],"at":[232],"least":[233],"gland,":[237],"involved":[238],"modifying":[240],"volume":[242],"content":[245],"saliva.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
