{"id":"https://openalex.org/W2000798390","doi":"https://doi.org/10.1093/biomet/asm019","title":"Estimating a treatment effect with repeated measurements accounting for varying effectiveness duration","display_name":"Estimating a treatment effect with repeated measurements accounting for varying effectiveness duration","publication_year":2007,"publication_date":"2007-02-28","ids":{"openalex":"https://openalex.org/W2000798390","doi":"https://doi.org/10.1093/biomet/asm019","mag":"2000798390"},"language":"en","primary_location":{"id":"doi:10.1093/biomet/asm019","doi":"https://doi.org/10.1093/biomet/asm019","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biomet/asm019","pdf_url":null,"source":{"id":"https://openalex.org/S172180718","display_name":"Biometrika","issn_l":"0006-3444","issn":["0006-3444","1464-3510"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a-star","anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biometrika","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082586932","display_name":"Ying Qing Chen","orcid":"https://orcid.org/0000-0002-2726-3391","observed_orcids":["https://orcid.org/0000-0002-2726-3391","https://orcid.org/0009-0001-9690-0673"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Q. Chen","raw_affiliation_strings":["Program in Biostatistics, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, U.S.A","Fred Hutchinson Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Biostatistics, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, U.S.A","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075850581","display_name":"Jing Zhao Yang","orcid":"https://orcid.org/0000-0002-3295-4154","observed_orcids":["https://orcid.org/0000-0002-3295-4154"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Yang","raw_affiliation_strings":["Divisions of Biostatistics & Epidemiology, School of Public Health, University of California, Berkeley, California 94720, U.S.A","University of California at Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Biostatistics & Epidemiology, School of Public Health, University of California, Berkeley, California 94720, U.S.A","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California at Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102736870","display_name":"S. Cheng","orcid":"https://orcid.org/0009-0002-9723-004X","observed_orcids":["https://orcid.org/0009-0002-9723-004X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Cheng","raw_affiliation_strings":["Department of Biostatistics & Epidemiology, University of California, San Francisco, California 94143, U.S.A","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Epidemiology, University of California, San Francisco, California 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000033990","display_name":"J. Brooks Jackson","orcid":"https://orcid.org/0000-0001-9458-135X","observed_orcids":["https://orcid.org/0000-0001-9458-135X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. B. Jackson","raw_affiliation_strings":["Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, U.S.A","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2724,"currency":"GBP","value_usd":3592},"apc_paid":null,"fwci":0.3003,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64639155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"94","issue":"2","first_page":"387","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.23929999768733978,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treatment-effect-estimation","display_name":"treatment effect estimation","score":0.949999988079071},{"id":"https://openalex.org/keywords/repeated-measures","display_name":"repeated measures","score":0.9309999942779541},{"id":"https://openalex.org/keywords/time-delay","display_name":"time delay","score":0.7490000128746033},{"id":"https://openalex.org/keywords/saturation-time","display_name":"saturation time","score":0.9070000052452087},{"id":"https://openalex.org/keywords/time-varying-parameters","display_name":"time-varying parameters","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hiv-aids-clinical-trials","display_name":"HIV/AIDS clinical trials","score":0.5820000171661377},{"id":"https://openalex.org/keywords/nevirapine","display_name":"nevirapine","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mother-to-child-hiv-transmission","display_name":"mother-to-child HIV transmission","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vertical-transmission","display_name":"vertical transmission","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C102366305","wikidata":"https://www.wikidata.org/wiki/Q1097688","display_name":"Nonparametric statistics","level":2,"score":0.6185266375541687},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.6103411912918091},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5972890853881836},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.5970445275306702},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5817579627037048},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.5396113395690918},{"id":"https://openalex.org/C2987370644","wikidata":"https://www.wikidata.org/wiki/Q7836903","display_name":"Treatment