{"id":"https://openalex.org/W2000800050","doi":"https://doi.org/10.1371/journal.pgen.1004239","title":"Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes","display_name":"Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes","publication_year":2014,"publication_date":"2014-03-06","ids":{"openalex":"https://openalex.org/W2000800050","doi":"https://doi.org/10.1371/journal.pgen.1004239","mag":"2000800050","pmid":"https://pubmed.ncbi.nlm.nih.gov/24603726"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1004239","doi":"https://doi.org/10.1371/journal.pgen.1004239","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1004239","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004239&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004239&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089975040","display_name":"Sheli L. Ostrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sheli L. Ostrow","raw_affiliation_strings":["Rachel & Menachem Mendelovitch Evolutionary Processes of Mutation & Natural Selection Research Laboratory, Department of Genetics, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rachel & Menachem Mendelovitch Evolutionary Processes of Mutation & Natural Selection Research Laboratory, Department of Genetics, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087751046","display_name":"Ruth Barshir","orcid":"https://orcid.org/0000-0003-0776-9587","observed_orcids":["https://orcid.org/0000-0003-0776-9587"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ruth Barshir","raw_affiliation_strings":["Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel","Department of Clinical Biochemistry & Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Department of Clinical Biochemistry & Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034184119","display_name":"James V. DeGregori","orcid":"https://orcid.org/0000-0002-1287-1976","observed_orcids":["https://orcid.org/0000-0002-1287-1976"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James DeGregori","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Program in Molecular Biology, Integrated Department of Immunology, University of Colorado School of Medicine, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Program in Molecular Biology, Integrated Department of Immunology, University of Colorado School of Medicine, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059198564","display_name":"Esti Yeger\u2010Lotem","orcid":"https://orcid.org/0000-0002-8279-7898","observed_orcids":["https://orcid.org/0000-0002-8279-7898"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Esti Yeger-Lotem","raw_affiliation_strings":["Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel","Department of Clinical Biochemistry & Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Department of Clinical Biochemistry & Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048491670","display_name":"Ruth Hershberg","orcid":"https://orcid.org/0000-0002-0813-640X","observed_orcids":["https://orcid.org/0000-0002-0813-640X"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ruth Hershberg","raw_affiliation_strings":["Rachel & Menachem Mendelovitch Evolutionary Processes of Mutation & Natural Selection Research Laboratory, Department of Genetics, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rachel & Menachem Mendelovitch Evolutionary Processes of Mutation & Natural Selection Research Laboratory, Department of Genetics, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5048491670"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":4.9568,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.96524254,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"10","issue":"3","first_page":"e1004239","last_page":"e1004239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.9419999718666077},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.9300000071525574},{"id":"https://openalex.org/keywords/purifying-selection","display_name":"purifying selection","score":0.8650000095367432},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/housekeeping-genes","display_name":"housekeeping genes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/somatic-evolution","display_name":"somatic evolution","score":0.6069999933242798},{"id":"https://openalex.org/keywords/cancer-genes","display_name":"cancer genes","score":0.5600000023841858},{"id":"https://openalex.org/keywords/tumor-adaptation","display_name":"tumor adaptation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tumor-initiation-and-progression","display_name":"tumor initiation and progression","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8730995655059814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5911819338798523},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5859570503234863},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.5216705799102783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48437365889549255},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.47037094831466675},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.4536255896091461},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4352005124092102},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.4169095456600189},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3832988142967224},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37982645630836487},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.23022392392158508},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.20697137713432312},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pgen.1004239","doi":"https://doi.org/10.1371/journal.pgen.1004239","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1004239","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004239&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmid:24603726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24603726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2932618","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3945297","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3945297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3945297","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pgen00:1004239","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004239","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:367d0bcbbcbb4ec59348d7e58715b147","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/367d0bcbbcbb4ec59348d7e58715b147","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 