{"id":"https://openalex.org/W2000822014","doi":"https://doi.org/10.1371/journal.pone.0081769","title":"WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation","display_name":"WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation","publication_year":2013,"publication_date":"2013-11-26","ids":{"openalex":"https://openalex.org/W2000822014","doi":"https://doi.org/10.1371/journal.pone.0081769","mag":"2000822014","pmid":"https://pubmed.ncbi.nlm.nih.gov/24303070"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0081769","doi":"https://doi.org/10.1371/journal.pone.0081769","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0081769","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081769&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081769&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009907218","display_name":"Sandrine L. Anne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandrine L. Anne","raw_affiliation_strings":["Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083867613","display_name":"Eve\u2010Ellen Govek","orcid":"https://orcid.org/0009-0001-1620-1101","observed_orcids":["https://orcid.org/0009-0001-1620-1101"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eve-Ellen Govek","raw_affiliation_strings":["Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005396404","display_name":"Olivier Ayrault","orcid":"https://orcid.org/0000-0002-7942-6674","observed_orcids":["https://orcid.org/0000-0002-7942-6674"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivier Ayrault","raw_affiliation_strings":["Department of Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051933628","display_name":"Jee Hae Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jee Hae Kim","raw_affiliation_strings":["Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101408713","display_name":"Xiaodong Zhu","orcid":"https://orcid.org/0000-0003-4345-5526","observed_orcids":["https://orcid.org/0000-0003-4345-5526"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Zhu","raw_affiliation_strings":["Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016578226","display_name":"David A. Murphy","orcid":"https://orcid.org/0000-0002-0715-3355","observed_orcids":["https://orcid.org/0000-0002-0715-3355"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Murphy","raw_affiliation_strings":["Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072827834","display_name":"Linda Van Aelst","orcid":"https://orcid.org/0000-0002-0870-012X","observed_orcids":["https://orcid.org/0000-0002-0870-012X"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Van Aelst","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America","Cold Spring Harbor Laboratory. Cold Spring Harbor, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory. Cold Spring Harbor, New York, United States of America","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018286109","display_name":"Martine F. Roussel","orcid":"https://orcid.org/0000-0002-1740-8139","observed_orcids":["https://orcid.org/0000-0002-1740-8139"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martine F. Roussel","raw_affiliation_strings":["Department of Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024200192","display_name":"Mary E. Hatten","orcid":"https://orcid.org/0000-0001-9059-660X","observed_orcids":["https://orcid.org/0000-0001-9059-660X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary E. Hatten","raw_affiliation_strings":["Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024200192"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.9577,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.91589745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"8","issue":"11","first_page":"e81769","last_page":"e81769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.459199994802475,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt3","display_name":"Wnt3","score":1.0},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/erk5","display_name":"ERK5","score":1.0},{"id":"https://openalex.org/keywords/non-canonical-wnt-signaling","display_name":"non-canonical Wnt signaling","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.9359999895095825},{"id":"https://openalex.org/keywords/atoh1","display_name":"Atoh1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cerebellar-development","display_name":"cerebellar