{"id":"https://openalex.org/W2000800813","doi":"https://doi.org/10.1016/j.pog.2012.07.010","title":"Valor pron\u00f3stico de los receptores hormonales, receptor del factor de crecimiento epid\u00e9rmico humano, ciclinas D1 y D2, B-Cell Lymphoma2 y ciclooxigenasa-2 en pacientes j\u00f3venes con c\u00e1ncer de mama","display_name":"Valor pron\u00f3stico de los receptores hormonales, receptor del factor de crecimiento epid\u00e9rmico humano, ciclinas D1 y D2, B-Cell Lymphoma2 y ciclooxigenasa-2 en pacientes j\u00f3venes con c\u00e1ncer de mama","publication_year":2013,"publication_date":"2013-02-26","ids":{"openalex":"https://openalex.org/W2000800813","doi":"https://doi.org/10.1016/j.pog.2012.07.010","mag":"2000800813"},"language":"es","primary_location":{"id":"doi:10.1016/j.pog.2012.07.010","doi":"https://doi.org/10.1016/j.pog.2012.07.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pog.2012.07.010","pdf_url":null,"source":{"id":"https://openalex.org/S2898135453","display_name":"Progresos de Obstetricia y Ginecolog\u00eda","issn_l":"0304-5013","issn":["0304-5013","1578-1453"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315687","host_organization_name":"CIG Media Group","host_organization_lineage":["https://openalex.org/P4310315687"],"host_organization_lineage_names":["CIG Media Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progresos de Obstetricia y Ginecolog\u00eda","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010584728","display_name":"M. Rosario Noguero Meseguer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165837","display_name":"Hospital Universitario Infanta Cristina","ror":"https://ror.org/05txkk980","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165837"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. Rosario Noguero Meseguer","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210165837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076075688","display_name":"Laura Yago Lisbona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093872","display_name":"Hospital Universitario de Guadalajara","ror":"https://ror.org/00jkz9152","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210093872","https://openalex.org/I4210141158"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Yago Lisbona","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital Universitario de Guadalajara, Guadalajara, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital Universitario de Guadalajara, Guadalajara, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210093872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062770128","display_name":"Beatriz Segovia Bl\u00e1zquez","orcid":"https://orcid.org/0009-0008-2286-0059","observed_orcids":["https://orcid.org/0009-0008-2286-0059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beatriz Segovia Bl\u00e1zquez","raw_affiliation_strings":["Servicio de Anatom\u00eda Patol\u00f3gica, Hospital de \u00c1vila, \u00c1vila, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Anatom\u00eda Patol\u00f3gica, Hospital de \u00c1vila, \u00c1vila, Espa\u00f1a","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085451097","display_name":"Mirta Diez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165837","display_name":"Hospital Universitario Infanta Cristina","ror":"https://ror.org/05txkk980","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165837"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Mar Mu\u00f1oz D\u00edez","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210165837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042756588","display_name":"Silvia Mart\u00edn Guti\u00e9rrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165837","display_name":"Hospital Universitario Infanta Cristina","ror":"https://ror.org/05txkk980","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165837"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Mart\u00edn Guti\u00e9rrez","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210165837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060177969","display_name":"Ruth Carpintero Franco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165837","display_name":"Hospital Universitario