{"id":"https://openalex.org/W2000807423","doi":"https://doi.org/10.1371/journal.pone.0108448","title":"Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand","display_name":"Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand","publication_year":2014,"publication_date":"2014-09-22","ids":{"openalex":"https://openalex.org/W2000807423","doi":"https://doi.org/10.1371/journal.pone.0108448","mag":"2000807423","pmid":"https://pubmed.ncbi.nlm.nih.gov/25244654","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4171541"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0108448","doi":"https://doi.org/10.1371/journal.pone.0108448","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0108448","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0108448&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0108448&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074622797","display_name":"Osamu Ichii","orcid":"https://orcid.org/0000-0002-6643-1554","observed_orcids":["https://orcid.org/0000-0002-6643-1554"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Osamu Ichii","raw_affiliation_strings":["Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I205349734","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069479898","display_name":"Saori Otsuka-Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saori Otsuka-Kanazawa","raw_affiliation_strings":["Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071271547","display_name":"Teppei Nakamura","orcid":"https://orcid.org/0000-0003-3204-0245","observed_orcids":["https://orcid.org/0000-0003-3204-0245"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210154224","display_name":"Japan Food Research Laboratories","ror":"https://ror.org/04bxn2127","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210154224"]},{"id":"https://openalex.org/I4405264188","display_name":"Chitose Laboratory Corp. (Japan)","ror":"https://ror.org/016zba674","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264188"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teppei Nakamura","raw_affiliation_strings":["Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan","Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan","Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4210154224","https://openalex.org/I4405264188"]},{"raw_affiliation_string":"Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan","institution_ids":["https://openalex.org/I4210154224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102194227","display_name":"Ueno Masaaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154224","display_name":"Japan Food Research Laboratories","ror":"https://ror.org/04bxn2127","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210154224"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Ueno","raw_affiliation_strings":["Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan","institution_ids":["https://openalex.org/I4210154224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008415687","display_name":"Yasuhiro Kon","orcid":"https://orcid.org/0000-0002-8859-6122","observed_orcids":["https://orcid.org/0000-0002-8859-6122","https://orcid.org/0000-0003-0224-6197"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Kon","raw_affiliation_strings":["Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652326","display_name":"Weiping Chen","orcid":"https://orcid.org/0000-0002-0459-0605","observed_orcids":["https://orcid.org/0000-0002-0459-0605"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiping Chen","raw_affiliation_strings":["Microarray Core Facility, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microarray Core Facility, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030215181","display_name":"Avi Z. Rosenberg","orcid":"https://orcid.org/0000-0003-2356-950X","observed_orcids":["https://orcid.org/0000-0003-2356-950X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avi Z. Rosenberg","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044494633","display_name":"Jeffrey B. Kopp","orcid":"https://orcid.org/0000-0001-9052-186X","observed_orcids":["https://orcid.org/0000-0001-9052-186X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey B. Kopp","raw_affiliation_strings":["Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5074622797"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I205349734","https://openalex.org/I4210090567"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.9448,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.93033226,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"9","first_page":"e108448","last_page":"e108448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indoxyl-sulfate","display_name":"indoxyl sulfate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/uremic-toxins","display_name":"uremic