{"id":"https://openalex.org/W2000815418","doi":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","title":"A double\u2010blind placebo\u2010controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation","display_name":"A double\u2010blind placebo\u2010controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation","publication_year":2008,"publication_date":"2008-05-29","ids":{"openalex":"https://openalex.org/W2000815418","doi":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","mag":"2000815418","pmid":"https://pubmed.ncbi.nlm.nih.gov/18510696"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2222.2008.03020.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03020.x","source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03020.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030496904","display_name":"Peter Adler W\u00fcrtzen","orcid":"https://orcid.org/0000-0003-1551-2415","observed_orcids":["https://orcid.org/0000-0003-1551-2415"]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"P. A. W\u00fcrtzen","raw_affiliation_strings":["ALK-Abell\u00f3, H\u00f8rsholm, Denmark. paw@dk.alk-abello.com","ALK-Abell\u00f3, H\u00f8rsholm, DENMARK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALK-Abell\u00f3, H\u00f8rsholm, Denmark. paw@dk.alk-abello.com","institution_ids":["https://openalex.org/I4210127808"]},{"raw_affiliation_string":"ALK-Abell\u00f3, H\u00f8rsholm, DENMARK","institution_ids":["https://openalex.org/I4210127808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080317953","display_name":"Gitte Lund","orcid":"https://orcid.org/0000-0003-2221-7465","observed_orcids":["https://orcid.org/0000-0003-2221-7465"]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"G. Lund","raw_affiliation_strings":["ALK-Abello\u0301, H\u00f8rsholm, Denmark","ALK-Abell\u00f3, H\u00f8rsholm, DENMARK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALK-Abello\u0301, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]},{"raw_affiliation_string":"ALK-Abell\u00f3, H\u00f8rsholm, DENMARK","institution_ids":["https://openalex.org/I4210127808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004635365","display_name":"Kaare Lund","orcid":"https://orcid.org/0000-0002-3520-7744","observed_orcids":["https://orcid.org/0000-0002-3520-7744"]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"K. Lund","raw_affiliation_strings":["ALK-Abello\u0301, H\u00f8rsholm, Denmark","ALK-Abell\u00f3, H\u00f8rsholm, DENMARK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALK-Abello\u0301, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]},{"raw_affiliation_string":"ALK-Abell\u00f3, H\u00f8rsholm, DENMARK","institution_ids":["https://openalex.org/I4210127808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059260790","display_name":"Monica Arvidsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. Arvidsson","raw_affiliation_strings":["Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg, SWEDEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg, SWEDEN","institution_ids":["https://openalex.org/I2801112325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000562434","display_name":"S. Rak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S. Rak","raw_affiliation_strings":["Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg, SWEDEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg, SWEDEN","institution_ids":["https://openalex.org/I2801112325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074599602","display_name":"Hans Henrik Ipsen","orcid":"https://orcid.org/0000-0003-2996-1748","observed_orcids":["https://orcid.org/0000-0003-2996-1748"]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H. Ipsen","raw_affiliation_strings":["ALK-Abello\u0301, H\u00f8rsholm, Denmark","ALK-Abell\u00f3, H\u00f8rsholm, DENMARK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALK-Abello\u0301, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]},{"raw_affiliation_string":"ALK-Abell\u00f3, H\u00f8rsholm, DENMARK","institution_ids":["https://openalex.org/I4210127808"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030496904"],"corresponding_institution_ids":["https://openalex.org/I4210127808"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":3.2538,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.91404928,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"38","issue":"8","first_page":"1290","last_page":"1301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/birch-pollen-allergy","display_name":"birch pollen allergy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ige-binding-inhibition","display_name":"IgE binding inhibition","score":0.7919999957084656},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cd23","display_name":"CD23","score":0.972000002861023},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/basophil-activation","display_name":"basophil activation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/immunotherapy-monitoring","display_name":"immunotherapy monitoring","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.8490668535232544},{"id":"https://openalex.org/C34814297","wikidata":"https://www.wikidata.org/wiki/Q4845302","display_name":"CD23","level":4,"score":0.771779477596283},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7500755786895752},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.6845536231994629},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6704275012016296},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5425906181335449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5120204091072083},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4949466586112976},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.41532328724861145},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.41461390256881714},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19183415174484253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1400337815284729},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09330368041992188}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D029662","descriptor_name":"Betula","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2222.2008.03020.