Infanta Cristina","ror":"https://ror.org/05txkk980","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165837"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ruth Carpintero Franco","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital Universitario Infanta Cristina, Parla, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210165837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103563617","display_name":"Blanca Sancho P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Blanca Sancho P\u00e9rez","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108570208","display_name":"Marta Gallego \u00c1lvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Gallego Alvarez","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110415949","display_name":"M Ferrandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Consuelo Sanz Ferr\u00e1ndez","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029687231","display_name":"Jose Luis Mendiz\u00e1bal Ur\u00edzar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106436","display_name":"Hospital Txagorritxu","ror":"https://ror.org/01pzjt917","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210106436"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Luis Mendiz\u00e1bal Ur\u00edzar","raw_affiliation_strings":["Servicio de Ginecolog\u00eda, Hospital de Txagorritxu, Vitoria-Gasteiz, \u00c1lava, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda, Hospital de Txagorritxu, Vitoria-Gasteiz, \u00c1lava, Espa\u00f1a","institution_ids":["https://openalex.org/I4210106436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010584728"],"corresponding_institution_ids":["https://openalex.org/I4210165837"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08798809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"5","first_page":"242","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.7879999876022339},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":1.0},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.453000009059906},{"id":"https://openalex.org/keywords/tissue-arrays","display_name":"tissue arrays","score":0.8360000252723694},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.3619999885559082},{"id":"https://openalex.org/keywords/hormone-receptor-negative-breast-cancer","display_name":"hormone receptor-negative breast cancer","score":0.5460000038146973},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/luminal-a-subtype","display_name":"luminal A","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.748184323310852},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6099206209182739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.pog.2012.07.010","doi":"https://doi.org/10.1016/j.pog.2012.07.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pog.2012.07.010","pdf_url":null,"source":{"id":"https://openalex.org/S2898135453","display_name":"Progresos de Obstetricia y Ginecolog\u00eda","issn_l":"0304-5013","issn":["0304-5013","1578-1453"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315687","host_organization_name":"CIG Media Group","host_organization_lineage":["https://openalex.org/P4310315687"],"host_organization_lineage_names":["CIG Media Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progresos de Obstetricia y Ginecolog\u00eda","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1505543598","https://openalex.org/W1890740011","https://openalex.org/W1930728042","https://openalex.org/W1973061751","https://openalex.org/W1976098555","https://openalex.org/W1981122694","https://openalex.org/W1981578998","https://openalex.org/W1992441515","https://openalex.org/W2007431287","https://openalex.org/W2012314095","https://openalex.org/W2013134830","https://openalex.org/W2042033090","https://openalex.org/W2042545369","https://openalex.org/W2068787593","https://openalex.org/W2070177922","https://openalex.org/W2079143710","https://openalex.org/W2096410299","https://openalex.org/W2098229314","https://openalex.org/W2125866630","https://openalex.org/W2136338627","https://openalex.org/W2140420106","https://openalex.org/W2148603408","https://openalex.org/W2159167363","https://openalex.org/W2161619104","https://openalex.org/W2282922341","https