{"id":"https://openalex.org/W2000793812","doi":"https://doi.org/10.1016/j.gde.2008.10.002","title":"Eukaryotic gene regulation in three dimensions and its impact on genome evolution","display_name":"Eukaryotic gene regulation in three dimensions and its impact on genome evolution","publication_year":2008,"publication_date":"2008-11-29","ids":{"openalex":"https://openalex.org/W2000793812","doi":"https://doi.org/10.1016/j.gde.2008.10.002","mag":"2000793812","pmid":"https://pubmed.ncbi.nlm.nih.gov/19007886"},"language":"en","primary_location":{"id":"doi:10.1016/j.gde.2008.10.002","doi":"https://doi.org/10.1016/j.gde.2008.10.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2008.10.002","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics &amp; Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101784807","display_name":"M. Madan Babu","orcid":"https://orcid.org/0000-0003-0556-6196","observed_orcids":["https://orcid.org/0000-0003-0556-6196"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Madan Babu","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, UK. madanm@mrc-lmb.cam.ac.uk","MRC-Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, UK. madanm@mrc-lmb.cam.ac.uk","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC-Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066167699","display_name":"Sarath Chandra Janga","orcid":"https://orcid.org/0000-0001-7351-6268","observed_orcids":["https://orcid.org/0000-0001-7351-6268"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarath Chandra Janga","raw_affiliation_strings":["MRC-Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC-Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005430069","display_name":"Ines de Santiago","orcid":"https://orcid.org/0000-0003-2126-8287","observed_orcids":["https://orcid.org/0000-0003-2126-8287","https://orcid.org/0000-0002-8172-1322"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Ines de Santiago","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070136083","display_name":"Ana Pombo","orcid":"https://orcid.org/0000-0002-7493-6288","observed_orcids":["https://orcid.org/0000-0002-7493-6288"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana Pombo","raw_affiliation_strings":["MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.7069,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.54786918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"6","first_page":"571","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-genome-organization","display_name":"3D genome organization","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/genome-evolution","display_name":"genome evolution","score":0.7149999737739563},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.6399999856948853},{"id":"https://openalex.org/keywords/chromosome-organization","display_name":"chromosome organization","score":0.7160000205039978},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8684319257736206},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6690967082977295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6181102395057678},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6049312353134155},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5373432040214539},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4964905381202698},{"id":"https://openalex.org/C22322919","wikidata":"https://www.wikidata.org/wiki/Q5533501","display_name":"Genomic organization","level":4,"score":0.44081833958625793},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.43922698497772217},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4326101541519165},{"id":"https://openalex.org/C93946551","wikidata":"https://www.wikidata.org/wiki/Q5113914","display_name":"Chromosome conformation capture","level":5,"score":0.4208984971046448},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.4113103747367859},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2531704902648926},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.21209892630577087},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.07985502481460571}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.gde.2008.10.002","doi":"https://doi.org/10.1016/j.gde.2008.10.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2008.10.002","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics &amp; Development","raw_type":"journal-article"},{"id":"pmid:19007886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19007886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in genetics & development","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:13313","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/13313/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W1951165114","https://openalex.org/W1963634449","https://openalex.org/W1964801370","https://openalex.org/W1966794959","https://openalex.org/W1968384393","https://openalex.org/W1968887640","https://openalex.org/W1968978297","https://openalex.org/W1972516690","https://openalex.org/W1975290221","https://openalex.org/W1977316264","https://openalex.org/W1979076392","https://openalex.org/W1985843769","https://openalex.org/W1987362169","https://openalex.org/W1988195130","https://openalex.org/W1990396035","https://openalex.org/W1991149014","https://openalex.org/W1992305237","https://openalex.org/W1993570130","https://openalex.org/W1997814909","https://openalex.org/W1999155341","https://openalex.org/W2003931365","https://openalex.org/W2004466756","https://openalex.org/W2005205149","https://openalex.org/W2005944417","https://openalex.org/W2009199987","https://openalex.org/W2010032067","https://openalex.org/W2011170131","https://openalex.org/W2016294887","https://openalex.org/W2017549616","https://openalex.org/W2019666363","https://openalex.org/W2019923915","https://openalex.org/W2020977773","https://openalex.org/W2026180423","https://openalex.org/W2027279861","https://openalex.org/W2028022357","https://openalex.org/W2029229130","https://openalex.org/W2029873987","https://openalex.org/W2032510252","https://openalex.org/W2038774969","https://openalex.org/W2040544622","https://openalex.org/W2041962354","https://openalex.org/W2041973176","https://openalex.org/W2043485308","https://openalex.org/W2046154818","https://openalex.org/W2047734673","https://openalex.org/W2048485003","https://openalex.org/W2049855310","https://openalex.org/W2052586663","https://openalex.org/W2052921451","https://openalex.org/W2053206914","https://openalex.org/W2057341073","https://openalex.org/W2057857382","https://openalex.org/W2058402081","https://openalex.org/W2060392690","https://openalex.org/W2061015334","https://openalex.org/W2062272897","https://openalex.org/W2064038671","https://openalex.org/W2066162643","https://openalex.org/W2067049849","https://openalex.org/W2068364245","https://openalex.org/W2068365329","https://openalex.org/W2070196639","https://openalex.org/W2071789393","https://openalex.org/W2073026107","https://openalex.org/W2074762238","https://openalex.org/W2076142853","https://openalex.org/W2076583739","https://openalex.org/W2077154575","https://openalex.org/W2083519349","https://openalex.org/W2085110456","https://openalex.org/W2087973273","https://openalex.org/W2088727054","https://openalex.org/W2092499706","https://openalex.org/W2096698736","https://openalex.org/W2098549100","https://openalex.org/W2101722176","https://openalex.org/W2101755447","https://openalex.org/W2109264912","https://openalex.org/W2109845157","https://openalex.org/W2111012767","https://openalex.org/W2112124900","https://openalex.org/W2117717914","https://openalex.org/W2120951141","https://openalex.org/W2122887139","https://openalex.org/W2128787099","https://openalex.org/W2129221378","https://openalex.org/W2129378637","https://openalex.org/W2130529538","https://openalex.org/W2136223090","https://openalex.org/W2139519979","https://openalex.org/W2146470265","https://openalex.org/W2151880666","https://openalex.org/W2158845372","https://openalex.org/W2161316685","https://openalex.org/W2161493476","https://openalex.org/W2162235906","https://openalex.org/W2166760304","https://openalex.org/W2166763687","https://openalex.org/W2167331352","https://openalex.org/W2168857762","https://openalex.org/W2169495050","https://openalex.org/W2615476639","https://openalex.org/W3180274570","https://openalex.org/W4214677910"],"related_works":["https://openalex.org/W2803562279","https://openalex.org/W2115685806","https://openalex.org/W3044940045","https://openalex.org/W2374108210","https://openalex.org/W2884100980","https://openalex.org/W2792792541","https://openalex.org/W2010962548","https://openalex.org/W2066162643","https://openalex.org/W2989129562","https://openalex.org/W4360611266"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