development","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6872227787971497},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.6427669525146484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6412608623504639},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6147770881652832},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5510761737823486},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.4570922255516052},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42367318272590637},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41742128133773804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0658687949180603},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0081769","doi":"https://doi.org/10.1371/journal.pone.0081769","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0081769","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081769&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:24303070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24303070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:repository.cshl.edu:29671","doi":null,"is_oa":false,"landing_page_url":"https://repository.cshl.edu/id/eprint/29671/1/Van%20Aelst%20PLoS%20One%202013b.pdf","pdf_url":"https://repository.cshl.edu/id/eprint/29671/1/Van%20Aelst%20PLoS%20One%202013b.pdf","source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Paper"},{"id":"pmh:oai:europepmc.org:2833554","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3841149","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3841149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3841149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e227289a62dc48638ac98e5cc519c58c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e227289a62dc48638ac98e5cc519c58c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 11, p e81769 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/862257","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_WNT3_Inhibits_Cerebellar_Granule_Neuron_Progenitor_Proliferation_and_Medulloblastoma_Formation_via_MAPK_Activation_/862257","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0081769","doi":"https://doi.org/10.1371/journal.pone.0081769","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0081769","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081769&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1470995819","display_name":null,"funder_award_id":"P01CA-096832","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1471395058","display_name":null,"funder_award_id":"NS067289","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1851309420","display_name":null,"funder_award_id":"R01-MH082808","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2103451821","display_name":"DOCK7 Signaling in Neuronal Development","funder_award_id":"5r01mh082808-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2313405081","display_name":null,"funder_award_id":"R01 NS067289","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3208987442","display_name":null,"funder_award_id":"CA 096832","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G451888047","display_name":null,"funder_award_id":"MH082808","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4766096375","display_name":null,"funder_award_id":"CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6011756723","display_name":null,"funder_award_id":"NS-051778","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G689632563","display_name":null,"funder_award_id":"R01 NS051778","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000167938","display_name":null,"funder_award_id":"CA096832","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000884403","display_name":"NORMAL & NEOPLASTIC GROWTH IN THE BRAIN","funder_award_id":"5p01ca096832-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000822014.pdf","grobid_xml":"https://content.openalex.org/works/W2000822014.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W142203824","https://openalex.org/W1494249446","https://openalex.org/W1494857220","https://openalex.org/W1517007299","https://openalex.org/W1531753146","https://openalex.org/W1540812229","https://openalex.org/W1541821200","https://openalex.org/W1549831272","https://openalex.org/W1566737177","https://openalex.org/W1577577364","https://openalex.org/W1584833644","https://openalex.org/W1635607892","https://openalex.org/W1868780473","https://openalex.org/W1950889666","https://openalex.org/W1958993671","https://openalex.org/W1968379123","https://openalex.org/W1971412744","https://openalex.org/W1971876781","https://openalex.org/W1972207998","https://openalex.org/W1972538107","https://openalex.org/W1972727772","https://openalex.org/W1973526162","https://openalex.org/W1974374273","https://openalex.org/W1982482145","https://openalex.org/W1983341583","https://openalex.org/W1983833034","https://openalex.org/W1987248191","https://openalex.org/W1989194294","https://openalex.org/W1989918771","https://openalex.org/W1990549804","https://openalex.org/W1991771956","https://openalex.org/W1994794031","https://openalex.org/W1997889647","https://openalex.org/W2001181621","https://openalex.org/W2001193776","https://openalex.org/W2001324348","https://openalex.org/W2004191360","https://openalex.org/W2009925333","https://openalex.org/W2010261844","https://openalex.org/W2011129052","https://openalex.org/W2011334551","https://openalex.org/W2013891209","https://openalex.org/W2015222495","https://openalex.org/W2017668082","https://openalex.org/W2020101112","https://openalex.org/W2020603167","https://openalex.org/W2021754133","https://openalex.org/W2026668241","https://openalex.org/W2029549945","https://openalex.org/W2033291406","https://openalex.org/W2034188706","https://openalex.org/W2034595626","https://openalex.org/W2040448753","https://openalex.org/W2051877370","https://openalex.org/W2054702856","https://openalex.org/W2059917368","https://openalex.org/W2064153835","https://openalex.org/W2065169211","https://openalex.org/W2066672792","https://openalex.org/W2068430884","https://openalex.org/W2068856879","https://openalex.org/W2071141381","https://openalex.org/W2075082022","https://openalex.org/W2076014943","https://openalex.org/W2080372560","https://openalex.org/W2080732204","https://openalex.org/W2084352096","https://openalex.org/W2088394753","https://openalex.org/W2090542192","https://openalex.org/W2092880556","https://openalex.org/W2093691792","https://openalex.org/W2095647396","https://openalex.org/W2101127468","https://openalex.org/W2102366997","https://openalex.org/W2103694596","https://openalex.org/W2104789206","https://openalex.org/W2107101884","https://openalex.org/W2107511340","https://openalex.org/W2108964680","https://openalex.org/W2109120219","https://openalex.org/W2109232641","https://openalex.org/W2109281837","https://openalex.org/W2111197864","https://openalex.org/W2111334408","https://openalex.org/W2113786860","https://openalex.org/W2116509270","https://openalex.org/W2118746463","https://openalex.org/W2119284420","https://openalex.org/W2119657716","https://openalex.org/W2120452752","https://openalex.org/W2126735009","https://openalex.org/W2129730239","https://openalex.org/W2131008756","https://openalex.org/W2137279272","https://openalex.org/W2139787372","https://openalex.org/W2140266186","https://openalex.org/W2145941500","https://openalex.org/W2146017861","https://openalex.org/W2147539802","https://openalex.org/W2149380656","https://openalex.org/W2152769008","https://openalex.org/W2157454773","https://openalex.org/W2157636873","https://openalex.org/W2161566367","https://openalex.org/W2162037877","https://openalex.org/W2165376655","https://openalex.org/W2168420558","https://openalex.org/W2169346737","https://openalex.org/W2186720525","https://openalex.org/W2417217560","https://openalex.org/W4245062541","https://openalex.org/W4252975138"],"related_works":["https://openalex.org/W2409278910","https://openalex.org/W2377956979","https://openalex.org/W2019492885","https://openalex.org/W4388014052","https://openalex.org/W2004228152","https://openalex.org/W2465219495","https://openalex.org/W2365516742","https://openalex.org/W2360066506","https://openalex.org/W2367042309","https://openalex.org/W772272767"],"abstract_inverted_index":{"During":[0],"normal":[1],"cerebellar":[2,86],"development,":[3],"the":[4,20,25,59,111,117,138,148,163,187],"remarkable":[5],"expansion":[6],"of":[7,15,24,52,61,82,91,110,147,153,166,175,199,203],"granule":[8,16],"cell":[9],"progenitors":[10],"(GCPs)":[11],"generates":[12],"a":[13,30,54,79,127,157,183,191,197],"population":[14,23],"neurons":[17],"that":[18,36,49,64],"outnumbers":[19],"total":[21],"neuronal":[22],"cerebral":[26],"cortex,":[27],"and":[28,68,88,116,144,201],"provides":[29],"model":[31],"for":[32,194],"identifying":[33,47],"signaling":[34,62,130],"pathways":[35,48,63],"may":[37],"be":[38],"defective":[39],"in":[40,72,94,98,179],"medulloblastoma.":[41],"While":[42],"many":[43],"studies":[44],"focus":[45],"on":[46,168],"promote":[50],"growth":[51,93,125,178],"GCPs,":[53],"critical":[55],"unanswered":[56],"question":[57],"concerns":[58],"identification":[60],"block":[65],"mitogenic":[66],"stimulation":[67],"induce":[69],"early":[70,99],"steps":[71],"differentiation.":[73],"Here":[74],"we":[75],"identify":[76],"WNT3":[77,122,167,172,195],"as":[78,196],"novel":[80,192],"suppressor":[81],"GCP":[83,103,124,169],"proliferation":[84,104,174],"during":[85],"development":[87],"an":[89],"inhibitor":[90,161],"medulloblastoma":[92,176],"mice.":[95],"WNT3,":[96],"produced":[97],"postnatal":[100],"cerebellum,":[101],"inhibits":[102,173],"by":[105,182],"down-regulating":[106],"pro-proliferative":[107],"target":[108],"genes":[109],"mitogen":[112],"Sonic":[113],"Hedgehog":[114],"(SHH)":[115],"bHLH":[118],"transcription":[119],"factor":[120],"Atoh1.":[121],"suppresses":[123],"through":[126],"non-canonical":[128],"Wnt":[129],"pathway,":[131],"activating":[132],"prototypic":[133],"mitogen-activated":[134],"protein":[135],"kinases":[136,141],"(MAPKs),":[137],"Ras-dependent":[139],"extracellular-signal-regulated":[140],"1/2":[142],"(ERK1/2)":[143],"ERK5,":[145],"instead":[146],"classical":[149],"\u03b2-catenin":[150],"pathway.":[151],"Inhibition":[152],"MAPK":[154,158],"activity":[155],"using":[156],"kinase":[159],"(MEK)":[160],"reversed":[162],"inhibitory":[164],"effect":[165],"proliferation.":[170],"Importantly,":[171],"tumor":[177],"mouse":[180],"models":[181],"similar":[184],"mechanism.":[185],"Thus,":[186],"present":[188],"study":[189],"suggests":[190],"role":[193],"regulator":[198],"neurogenesis":[200],"repressor":[202],"neural":[204],"tumors.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