toxins","score":0.9139999747276306},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/podocyte-injury","display_name":"podocyte injury","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7570000290870667},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pro-inflammatory-phenotype","display_name":"pro-inflammatory phenotype","score":0.7279999852180481},{"id":"https://openalex.org/keywords/podocin","display_name":"podocin","score":0.7179999947547913},{"id":"https://openalex.org/keywords/synaptopodin","display_name":"synaptopodin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.7039999961853027},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.5450000166893005},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.8257254958152771},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6086876392364502},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.5558633208274841},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4519006609916687},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4222375452518463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38956084847450256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.370535671710968},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3306088149547577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31967222690582275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2663819193840027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1031082272529602},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.07606896758079529},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007200","descriptor_name":"Indican","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007200","descriptor_name":"Indican","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0108448","doi":"https://doi.org/10.1371/journal.pone.0108448","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0108448","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0108448&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3144491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4171541","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25244654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25244654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4171541","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4171541/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007174953","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/57665","pdf_url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/57665/journal.pone.0108448.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS one","raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:465f0bc0c1c44362aa4e0d61b435698b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/465f0bc0c1c44362aa4e0d61b435698b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 9, p e108448 (2014)","raw_type":"article"},{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/57665","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2115/57665","pdf_url":null,"source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1177820","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Podocyte_Injury_Caused_by_Indoxyl_Sulfate_a_Uremic_Toxin_and_Aryl_Hydrocarbon_Receptor_Ligand_/1177820","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0108448","doi":"https://doi.org/10.1371/journal.pone.0108448","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0108448","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0108448&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2554854169","display_name":"Development of next-generation biomarkers for chronic kidney disease: MicroRNAs in the urine of companion animals","funder_award_id":"24688033","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000807423.pdf","grobid_xml":"https://content.openalex.org/works/W2000807423.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1897802080","https://openalex.org/W1948823449","https://openalex.org/W1969007011","https://openalex.org/W1971266941","https://openalex.org/W1974726237","https://openalex.org/W1980827669","https://openalex.org/W1985159905","https://openalex.org/W1995605291","https://openalex.org/W1998657400","https://openalex.org/W1999621052","https://openalex.org/W2000481993","https://openalex.org/W2004522121","https://openalex.org/W2011479582","https://openalex.org/W2018509996","https://openalex.org/W2032874629","https://openalex.org/W2037581573","https://openalex.org/W2040937358","https://openalex.org/W2041026780","https://openalex.org/W2044544228","https://openalex.org/W2046573345","https://openalex.org/W2047561041","https://openalex.org/W2053357822","https://openalex.org/W2061045666","https://openalex.org/W2065672265","https://openalex.org/W2066585632","https://openalex.org/W2068574968","https://openalex.org/W2072094974","https://openalex.