{"id":"https://openalex.org/W2000805551","doi":"https://doi.org/10.1586/17476348.1.2.255","title":"Proteomics of lung cell biology and pulmonary disease","display_name":"Proteomics of lung cell biology and pulmonary disease","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2000805551","doi":"https://doi.org/10.1586/17476348.1.2.255","mag":"2000805551","pmid":"https://pubmed.ncbi.nlm.nih.gov/20477189"},"language":"en","primary_location":{"id":"doi:10.1586/17476348.1.2.255","doi":"https://doi.org/10.1586/17476348.1.2.255","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17476348.1.2.255","pdf_url":null,"source":{"id":"https://openalex.org/S121778365","display_name":"Expert Review of Respiratory Medicine","issn_l":"1747-6348","issn":["1747-6348","1747-6356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Respiratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042298641","display_name":"Stewart J. Levine","orcid":"https://orcid.org/0000-0001-9313-9746","observed_orcids":["https://orcid.org/0000-0001-9313-9746"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stewart J Levine","raw_affiliation_strings":["National Institutes of Health, Pulmonary-Critical Care Medicine Branch, NHLBI, Building 10, Room 6D03, MSC 1590, Bethesda, MD 0892-1590, USA. levines@nhlbi.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Pulmonary-Critical Care Medicine Branch, NHLBI, Building 10, Room 6D03, MSC 1590, Bethesda, MD 0892-1590, USA. levines@nhlbi.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042298641"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":null,"apc_paid":null,"fwci":0.308,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50838076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"2","first_page":"255","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-proteome","display_name":"lung proteome","score":0.925000011920929},{"id":"https://openalex.org/keywords/lung-disease","display_name":"lung disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.7990000247955322},{"id":"https://openalex.org/keywords/low-abundance-protein-detection","display_name":"low-abundance protein detection","score":0.8130000233650208},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":1.0},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":1.0},{"id":"https://openalex.org/keywords/sarcoidosis","display_name":"sarcoidosis","score":1.0},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8199999928474426},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"nanotechnology","score":0.8330000042915344},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":1.0},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.972000002861023},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7111120223999023},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5833303928375244},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5668012499809265},{"id":"https://openalex.org/C2983914783","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Lung disease","level":3,"score":0.543701171875},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5227898955345154},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.4726772904396057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4070843458175659},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3456370234489441},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3367098569869995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24306857585906982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22100064158439636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08918380737304688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1586/17476348.1.2.255","doi":"https://doi.org/10.1586/17476348.1.2.255","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17476348.1.2.255","pdf_url":null,"source":{"id":"https://openalex.org/S121778365","display_name":"Expert Review of Respiratory Medicine","issn_l":"1747-6348","issn":["1747-6348","1747-6356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Respiratory Medicine","raw_type":"journal-article"},{"id":"pmid:20477189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20477189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of respiratory medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W1505550212","https://openalex.org/W1536912963","https://openalex.org/W1553889001","https://openalex.org/W1597678601","https://openalex.org/W1762620449","https://openalex.org/W1884509322","https://openalex.org/W1898218536","https://openalex.org/W1927692905","https://openalex.org/W1953681441","https://openalex.org/W1966077509","https://openalex.org/W1967225297","https://openalex.org/W1967661005","https://openalex.org/W1968696174","https://openalex.org/W1970759948","https://openalex.org/W1971798125","https://openalex.org/W1972289025","https://openalex.org/W1972395654","https://openalex.org/W1974328661","https://openalex.org/W1977316020","https://openalex.org/W1979744503","https://openalex.org/W1982267716","https://openalex.org/W1987164253","https://openalex.org/W1989058855","https://openalex.org/W1991989394","https://openalex.org/W1992895183","https://openalex.org/W1994559611","https://openalex.org/W1994966843","https://openalex.org/W1996092472","https://openalex.org/W1997481284","https://openalex.org/W1999751972","https://openalex.org/W2002642674","https://openalex.org/W2003615253","https://openalex.org/W2004486463","https://openalex.org/W2005380867","https://openalex.org/W2007547050","https://openalex.org/W2014464905","https://openalex.org/W2016957415