{"id":"https://openalex.org/W2000799360","doi":"https://doi.org/10.1097/00000478-200211000-00001","title":"p16INK4a Immunohistochemistry Improves Interobserver Agreement in the Diagnosis of Cervical Intraepithelial Neoplasia","display_name":"p16INK4a Immunohistochemistry Improves Interobserver Agreement in the Diagnosis of Cervical Intraepithelial Neoplasia","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2000799360","doi":"https://doi.org/10.1097/00000478-200211000-00001","mag":"2000799360","pmid":"https://pubmed.ncbi.nlm.nih.gov/12409715"},"language":"en","primary_location":{"id":"doi:10.1097/00000478-200211000-00001","doi":"https://doi.org/10.1097/00000478-200211000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000478-200211000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108537583","display_name":"R\u00fcdiger Klaes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R\u00fcdiger Klaes","raw_affiliation_strings":["Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Germany","(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029575769","display_name":"Axel Benner","orcid":"https://orcid.org/0000-0002-7238-6956","observed_orcids":["https://orcid.org/0000-0002-7238-6956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Axel Benner","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051207638","display_name":"Tibor Friedrich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tibor Friedrich","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059112486","display_name":"R\u00fcdiger Ridder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R\u00fcdiger Ridder","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066889367","display_name":"C. Simon Herrington","orcid":"https://orcid.org/0000-0001-9177-8165","observed_orcids":["https://orcid.org/0000-0001-9177-8165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Herrington","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020263487","display_name":"David  A. Jenkins","orcid":"https://orcid.org/0000-0001-9108-6126","observed_orcids":["https://orcid.org/0000-0001-9108-6126","https://orcid.org/0000-0001-6687-3507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Jenkins","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112159893","display_name":"Robert J. Kurman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J. Kurman","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109219134","display_name":"Dietmar Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dietmar Schmidt","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058641567","display_name":"Mark H. Stoler","orcid":"https://orcid.org/0000-0002-2784-1008","observed_orcids":["https://orcid.org/0000-0002-2784-1008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Stoler","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007438121","display_name":"Magnus von Knebel Doeberitz","orcid":"https://orcid.org/0000-0002-0498-6781","observed_orcids":["https://orcid.org/0000-0002-0498-6781"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Magnus von Knebel Doeberitz","raw_affiliation_strings":["(R.R.)","Germany","Heidelberg","Liverpool","Maryland","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(R.R.)","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Heidelberg","institution_ids":[]},{"raw_affiliation_string":"Liverpool","institution_ids":[]},{"raw_affiliation_string":"Maryland","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007438121"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.0108,"has_fulltext":false,"cited_by_count":461,"citation_normalized_percentile":{"value":0.99205336,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"26","issue":"11","first_page":"1389","last_page":"1399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13309","display_name":"Reliability and Agreement in Measurement","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cervical-intraepithelial-neoplasia","display_name":"cervical intraepithelial neoplasia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interobserver-agreement","display_name":"interobserver agreement","score":0.9350000023841858},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cervical-cancer-diagnosis","display_name":"cervical cancer diagnosis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cervical-conization","display_name":"conization","score":0.7609999775886536},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.824999988079071},{"id":"https://openalex.org/keywords/histopathologic-interpretation","display_name":"histopathologic interpretation","score":0.656000018119812},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.8394832611083984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7831087112426758},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.7126508951187134},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6023252010345459},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5880230069160461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5827748775482178},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5758817195892334},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.5292037725448608},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.46204206347465515},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.420324444770813},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39362627267837524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18723800778388977},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015588","descriptor_name":"Observer Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015588","descriptor_name":"Observer Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015588","descriptor_name":"Observer Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000478-200211000-00001","doi":"https://doi.org/10.1097/00000478-200211000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000478-200211000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:12409715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12409715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/e812c176-535b-4044-8bf3-ec349a95037f","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/e812c176-535b-4044-8bf3-ec349a95037f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klaes, R, Benner, A, Friedrich, T, Ridder, R, Herrington, S, Jenkins, D, Kurman, R