org/W2075450457","https://openalex.org/W2080597274","https://openalex.org/W2081660694","https://openalex.org/W2086659744","https://openalex.org/W2089727303","https://openalex.org/W2092844004","https://openalex.org/W2093121077","https://openalex.org/W2095328109","https://openalex.org/W2101827523","https://openalex.org/W2101858380","https://openalex.org/W2104906781","https://openalex.org/W2106974808","https://openalex.org/W2107394952","https://openalex.org/W2107474953","https://openalex.org/W2109083270","https://openalex.org/W2109088768","https://openalex.org/W2114211654","https://openalex.org/W2116253756","https://openalex.org/W2117951926","https://openalex.org/W2120918533","https://openalex.org/W2122231873","https://openalex.org/W2122483672","https://openalex.org/W2132468584","https://openalex.org/W2137496003","https://openalex.org/W2138329309","https://openalex.org/W2145073188","https://openalex.org/W2156708958","https://openalex.org/W2164934883","https://openalex.org/W2165302973","https://openalex.org/W2168450345","https://openalex.org/W2168987491","https://openalex.org/W2171220061","https://openalex.org/W2203122089","https://openalex.org/W2417437863","https://openalex.org/W4301069754"],"related_works":["https://openalex.org/W1938850638","https://openalex.org/W2416054795","https://openalex.org/W3016825299","https://openalex.org/W2762087939","https://openalex.org/W2756155367","https://openalex.org/W2982514595","https://openalex.org/W4415435368","https://openalex.org/W2085463779","https://openalex.org/W2117951926","https://openalex.org/W4239727677"],"abstract_inverted_index":{"Indoxyl":[0,59],"sulfate":[1,20,36,48,97,186,200,227,278],"is":[2],"a":[3,7,14,124,207],"uremic":[4],"toxin":[5],"and":[6,28,41,78,123,127,132,137,169,188,218,245,249,252,269],"ligand":[8],"of":[9,113,130,155,215,235,260,273],"the":[10,89,141,146],"aryl-hydrocarbon":[11],"receptor":[12],"(AhR),":[13],"transcriptional":[15],"regulator.":[16],"Elevated":[17],"serum":[18],"indoxyl":[19,35,47,96,114,147,185,199,226,277],"levels":[21,259],"may":[22],"contribute":[23],"to":[24,46,88,95,151,198,280],"progressive":[25,281],"kidney":[26],"disease":[27],"associated":[29],"vascular":[30,57],"disease.":[31],"We":[32,255],"asked":[33],"whether":[34],"injures":[37],"podocytes":[38,116,174,205],"in":[39,42,140,145],"vivo":[40],"vitro.":[43],"Mice":[44],"exposed":[45,94],"for":[49,98,201],"8":[50,111],"w":[51,112],"exhibited":[52,175,206],"prominent":[53],"tubulointerstitial":[54],"lesions":[55],"with":[56,62],"damage.":[58],"sulfate-exposed":[60,148],"mice":[61,71,93],"microalbuminuria":[63],"showed":[64,72,117],"ischemic":[65],"changes,":[66],"while":[67],"more":[68],"severely":[69],"affected":[70],"increased":[73,104,144,191,250,271],"mesangial":[74],"matrix,":[75],"segmental":[76],"solidification,":[77],"mesangiolysis.":[79],"In":[80,92,171,222],"normal":[81,267],"mouse":[82,204],"kidneys,":[83],"AhR":[84,108,138,176,261,275],"was":[85,143,159,190],"predominantly":[86],"localized":[87],"podocyte":[90,157,264,274],"nuclei.":[91],"2":[99,194],"h,":[100,203],"isolated":[101],"glomeruli":[102,149],"manifested":[103],"Cyp1a1":[105],"expression,":[106],"indicating":[107],"activation.":[109],"After":[110,196],"sulfate,":[115],"foot":[118],"process":[119],"effacement,":[120],"cytoplasmic":[121],"vacuoles,":[122],"focal":[125],"granular":[126],"wrinkled":[128],"pattern":[129],"podocin":[131],"synaptopodin":[133],"expression.":[134,254],"Furthermore,":[135],"vimentin":[136],"expression":[139,154,214,234],"glomerulus":[142],"compared":[150],"controls.":[152],"Glomerular":[153],"characteristic":[156],"mRNAs":[158],"decreased,":[160],"including":[161],"Actn4,":[162],"Cd2ap,":[163],"Myh9,":[164],"Nphs1,":[165],"Nphs2,":[166],"Podxl,":[167],"Synpo,":[168],"Wt1.":[170],"vitro,":[172],"immortalized-mouse":[173],"nuclear":[177],"translocation":[178],"beginning":[179],"30":[180],"min":[181],"after":[182],"1":[183],"mM":[184],"exposure,":[187],"there":[189],"phospho-Rac1/Cdc42":[192],"at":[193],"h.":[195],"exposure":[197],"24":[202],"pro-inflammatory":[208],"phenotype,":[209],"perturbed":[210],"actin":[211],"cytoskeleton,":[212],"decreased":[213,219,232],"podocyte-specific":[216,236],"genes,":[217],"cell":[220,230],"viability.":[221],"immortalized":[223],"human":[224],"podocytes,":[225],"treatment":[228],"caused":[229],"injury,":[231],"mRNA":[233],"proteins,":[237,244,248],"as":[238,240],"well":[239],"integrins,":[241],"collagens,":[242],"cytoskeletal":[243],"bone":[246],"morphogenetic":[247],"cytokine":[251],"chemokine":[253],"propose":[256],"that":[257,270],"basal":[258],"activity":[262],"regulate":[263],"function":[265],"under":[266],"conditions,":[268],"activation":[272],"by":[276],"contributes":[279],"glomerular":[282],"injury.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
