{"id":"https://openalex.org/W2000770413","doi":"https://doi.org/10.1016/0049-3848(80)90221-2","title":"Failure of aspirin at different doses to modify experimental thrombosis in rats","display_name":"Failure of aspirin at different doses to modify experimental thrombosis in rats","publication_year":1980,"publication_date":"1980-06-01","ids":{"openalex":"https://openalex.org/W2000770413","doi":"https://doi.org/10.1016/0049-3848(80)90221-2","mag":"2000770413","pmid":"https://pubmed.ncbi.nlm.nih.gov/7414553"},"language":"en","primary_location":{"id":"doi:10.1016/0049-3848(80)90221-2","doi":"https://doi.org/10.1016/0049-3848(80)90221-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0049-3848(80)90221-2","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049042171","display_name":"Ine Reyers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ine Reyers","raw_affiliation_strings":["Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107347284","display_name":"L. Mussoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luciana Mussoni","raw_affiliation_strings":["Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061373096","display_name":"Maria Benedetta Donati","orcid":"https://orcid.org/0000-0003-1747-5443","observed_orcids":["https://orcid.org/0000-0003-1747-5443","https://orcid.org/0000-0002-9163-8194"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Benedetta Donati","raw_affiliation_strings":["Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089109611","display_name":"Giovanni de Gaetano","orcid":"https://orcid.org/0000-0002-7823-1402","observed_orcids":["https://orcid.org/0000-0002-7823-1402","https://orcid.org/0000-0001-6840-4771"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni de Gaetano","raw_affiliation_strings":["Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Haemostasis and Thrombosis Research and Laboratory of Cardiovascular Clinical Pharmacology - Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 - Via Eritrea, 62 - 20157 MILAN, Italy","institution_ids":["https://openalex.org/I19630809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19630809"],"apc_list":{"value":4080,"currency":"USD","value_usd":4080},"apc_paid":null,"fwci":2.5958,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.88766923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"5","first_page":"669","last_page":"674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.4133000075817108,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.4133000075817108,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.31299999356269836,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.17919999361038208,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antithrombotic-activity","display_name":"antithrombotic activity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/experimental-thrombosis","display_name":"experimental thrombosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6909999847412109},{"id":"https://openalex.org/keywords/vascular-prostacyclin","display_name":"vascular prostacyclin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9660000205039978},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/venous-thrombosis","display_name":"venous thrombosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.9157247543334961},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.8485471606254578},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.8462032079696655},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8029321432113647},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6929190158843994},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6915504336357117},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.6870735287666321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5804839730262756},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.552589476108551},{"id":"https://openalex.org/C2777265216","wikidata":"https://www.wikidata.org/wiki/Q721432","display_name":"Antiplatelet drug","level":4,"score":0.5043963193893433},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43605655431747437},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.4285689890384674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4253040552139282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2939920425415039},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22139933705329895},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10800281167030334},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.10013008117675781}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0049-3848(80)90221-2","doi":"https://doi.org/10.1016/0049-3848(80)90221-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0049-3848(80)90221-2","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},{"id":"pmid:7414553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7414553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1983759759","https://openalex.org/W1998907122","https://openalex.org/W2016079930","https://openalex.org/W2021403302","https://openalex.org/W2030702205","https://openalex.org/W2043580911","https://openalex.org/W2057237616","https://openalex.org/W2077459776","https://openalex.org/W2090703693","https://openalex.org/W2102395898","https://openalex.org/W2338414925","https://openalex.org/W6664876995"],"related_works":["https://openalex.org/W2030702205","https://openalex.org/W2883271261","https://openalex.org/W2470479143","https://openalex.org/W2091617682","https://openalex.org/W2137265742","https://openalex.org/W2102395898","https://openalex.org/W2063884400","https://openalex.org/W2002950370","https://openalex.org/W2092011140","https://openalex.org/W2073909820"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}