10, Iss 3, p e1004239 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/954474","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Cancer_Evolution_Is_Associated_with_Pervasive_Positive_Selection_on_Globally_Expressed_Genes_/954474","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1004239","doi":"https://doi.org/10.1371/journal.pgen.1004239","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1004239","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004239&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4099999964237213}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1583787184","display_name":"Understanding mutation using genome-wide sequence-based approaches","funder_award_id":"321780","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2310783216","display_name":null,"funder_award_id":"R01CA180175","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2396181532","display_name":"Rationally designed targeted therapeutic approaches for NSCLC","funder_award_id":"5r01ca157850-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2493519717","display_name":"A Computational Systems Biology Approach to Reveal the Molecular Basis of Complex Diseases","funder_award_id":"256360","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G321707704","display_name":null,"funder_award_id":"R01-CA157850","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323278","display_name":"Council for Higher Education","ror":"https://ror.org/036mqp197"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000800050.pdf","grobid_xml":"https://content.openalex.org/works/W2000800050.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1907806866","https://openalex.org/W1922526627","https://openalex.org/W1967060514","https://openalex.org/W1969541700","https://openalex.org/W1970614515","https://openalex.org/W1980740976","https://openalex.org/W1981215030","https://openalex.org/W1989773675","https://openalex.org/W2005702974","https://openalex.org/W2007040134","https://openalex.org/W2016763316","https://openalex.org/W2023560061","https://openalex.org/W2027938985","https://openalex.org/W2029353325","https://openalex.org/W2042586732","https://openalex.org/W2059145105","https://openalex.org/W2059437408","https://openalex.org/W2061528014","https://openalex.org/W2062210712","https://openalex.org/W2065172786","https://openalex.org/W2067507447","https://openalex.org/W2071601409","https://openalex.org/W2078684128","https://openalex.org/W2089855871","https://openalex.org/W2101443157","https://openalex.org/W2102795115","https://openalex.org/W2105401801","https://openalex.org/W2106578986","https://openalex.org/W2106813347","https://openalex.org/W2112945902","https://openalex.org/W2115453787","https://openalex.org/W2115622704","https://openalex.org/W2115759361","https://openalex.org/W2118311107","https://openalex.org/W2120109712","https://openalex.org/W2122333508","https://openalex.org/W2123558100","https://openalex.org/W2130503287","https://openalex.org/W2130925862","https://openalex.org/W2137426528","https://openalex.org/W2145573047","https://openalex.org/W2145779272","https://openalex.org/W2146980885","https://openalex.org/W2152124140","https://openalex.org/W2159595936","https://openalex.org/W2159830272","https://openalex.org/W2164683872","https://openalex.org/W2328933230","https://openalex.org/W4210290733","https://openalex.org/W4300196896","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W1481440753","https://openalex.org/W2090450622","https://openalex.org/W1990022233","https://openalex.org/W4386741245","https://openalex.org/W3171514391","https://openalex.org/W4293864595","https://openalex.org/W3014642899","https://openalex.org/W3013784317","https://openalex.org/W3015464442","https://openalex.org/W4378620098"],"abstract_inverted_index":{"Cancer":[0],"is":[1,65,90,144,185,202,224],"an":[2],"evolutionary":[3,27,40,55,83,252],"process":[4,41,56,84,253],"in":[5,80,191,211,262],"which":[6],"cells":[7],"acquire":[8],"new":[9],"transformative,":[10],"proliferative":[11],"and":[12,214,254,266],"metastatic":[13],"capabilities.":[14],"A":[15],"full":[16],"understanding":[17],"of":[18,24,35,38,87,99,102,126,249,258],"cancer":[19,26,54,82,133,169,251,264],"requires":[20],"learning":[21],"the":[22,25,36,53,81,85,100,175,192,196,238,247,250,255],"dynamics":[23,37],"process.":[28],"We":[29,50,106,172],"present":[30],"here":[31],"a":[32,45,95,111,122],"large-scale":[33],"analysis":[34,245],"this":[39],"within":[42,129,183],"tumors,":[43],"with":[44,157],"focus":[46],"on":[47,147,179],"breast":[48],"cancer.":[49,197],"show":[51,108,121],"that":[52,73,114,151,160,174,221,234],"differs":[57],"greatly":[58],"from":[59],"organismal":[60],"(germline)":[61],"evolution.":[62],"Organismal":[63],"evolution":[64],"dominated":[66],"by":[67],"purifying":[68,88],"selection":[69,89,104,128,143,178],"(that":[70],"removes":[71],"mutations":[72],"are":[74,115,135,164,235],"harmful":[75],"to":[76,188,195,205,231],"fitness).":[77],"In":[78],"contrast,":[79],"dominance":[86],"much":[91,96],"reduced,":[92],"allowing":[93],"for":[94,137,166,237],"easier":[97],"detection":[98],"signals":[101],"positive":[103,127,142,177],"(adaptation).":[105],"further":[107],"that,":[109],"as":[110],"group,":[112],"genes":[113,134,150,163,182,208,233,261],"globally":[116,148,161,180,206,259],"expressed":[117,149,162,181,207,260],"across":[118],"human":[119],"tissues":[120],"very":[123],"strong":[124],"signal":[125],"tumors.":[130],"Indeed,":[131],"known":[132],"enriched":[136,165,210],"global":[138],"expression":[139,190],"patterns.":[140],"Yet,":[141],"prevalent":[145],"even":[146],"have":[152],"not":[153,186],"yet":[154,167],"been":[155],"associated":[156],"cancer,":[158],"suggesting":[159],"undiscovered":[168],"related":[170],"functions.":[171,216,242],"find":[173],"increased":[176,200],"tumors":[184],"due":[187,204],"their":[189],"tissue":[193],"relevant":[194],"Rather,":[198],"such":[199],"adaptation":[201,223],"likely":[203],"being":[209],"important":[212,236],"housekeeping":[213],"essential":[215],"Thus,":[217],"our":[218,244],"results":[219],"suggest":[220],"tumor":[222],"most":[225,239],"often":[226],"mediated":[227],"through":[228],"somatic":[229],"changes":[230],"those":[232],"basic":[240],"cellular":[241],"Together,":[243],"reveals":[246],"uniqueness":[248],"particular":[256],"importance":[257],"driving":[263],"initiation":[265],"progression.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