","https://openalex.org/W2024078329","https://openalex.org/W2030205108","https://openalex.org/W2033692581","https://openalex.org/W2034038743","https://openalex.org/W2035530476","https://openalex.org/W2035793161","https://openalex.org/W2038088590","https://openalex.org/W2038543819","https://openalex.org/W2040860636","https://openalex.org/W2041297715","https://openalex.org/W2042354033","https://openalex.org/W2043113652","https://openalex.org/W2043444502","https://openalex.org/W2045189438","https://openalex.org/W2046052274","https://openalex.org/W2050456271","https://openalex.org/W2050682399","https://openalex.org/W2053213336","https://openalex.org/W2061417332","https://openalex.org/W2062656880","https://openalex.org/W2064106755","https://openalex.org/W2064314786","https://openalex.org/W2066381817","https://openalex.org/W2068669920","https://openalex.org/W2070616342","https://openalex.org/W2070983898","https://openalex.org/W2072705074","https://openalex.org/W2079000749","https://openalex.org/W2082518539","https://openalex.org/W2083260383","https://openalex.org/W2084186902","https://openalex.org/W2084809520","https://openalex.org/W2085101416","https://openalex.org/W2085314527","https://openalex.org/W2085705524","https://openalex.org/W2085827128","https://openalex.org/W2089081493","https://openalex.org/W2093347595","https://openalex.org/W2094229819","https://openalex.org/W2097162772","https://openalex.org/W2097189873","https://openalex.org/W2097862839","https://openalex.org/W2098296430","https://openalex.org/W2099317703","https://openalex.org/W2104178795","https://openalex.org/W2104676202","https://openalex.org/W2106837648","https://openalex.org/W2108269665","https://openalex.org/W2109689215","https://openalex.org/W2111768994","https://openalex.org/W2112076133","https://openalex.org/W2112299827","https://openalex.org/W2114322648","https://openalex.org/W2117693378","https://openalex.org/W2123822147","https://openalex.org/W2124133870","https://openalex.org/W2126010406","https://openalex.org/W2127230663","https://openalex.org/W2128036243","https://openalex.org/W2133826923","https://openalex.org/W2135125256","https://openalex.org/W2139574363","https://openalex.org/W2143418398","https://openalex.org/W2148138885","https://openalex.org/W2148411266","https://openalex.org/W2148957569","https://openalex.org/W2149279243","https://openalex.org/W2150114991","https://openalex.org/W2151695888","https://openalex.org/W2154282484","https://openalex.org/W2158973268","https://openalex.org/W2159680207","https://openalex.org/W2159997339","https://openalex.org/W2162919377","https://openalex.org/W2163344857","https://openalex.org/W2165460636","https://openalex.org/W2168909179","https://openalex.org/W2169383077","https://openalex.org/W2171825228","https://openalex.org/W2172116519","https://openalex.org/W2176854338","https://openalex.org/W2347879035","https://openalex.org/W4210241463","https://openalex.org/W4233751197"],"related_works":["https://openalex.org/W1025550441","https://openalex.org/W1983682031","https://openalex.org/W1989058855","https://openalex.org/W2148411266","https://openalex.org/W2810485841","https://openalex.org/W2962896543","https://openalex.org/W2069838626","https://openalex.org/W4399767876","https://openalex.org/W2012797180","https://openalex.org/W1991975049"],"abstract_inverted_index":{"Proteomics":[0],"has":[1,70],"the":[2,6,36,92,136,147],"goal":[3],"of":[4,10,38,94,97,117,125,138],"defining":[5],"complete":[7],"protein":[8,27],"complement":[9],"biological":[11,77],"systems,":[12],"which":[13],"can":[14,33,41],"then":[15],"be":[16,42],"analyzed":[17],"in":[18,75,100],"a":[19],"comparative":[20],"fashion":[21],"to":[22,44,57,141],"generate":[23],"informative":[24],"data":[25,145],"regarding":[26,146,165],"expression":[28],"and":[29,46,51,90,113,119,128,143,155,173],"function.":[30],"Proteomic":[31],"analyses":[32,84],"also":[34],"facilitate":[35,161],"discovery":[37,172],"biomarkers":[39],"that":[40],"used":[43],"diagnose":[45],"monitor":[47],"disease":[48,98,169],"severity,":[49],"activity":[50],"therapeutic":[52],"response,":[53],"as":[54,56,104,121,123],"well":[55,122],"identify":[58],"new":[59,95],"targets":[60],"for":[61,67],"drug":[62,174],"development.":[63,175],"A":[64],"major":[65],"challenge":[66],"proteomics,":[68],"however,":[69],"been":[71],"detecting":[72],"low-abundance":[73],"proteins":[74],"complex":[76],"fluids.":[78],"This":[79],"review":[80],"summarizes":[81],"how":[82],"proteomic":[83],"have":[85],"advanced":[86],"lung":[87,108,111,148,166],"cell":[88,167],"biology":[89],"facilitated":[91],"identification":[93],"mechanisms":[96],"pathogenesis":[99],"respiratory":[101],"disorders,":[102],"such":[103],"asthma,":[105],"cystic":[106],"fibrosis,":[107],"cancer,":[109],"acute":[110],"injury":[112],"sarcoidosis.":[114],"The":[115],"impact":[116],"nanotechnology":[118],"microfluidics,":[120],"studies":[124],"post-translational":[126],"modifications":[127],"protein-protein":[129],"interactions":[130],"(the":[131],"interactome),":[132],"are":[133],"considered.":[134],"Furthermore,":[135],"application":[137],"systems-biology":[139],"approaches":[140],"organize":[142],"analyze":[144],"proteome,":[149],"interactome,":[150],"genome,":[151],"transcriptome,":[152],"metabolome,":[153],"glycome":[154],"small":[156],"RNAome":[157],"(regulatory":[158],"RNAs),":[159],"should":[160],"future":[162],"conceptual":[163],"advances":[164],"biology,":[168],"pathogenesis,":[170],"biomarker":[171]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2016-06-24T00:00:00"}