{"id":"https://openalex.org/W2000809031","doi":"https://doi.org/10.1134/s0006350906040154","title":"The biophysical aspects of reconstructing a single cell by the methods of cell engineering","display_name":"The biophysical aspects of reconstructing a single cell by the methods of cell engineering","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2000809031","doi":"https://doi.org/10.1134/s0006350906040154","mag":"2000809031","pmid":"https://pubmed.ncbi.nlm.nih.gov/16909846"},"language":"ru","primary_location":{"id":"doi:10.1134/s0006350906040154","doi":"https://doi.org/10.1134/s0006350906040154","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006350906040154","pdf_url":null,"source":{"id":"https://openalex.org/S53701631","display_name":"BIOPHYSICS","issn_l":"0006-3509","issn":["0006-3509","1555-6654"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"V. A. Nikitin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210155801","display_name":"Institute of Cell Biophysics","ror":"https://ror.org/05gbnpz65","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210155801"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"V. A. Nikitin","raw_affiliation_strings":["Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia","Institute of Cell Biophysics Russian Academy of Sciences Pushchino Moscow Region Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"]},{"raw_affiliation_string":"Institute of Cell Biophysics Russian Academy of Sciences Pushchino Moscow Region Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113914867","display_name":"Eugenii E. Fesenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210155801","display_name":"Institute of Cell Biophysics","ror":"https://ror.org/05gbnpz65","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210155801"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. E. Fesenko","raw_affiliation_strings":["Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia","Institute of Cell Biophysics Russian Academy of Sciences Pushchino Moscow Region Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"]},{"raw_affiliation_string":"Institute of Cell Biophysics Russian Academy of Sciences Pushchino Moscow Region Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.12505646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"51","issue":"4","first_page":"615","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mammalian-cloning","display_name":"mammalian cloning","score":0.7099999785423279},{"id":"https://openalex.org/keywords/microsurgery","display_name":"microsurgery","score":0.6710000038146973},{"id":"https://openalex.org/keywords/microinjection","display_name":"microinjection","score":0.777999997138977},{"id":"https://openalex.org/keywords/negative-pressure","display_name":"negative pressure","score":0.6869999766349792},{"id":"https://openalex.org/keywords/embryo-fixation","display_name":"embryo fixation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/capillary-forces","display_name":"capillary forces","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dna-microinjection","display_name":"DNA microinjection","score":0.671999990940094},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.9269850254058838},{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.7444254159927368},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5256023406982422},{"id":"https://openalex.org/C194242075","wikidata":"https://www.wikidata.org/wiki/Q546776","display_name":"Body orifice","level":2,"score":0.483522891998291},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4497985541820526},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.41599711775779724},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39936479926109314},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39311790466308594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36932796239852905},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.361281156539917},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2958945035934448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2490328848361969},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2101517617702484},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12566760182380676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1037246584892273},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019976","descriptor_name":"Cloning, Organism","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D019976","descriptor_name":"Cloning, Organism","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1134/s0006350906040154","doi":"https://doi.org/10.1134/s0006350906040154","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006350906040154","pdf_url":null,"source":{"id":"https://openalex.org/S53701631","display_name":"BIOPHYSICS","issn_l":"0006-3509","issn":["0006-3509","1555-6654"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysics","raw_type":"journal-article"},{"id":"pmid:16909846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16909846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biofizika","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W8786479","https://openalex.org/W1487014009","https://openalex.org/W1498836585","https://openalex.org/W1619397995","https://openalex.org/W1857189837","https://openalex.org/W1963605859","https://openalex.org/W1971784938","https://openalex.org/W1979055428","https://openalex.org/W1980031981","https://openalex.org/W1980195184","https://openalex.org/W1987082597","https://openalex.org/W1991197305","https://openalex.org/W1991678801","https://openalex.org/W1992240131","https://openalex.org/W2026903856","https://openalex.org/W2056054456","https://openalex.org/W2056172876","https://openalex.org/W2058013682","https://openalex.org/W2058092842","https://openalex.org/W2061555550","https://openalex.org/W2073803229","https://openalex.org/W2078465062","https://openalex.org/W2079544699","https://openalex.org/W2094074801","https://openalex.org/W2107385641","https://openalex.org/W2118440037","https://openalex.org/W6777405020"],"related_works":["https://openalex.org/W2514152741","https://openalex.org/W1987082597","https://openalex.org/W2415983321","https://openalex.org/W2480899002","https://openalex.org/W1980195184","https://openalex.org/W1484530178","https://openalex.org/W4221017886","https://openalex.org/W4412569374","https://openalex.org/W3197089898","https://openalex.org/W1857189837"],"abstract_inverted_index":{"The":[0,30,119,178],"problems":[1],"of":[2,6,16,19,22,32,48,72,80,95,101,106,113,124,134,140,146,167,173,181,202],"a":[3,137,168,170],"low":[4],"efficiency":[5],"mammalian":[7],"cloning":[8],"are":[9],"discussed":[10],"with":[11,27,45,150,185],"emphasis":[12],"on":[13,63,77],"the":[14,17,37,46,49,56,70,78,85,93,99,110,114,122,128,153,160,165,183,196],"necessity":[15],"expertise":[18],"each":[20],"step":[21],"single":[23],"cell":[24,33,38,73,107,125,161],"reconstruction,":[25],"beginning":[26],"microsurgical":[28],"manipulations.":[29],"fact":[31],"content":[34,74],"leakage":[35],"when":[36],"is":[39,89,191],"held":[40],"during":[41],"microsurgery":[42],"or":[43],"microinjections":[44],"help":[47],"conventional":[50,154],"method":[51,105,120,180],"using":[52,109],"negative":[53,81],"pressure":[54,82],"in":[55,61,84,152,193,195],"holding":[57,86,115,129],"micropipette":[58,116,184],"was":[59,67,117,176],"demonstrated":[60],"experiments":[62],"murine":[64],"embryos.":[65],"It":[66],"shown":[68],"that":[69],"rate":[71],"efflux":[75],"depends":[76],"value":[79],"generated":[83],"micropipette,":[87],"and":[88,98],"directly":[90],"proportional":[91],"to":[92,158],"dimensions":[94],"its":[96],"orifice":[97],"duration":[100],"micromanipulations.":[102],"An":[103],"alternative":[104],"fixation":[108,145],"capillary":[111],"forces":[112],"proposed.":[118,177],"optimizes":[121],"process":[123],"fixation,":[126],"reducing":[127],"effort":[130],"by":[131,164,207],"two":[132],"orders":[133],"magnitude.":[135],"As":[136],"result,":[138],"92%":[139],"embryos":[141],"remain":[142],"viable":[143],"after":[144],"embryo,":[147],"as":[148],"compared":[149],"39%":[151],"technique.":[155],"In":[156],"order":[157],"diminish":[159],"damage":[162],"produced":[163],"tip":[166],"microinstrument,":[169],"new":[171],"technique":[172],"fabricating":[174],"micropipettes":[175],"improved":[179],"filling":[182],"viscous":[186],"liquids,":[187],"including":[188],"DNA,":[189],"which":[190],"described":[192],"details":[194],"paper,":[197],"enabled":[198],"constant":[199],"(non-stop)":[200],"microinjection":[201],"more":[203],"than":[204],"1000":[205],"cells":[206],"hand,":[208],"without":[209],"any":[210],"special":[211],"automatic":[212],"device.":[213]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
