{"id":"https://openalex.org/W2000799425","doi":"https://doi.org/10.1097/01.coh.0000250321.50408.0a","title":"Outcomes for therapeutic vaccines trials","display_name":"Outcomes for therapeutic vaccines trials","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2000799425","doi":"https://doi.org/10.1097/01.coh.0000250321.50408.0a","mag":"2000799425","pmid":"https://pubmed.ncbi.nlm.nih.gov/19372853"},"language":"en","primary_location":{"id":"doi:10.1097/01.coh.0000250321.50408.0a","doi":"https://doi.org/10.1097/01.coh.0000250321.50408.0a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.coh.0000250321.50408.0a","pdf_url":null,"source":{"id":"https://openalex.org/S106953758","display_name":"Current Opinion in HIV and AIDS","issn_l":"1746-630X","issn":["1746-630X","1746-6318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in HIV and AIDS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015872083","display_name":"Babafemi Taiwo","orcid":"https://orcid.org/0000-0003-2661-9103","observed_orcids":["https://orcid.org/0000-0003-2661-9103"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Babafemi Taiwo","raw_affiliation_strings":["Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA. b-taiwo@northwestern.edu","Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA","to Babafemi Taiwo, Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, IL, USA E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA. b-taiwo@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"to Babafemi Taiwo, Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, IL, USA E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041036157","display_name":"Robert L. Murphy","orcid":"https://orcid.org/0000-0003-3936-2052","observed_orcids":["https://orcid.org/0000-0003-3936-2052","https://orcid.org/0000-0002-9057-5144"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Murphy","raw_affiliation_strings":["Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015872083"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08876322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"6","first_page":"502","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-vaccines","display_name":"therapeutic vaccines","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.8429999947547913},{"id":"https://openalex.org/keywords/structured-treatment-interruption","display_name":"structured treatment interruption","score":0.7850000262260437},{"id":"https://openalex.org/keywords/outcome-measures","display_name":"outcome measures","score":0.5950000286102295},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.7129999995231628},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.8389999866485596},{"id":"https://openalex.org/keywords/virologic-failure","display_name":"virological failure","score":0.8399999737739563},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8640000224113464},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.551045298576355},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.477058082818985},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4736845791339874},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4202394187450409},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33049631118774414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15789619088172913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0892716646194458},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/01.coh.0000250321.50408.0a","doi":"https://doi.org/10.1097/01.coh.0000250321.50408.0a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.coh.0000250321.50408.0a","pdf_url":null,"source":{"id":"https://openalex.org/S106953758","display_name":"Current Opinion in HIV and AIDS","issn_l":"1746-630X","issn":["1746-630X","1746-6318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in HIV and AIDS","raw_type":"journal-article"},{"id":"pmid:19372853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19372853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in HIV and AIDS","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8799999952316284,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W119016558","https://openalex.org/W1497870368","https://openalex.org/W1967378904","https://openalex.org/W2046162941","https://openalex.org/W2054594751","https://openalex.org/W2074821411","https://openalex.org/W2076378967","https://openalex.org/W2079251499","https://openalex.org/W2087113983","https://openalex.org/W2092625183","https://openalex.org/W2113983720","https://openalex.org/W2120092410","https://openalex.org/W2122280827","https://openalex.org/W2126633107","https://openalex.org/W2129630483","https://openalex.org/W2130768495","https://openalex.org/W2132228503","https://openalex.org/W2147004263","https://openalex.org/W2155167450","https://openalex.org/W2155462089","https://openalex.org/W2171141994","https://openalex.org/W2320498484","https://openalex.org/W2327503296"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"This":[3],"article":[4],"briefly":[5],"reviews":[6],"the":[7,19,31,129,158,168,172],"concept":[8],"of":[9,27,34,86,111,135,160],"therapeutic":[10,66,98,136],"vaccination":[11],"in":[12,44,128],"HIV":[13,148],"management,":[14],"with":[15,50,144],"a":[16,192],"focus":[17],"on":[18,30,80,164],"outcomes":[20],"measures":[21,42],"for":[22,53,147],"clinical":[23,63,138,145,169],"trials.":[24],"In":[25],"light":[26],"new":[28],"information":[29],"adverse":[32,130],"consequences":[33],"uncontrolled":[35],"viral":[36,78,123,165,195],"replication":[37,79,124,166],"during":[38],"treatment":[39,88],"interruption,":[40],"outcome":[41],"used":[43],"some":[45,95],"recent":[46],"trials":[47,139,151],"are":[48],"compared":[49],"current":[51],"standards":[52,146],"antiretroviral":[54,185],"therapy.":[55],"RECENT":[56],"FINDINGS:":[57],"Immunogenicity":[58],"may":[59],"not":[60,141],"translate":[61],"to":[62,72,76,97,176,179],"benefit.":[64],"Experimental":[65],"vaccines":[67],"that":[68,93],"were":[69,101,120],"preliminarily":[70],"shown":[71],"be":[73],"immunogenic":[74],"failed":[75],"control":[77],"further":[81],"investigation.":[82],"Two":[83],"major":[84],"studies":[85,173],"structured":[87],"interruption":[89],"-":[90,100],"an":[91],"intervention":[92],"bears":[94],"similarities":[96],"immunization":[99],"prematurely":[102],"discontinued":[103],"by":[104],"data":[105],"safety":[106],"and":[107,167,187],"monitoring":[108],"boards":[109],"because":[110],"worse":[112],"morbidity":[113],"or":[114],"mortality":[115],"among":[116],"patients":[117],"whose":[118],"treatments":[119],"interrupted.":[121],"Uncontrolled":[122],"was":[125],"probably":[126],"culpable":[127],"outcomes.":[131],"SUMMARY:":[132],"The":[133],"design":[134],"vaccine":[137],"has":[140],"kept":[142],"pace":[143],"care.":[149],"Future":[150],"should":[152,174],"evaluate":[153],"immunogenicity,":[154],"but":[155],"also":[156],"investigate":[157],"impact":[159],"vaccine-induced":[161],"immune":[162],"responses":[163],"course.":[170],"Ideally,":[171],"aim":[175],"demonstrate":[177],"non-inferiority":[178],"uninterrupted,":[180],"fully":[181],"suppressive":[182],"highly":[183],"active":[184],"therapy":[186],"define":[188],"virological":[189],"failure":[190],"as":[191],"sustained":[193],"plasma":[194],"load":[196],"greater":[197],"than":[198],"50-400":[199],"copies/ml.":[200]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2025-10-10T00:00:00"}