effect","level":2,"score":0.531245231628418},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.49476689100265503},{"id":"https://openalex.org/C2779130552","wikidata":"https://www.wikidata.org/wiki/Q263713","display_name":"Nevirapine","level":5,"score":0.46804237365722656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43954646587371826},{"id":"https://openalex.org/C75778745","wikidata":"https://www.wikidata.org/wiki/Q342626","display_name":"Lag","level":2,"score":0.42794084548950195},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.280211865901947},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19046714901924133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12495729327201843},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/biomet/asm019","doi":"https://doi.org/10.1093/biomet/asm019","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biomet/asm019","pdf_url":null,"source":{"id":"https://openalex.org/S172180718","display_name":"Biometrika","issn_l":"0006-3444","issn":["0006-3444","1464-3510"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a-star","anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biometrika","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:oup:biomet:v:94:y:2007:i:2:p:387-402","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10.1093/biomet/asm019","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:biostats.bepress.com:uwbiostat-1098","doi":null,"is_oa":false,"landing_page_url":"https://biostats.bepress.com/uwbiostat/paper265","pdf_url":null,"source":{"id":"https://openalex.org/S4377196124","display_name":"Collection of Biostatistics Research Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UW Biostatistics Working Paper Series","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:biomet:asm019v1","doi":null,"is_oa":false,"landing_page_url":"http://biomet.oxfordjournals.org/cgi/content/short/asm019v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W206706296","https://openalex.org/W1497683195","https://openalex.org/W1592984998","https://openalex.org/W1982400467","https://openalex.org/W1985309647","https://openalex.org/W1987067784","https://openalex.org/W1990105675","https://openalex.org/W1999975842","https://openalex.org/W2003946283","https://openalex.org/W2005206478","https://openalex.org/W2009259977","https://openalex.org/W2012658469","https://openalex.org/W2014366116","https://openalex.org/W2029126177","https://openalex.org/W2033158547","https://openalex.org/W2054957279","https://openalex.org/W2060007416","https://openalex.org/W2060467039","https://openalex.org/W2069541127","https://openalex.org/W2079219970","https://openalex.org/W2083123688","https://openalex.org/W2083550322","https://openalex.org/W2089151634","https://openalex.org/W2089785797","https://openalex.org/W2094556422","https://openalex.org/W2109766022","https://openalex.org/W2113933699","https://openalex.org/W2131940376","https://openalex.org/W2141929736","https://openalex.org/W2149860264","https://openalex.org/W2156963621","https://openalex.org/W2795929191","https://openalex.org/W2797333853","https://openalex.org/W2797583072"],"related_works":["https://openalex.org/W4250316256","https://openalex.org/W4301807426","https://openalex.org/W4300351178","https://openalex.org/W2603130550","https://openalex.org/W2140384375","https://openalex.org/W2105776266","https://openalex.org/W2047555579","https://openalex.org/W4246320660","https://openalex.org/W4300562749","https://openalex.org/W2911847370"],"abstract_inverted_index":{"To":[0],"assess":[1],"treatment":[2,27,30,40,65,89],"efficacy":[3],"in":[4,21],"clinical":[5,8,104],"trials,":[6],"certain":[7],"outcomes":[9],"are":[10,69],"repeatedly":[11],"measured":[12],"over":[13],"time":[14,71],"for":[15],"the":[16,45,64,70,74],"same":[17],"subject.":[18],"The":[19],"difference":[20],"their":[22],"means":[23],"may":[24,36],"characterize":[25],"a":[26,101],"effect.":[28],"Since":[29],"effectiveness":[31,66,90],"lag":[32,75],"and":[33,76,98,116],"saturation":[34,77],"times":[35],"exist,":[37],"erosion":[38],"of":[39,49,100,106],"effect":[41],"often":[42],"occurs":[43],"during":[44,114],"observation":[46],"period.":[47],"Instead":[48],"using":[50],"models":[51,85],"based":[52],"on":[53],"ad":[54],"hoc":[55],"parametric":[56],"or":[57],"purely":[58],"nonparametric":[59],"time-varying":[60],"coefficients,":[61],"we":[62,80],"model":[63],"durations,":[67],"which":[68],"intervals":[72],"between":[73],"times.":[78],"Then":[79],"use":[81],"some":[82],"mean":[83],"response":[84],"to":[86],"include":[87],"such":[88],"durations.":[91],"Our":[92],"methodology":[93],"is":[94],"demonstrated":[95],"by":[96],"simulations":[97],"analysis":[99],"landmark":[102],"HIV/AIDS":[103],"trial":[105],"short-course":[107],"nevirapine":[108],"against":[109],"mother-to-child":[110],"HIV":[111],"vertical":[112],"transmission":[113],"labour":[115],"delivery.":[117]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2025-10-10T00:00:00"}