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03020.x","source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Allergy","raw_type":"journal-article"},{"id":"pmid:18510696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18510696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2222.2008.03020.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.03020.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03020.x","source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000815418.pdf","grobid_xml":"https://content.openalex.org/works/W2000815418.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1483030058","https://openalex.org/W1518596541","https://openalex.org/W1524200221","https://openalex.org/W1576438536","https://openalex.org/W1586328535","https://openalex.org/W1921048215","https://openalex.org/W1965422322","https://openalex.org/W1973454669","https://openalex.org/W1973688027","https://openalex.org/W1974829009","https://openalex.org/W1976602395","https://openalex.org/W1977448573","https://openalex.org/W1979432463","https://openalex.org/W1981591196","https://openalex.org/W1984062235","https://openalex.org/W1990702493","https://openalex.org/W1992730407","https://openalex.org/W2010998136","https://openalex.org/W2016175222","https://openalex.org/W2024323471","https://openalex.org/W2026657673","https://openalex.org/W2033232206","https://openalex.org/W2045200013","https://openalex.org/W2046894131","https://openalex.org/W2052063445","https://openalex.org/W2055861246","https://openalex.org/W2062344567","https://openalex.org/W2066172231","https://openalex.org/W2066505403","https://openalex.org/W2068471769","https://openalex.org/W2069362757","https://openalex.org/W2074191073","https://openalex.org/W2075056701","https://openalex.org/W2075875408","https://openalex.org/W2089197792","https://openalex.org/W2092696976","https://openalex.org/W2093238448","https://openalex.org/W2094533088","https://openalex.org/W2095201078","https://openalex.org/W2098913651","https://openalex.org/W2104772500","https://openalex.org/W2112556582","https://openalex.org/W2112571043","https://openalex.org/W2114954094","https://openalex.org/W2116583914","https://openalex.org/W2123733113","https://openalex.org/W2135087799","https://openalex.org/W2150187523","https://openalex.org/W2158860741","https://openalex.org/W2168433233","https://openalex.org/W2169664925","https://openalex.org/W2409827305","https://openalex.org/W2418771730","https://openalex.org/W4291170056"],"related_works":["https://openalex.org/W2091898977","https://openalex.org/W2169664925","https://openalex.org/W2123733113","https://openalex.org/W2166948011","https://openalex.org/W2891348398","https://openalex.org/W1989293106","https://openalex.org/W2000365788","https://openalex.org/W2023776280","https://openalex.org/W6944222737","https://openalex.org/W1992236923"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,51,68,161,250],"pathogenesis":[2],"of":[3,13,27,53,76,127,148,183,189,198,209,224,229,262,293],"IgE-mediated":[4],"allergic":[5],"disease":[6],"is":[7,57],"closely":[8],"related":[9],"to":[10,21,47,72,88,121,129,156,272,288,299],"the":[11,48,74,146,201,206,217,227,260,290],"production":[12,23],"T-helper":[14],"type":[15],"2":[16,181],"(Th2)":[17],"cytokines,":[18],"which":[19,153],"lead":[20],"IgE":[22,62,86,103,151,245,267],"pivotal":[24],"for":[25,106],"activation":[26,52,232],"mast":[28],"cells":[29,34,56,131],"and":[30,39,93,104,124,144,177,180,200,221,226,247,270],"basophils.":[31],"Proliferating":[32],"T":[33,230],"along":[35],"with":[36,143],"eosinophils":[37],"expanded":[38],"attracted":[40],"by":[41,60,111,135],"Th2":[42,55],"cytokines":[43],"are":[44],"major":[45],"contributors":[46],"late-phase":[49],"reaction.":[50],"these":[54,279],"strongly":[58],"enhanced":[59],"CD23-mediated":[61,94],"facilitated":[63],"allergen":[64,95,107,128],"presentation":[65],"(FAP).":[66],"OBJECTIVE:":[67],"present":[69,251],"study":[70,122,252],"aims":[71],"investigate":[73],"effect":[75,202,292],"specific":[77],"immunotherapy":[78,169],"(SIT)-induced":[79],"allergen-specific":[80],"non-IgE":[81,105],"antibodies":[82,264],"(blocking":[83],"antibodies)":[84],"on":[85],"binding":[87,108,126,246],"allergen,":[89],"histamine":[90],"release":[91],"(HR)":[92],"uptake":[96],"in":[97,243,259,283,301],"antigen-presenting":[98],"cells.":[99],"METHODS:":[100],"Competition":[101],"between":[102,216,222,241],"was":[109,133,154,193,203,212],"studied":[110,134],"Advia":[112],"Centaur":[113],"antibody":[114],"measurements,":[115,280],"passively":[116],"sensitized":[117],"basophils":[118],"were":[119,140,164,239],"used":[120,287],"HR":[123,269],"IgE-facilitated":[125],"B":[130],"(FAP)":[132],"flow":[136],"cytometry.":[137],"FAP":[138,219,271],"measurements":[139,220],"performed":[141],"both":[142],"without":[145],"addition":[147],"a":[149,213,273],"reference":[150],"serum,":[152],"included":[155],"obtain":[157],"optimal":[158],"complex":[159],"formation.":[160],"serum":[162,263],"samples":[163],"obtained":[165],"from":[166],"birch":[167],"pollen":[168],"(n=21)":[170,175],"or":[171,282],"placebo":[172],"control":[173],"patients":[174],"before":[176],"after":[178,195],"1":[179,196],"years":[182],"treatment.":[184,210],"RESULTS:":[185],"Statistically":[186],"significant":[187],"reduction":[188],"all":[190],"parameters":[191,303],"investigated":[192],"observed":[194],"year":[197,208],"treatment":[199],"maintained":[204],"during":[205],"second":[207],"There":[211],"clear":[214],"correlation":[215],"two":[218],"each":[223],"them":[225],"level":[228],"cell":[231],"reported":[233],"upon":[234],"previously.":[235],"Moreover,":[236],"strong":[237],"correlations":[238,298],"found":[240],"changes":[242,258,300],"FAP,":[244],"HR.":[248],"CONCLUSION:":[249],"clearly":[253],"demonstrates":[254],"that":[255,265,278],"SIT":[256],"induces":[257],"composition":[261],"inhibit":[266],"binding,":[268],"similar":[274],"extent.":[275],"This":[276],"suggests":[277],"individually":[281],"combination,":[284],"may":[285],"be":[286,306],"monitor":[289],"immunological":[291],"SIT,":[294],"even":[295],"though":[296],"direct":[297],"clinical":[302],"could":[304],"not":[305],"demonstrated.":[307]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}