://openalex.org/W2326077896","https://openalex.org/W2418454373","https://openalex.org/W6640561571","https://openalex.org/W6667780762"],"related_works":["https://openalex.org/W374603109","https://openalex.org/W2138511799","https://openalex.org/W2967445610","https://openalex.org/W2047179157","https://openalex.org/W2089451052","https://openalex.org/W7008452261","https://openalex.org/W2767263876","https://openalex.org/W7098562959","https://openalex.org/W3170842578","https://openalex.org/W2550326989"],"abstract_inverted_index":{"Valor":[0],"pron\u00f3stico":[1,156],"de":[2,7,19,26,31,55,61,69,73,101,110,115,118,127,149,162,170],"receptores":[3],"hormonales":[4],"(RRHH),":[5],"expresi\u00f3n":[6,169],"HER-2,":[8,191,217],"ciclinas":[9,86,171],"D1":[10,87,172,193,219,280,349],"y":[11,14,48,66,79,88,93,104,117,138,151,173,175],"D2,":[12,174,195,221],"bcl-2":[13,97,176,196,222,288,353],"ciclooxigenasa-2":[15],"(COX-2)":[16,199],"en":[17,98,107,157,164,179],"pacientes":[18,33,75],"35":[20,211,245],"a\u00f1os":[21],"o":[22],"menores":[23],"con":[24,58,123],"c\u00e1ncer":[25,161],"mama.":[27],"En":[28],"una":[29],"serie":[30],"71":[32,240],"j\u00f3venes,":[34],"cuya":[35],"evoluci\u00f3n":[36],"se":[37,120],"conoc\u00eda,":[38],"analizamos":[39],"por":[40],"segunda":[41],"vez":[42],"las":[43,74],"piezas":[44],"tumorales":[45],"mediante":[46],"inmunohistoqu\u00edmica":[47],"tissue":[49,234],"arrays.":[50],"Evaluamos":[51],"la":[52,62,105,158],"influencia":[53],"pron\u00f3stica":[54],"estos":[56],"factores":[57],"el":[59,67,80,83,91,99,108],"test":[60,261],"chi":[63],"al":[64],"cuadrado":[65],"m\u00e9todo":[68],"Kaplan-Meier.":[70],"El":[71,96],"67%":[72,272],"mostraban":[76],"RRHH":[77,116,137,150],"positivos":[78,90],"48,6%":[81],"sobreexpresaba":[82],"HER-2.":[84],"Fueron":[85],"D2":[89,282,351],"59,1%":[92],"59,7%,":[94],"respectivamente.":[95],"62,5%":[100],"los":[102,111],"casos,":[103],"COX-2":[106,119,152,224,292,300,330],"63,4%":[109],"tumores.":[112],"La":[113,147,168],"positividad":[114],"relacion\u00f3":[121],"significativamente":[122],"un":[124,154],"mayor":[125],"riesgo":[126],"recidiva":[128],"local":[129,310],"(OR":[130],"=":[131,134,140,143],"4,6,":[132],"p":[133,142],"0,03":[135],"para":[136,145],"OR":[139],"3,7,":[141],"0,02":[144],"COX-2).":[146,324],"sobreexpresi\u00f3n":[148],"desempe\u00f1a":[153],"papel":[155],"progresi\u00f3n":[159],"del":[160],"mama":[163],"mujeres":[165],"muy":[166],"j\u00f3venes.":[167],"no":[177,355],"influy\u00f3":[178],"su":[180],"evoluci\u00f3n.":[181],"To":[182],"investigate":[183],"the":[184,202,259,274,336],"value":[185],"of":[186,204,239,253,267,273,295,309,327,338,347],"hormone":[187],"receptor":[188],"(HR)":[189],"status,":[190],"cyclins":[192,218,279,348],"and":[194,197,220,223,233,262,281,285,291,299,318,329,350,352],"cyclooxygenase-2":[198],"in":[200,236,271,277,283,289,293,335,342],"predicting":[201],"outcome":[203],"very":[205,343],"young":[206,344],"breast":[207,296,340],"cancer":[208],"patients":[209,241],"(below":[210],"years).":[212],"In":[213],"this":[214],"study":[215],"HR,":[216],"were":[225,302],"determined":[226],"for":[227,316,323],"a":[228,237,306,333],"second":[229],"time":[230],"by":[231,258],"immunohistochemistry":[232],"arrays":[235],"cohort":[238],"aged":[242],"less":[243],"than":[244],"years":[246],"with":[247,305],"known":[248],"outcome.":[249],"The":[250],"prognostic":[251,356],"influence":[252],"these":[254],"factors":[255],"was":[256,269],"evaluated":[257],"chi-square":[260],"Kaplan":[263],"Meier":[264],"method.":[265],"Expression":[266],"HR":[268,298,317,328],"detected":[270],"patients,":[275],"HER-2":[276],"48.6%,":[278],"59.1%":[284],"59.7%,":[286],"respectively,":[287],"62.5%":[290],"63.4%":[294],"tumors.":[297],"overexpression":[301],"significantly":[303],"correlated":[304],"major":[307],"risk":[308],"relapse":[311],"(OR:":[312],"4.6,":[313],"P":[314,321],"=.03":[315],"OR:":[319],"3.7,":[320],"=.02":[322],"Increased":[325],"expression":[326],"may":[331],"play":[332],"role":[334],"progression":[337],"primary":[339],"carcinoma":[341],"patients.":[345],"Overexpression":[346],"had":[354],"value.":[357]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