J, Schmidt, D, Stoler, M & Doeberitz, M V K 2002, 'p16(INK4a) immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia', American Journal of Surgical Pathology, vol. 26, no. 11, pp. 1389-1399. < http://journals.lww.com/ajsp/Abstract/2002/11000/p16INK4a_Immunohistochemistry_Improves.1.aspx >","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W148873721","https://openalex.org/W1561382837","https://openalex.org/W1566313196","https://openalex.org/W1585000220","https://openalex.org/W1900649908","https://openalex.org/W1958920910","https://openalex.org/W1977636641","https://openalex.org/W1983854492","https://openalex.org/W1985598372","https://openalex.org/W1986993301","https://openalex.org/W1987350137","https://openalex.org/W1987916162","https://openalex.org/W1988558796","https://openalex.org/W1996362313","https://openalex.org/W1998218812","https://openalex.org/W1999113083","https://openalex.org/W2007418914","https://openalex.org/W2026432232","https://openalex.org/W2026993353","https://openalex.org/W2032141702","https://openalex.org/W2039899610","https://openalex.org/W2049541196","https://openalex.org/W2055082270","https://openalex.org/W2068535528","https://openalex.org/W2073439462","https://openalex.org/W2078897896","https://openalex.org/W2095317270","https://openalex.org/W2112500277","https://openalex.org/W2135500874","https://openalex.org/W2141196337","https://openalex.org/W2143019738","https://openalex.org/W2147235018","https://openalex.org/W2149704987","https://openalex.org/W2154270600","https://openalex.org/W2164777277","https://openalex.org/W2331157589","https://openalex.org/W3143504308","https://openalex.org/W4237801062"],"related_works":["https://openalex.org/W3039419443","https://openalex.org/W4386772532","https://openalex.org/W2115661411","https://openalex.org/W2399391471","https://openalex.org/W1513518876","https://openalex.org/W2400254106","https://openalex.org/W2970729894","https://openalex.org/W2485175520","https://openalex.org/W4381996710","https://openalex.org/W2044919438"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"repeatedly":[3],"shown":[4],"that":[5,52],"there":[6],"is":[7],"a":[8,28,88,106],"substantial":[9],"lack":[10],"of":[11,18,45,73,128,143,167,178,201,222],"interobserver":[12,216],"reproducibility":[13],"in":[14,64,71,121,139,164,209,218],"the":[15,46,117,122,140,165,219],"histologic":[16],"diagnosis":[17,123],"cervical":[19,40,74,81,114,194,206,223,240],"intraepithelial":[20],"neoplasia":[21],"(CIN),":[22],"which":[23],"might":[24],"be":[25],"improved":[26],"by":[27,132],"more":[29,60],"specific":[30],"diagnostic":[31,141],"biomarker.":[32],"Cervical":[33],"cancer":[34,207],"and":[35,67,102,104,145,212,232,236],"CIN,":[36],"but":[37],"not":[38],"other":[39],"epithelia,":[41],"express":[42],"high":[43],"levels":[44],"cyclin-dependent":[47],"kinase":[48],"inhibitor":[49],"p16,":[50],"suggesting":[51],"staining":[53],"for":[54,149],"this":[55,78],"marker":[56],"could":[57],"help":[58],"to":[59,182,214],"precisely":[61],"identify":[62],"CIN":[63,183,186,204],"tissue":[65],"sections":[66,94,211],"therefore":[68],"reduce":[69,215,230],"variation":[70,217],"interpretation":[72,142,166,221,235],"lesions.":[75],"To":[76],"test":[77],"hypothesis,":[79],"194":[80],"cone":[82],"biopsy":[83,97,210,224,234],"samples":[84],"were":[85,98,137],"selected":[86],"from":[87,95],"routine":[89],"histopathology":[90],"laboratory.":[91],"Two":[92],"consecutive":[93],"each":[96],"stained":[99],"with":[100,105,189],"hematoxylin":[101,144],"eosin":[103],"p16":[107,168,179,196,227],"-specific":[108],"monoclonal":[109],"antibody,":[110],"respectively.":[111],"Five":[112],"experienced":[113],"pathologists":[115],"examined":[116],"slides.":[118],"The":[119],"agreement":[120,163],"between":[124],"pairs":[125],"or":[126,193,205],"groups":[127],"observers":[129],"was":[130,160,180],"calculated":[131],"kappa":[133],"statistics.":[134],"Significant":[135],"discrepancies":[136],"observed":[138],"eosin-stained":[146],"slides,":[147],"particularly":[148],"low-grade":[150],"lesions":[151,208],"(kappa":[152,170],"value":[153,171],"0.60":[154],"[95%":[155,173],"confidence":[156,174],"interval":[157,175],"0.58-0.63]).":[158],"There":[159],"significantly":[161,238],"better":[162],"expression":[169],"0.91":[172],"0.84-0.99]).":[176],"Expression":[177],"restricted":[181],"2/CIN":[184],"3,":[185],"1":[187],"associated":[188],"high-risk":[190],"human":[191],"papillomavirus,":[192],"cancer.":[195],"immunostaining":[197],"allowed":[198],"precise":[199],"identification":[200],"even":[202],"small":[203],"helped":[213],"histopathologic":[220],"specimens.":[225],"Thus,":[226],"immunohistochemistry":[228],"can":[229],"false-negative":[231],"false-positive":[233],"thereby":[237],"improve":[239],"(pre)-cancer":[241],"diagnosis.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":29}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}