{"id":"https://openalex.org/W2000765956","doi":"https://doi.org/10.1021/bi900623r","title":"Mechanism of the Orotidine 5\u2032-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,","display_name":"Mechanism of the Orotidine 5\u2032-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,","publication_year":2009,"publication_date":"2009-05-12","ids":{"openalex":"https://openalex.org/W2000765956","doi":"https://doi.org/10.1021/bi900623r","mag":"2000765956","pmid":"https://pubmed.ncbi.nlm.nih.gov/19435314","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2697262"},"language":"en","primary_location":{"id":"doi:10.1021/bi900623r","doi":"https://doi.org/10.1021/bi900623r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi900623r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2697262/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050724615","display_name":"Kui K. Chan","orcid":"https://orcid.org/0000-0002-6351-2885","observed_orcids":["https://orcid.org/0000-0002-6351-2885"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kui K. Chan","raw_affiliation_strings":["Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111632348","display_name":"B.M. Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. McKay Wood","raw_affiliation_strings":["Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077718436","display_name":"Alexander A. Fedorov","orcid":"https://orcid.org/0000-0002-7911-3301","observed_orcids":["https://orcid.org/0000-0002-7911-3301"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Fedorov","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461","Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061121659","display_name":"E.V. Fedorov","orcid":"https://orcid.org/0000-0003-2121-7092","observed_orcids":["https://orcid.org/0000-0003-2121-7092"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena V. Fedorov","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461","Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058438038","display_name":"H.J. Imker","orcid":"https://orcid.org/0000-0003-4748-7453","observed_orcids":["https://orcid.org/0000-0003-4748-7453"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi J. Imker","raw_affiliation_strings":["Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062838517","display_name":"Tina L. Amyes","orcid":"https://orcid.org/0000-0001-5393-549X","observed_orcids":["https://orcid.org/0000-0001-5393-549X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina L. Amyes","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, Buffalo, New York 14260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, Buffalo, New York 14260","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066402611","display_name":"John P. Richard","orcid":"https://orcid.org/0000-0002-0440-2387","observed_orcids":["https://orcid.org/0000-0002-0440-2387"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Richard","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, Buffalo, New York 14260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, Buffalo, New York 14260","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006013523","display_name":"Steven C. Almo","orcid":"https://orcid.org/0000-0003-2591-5234","observed_orcids":["https://orcid.org/0000-0003-2591-5234"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven C. Almo","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461","Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091252875","display_name":"J.A. Gerlt","orcid":"https://orcid.org/0000-0002-5625-1218","observed_orcids":["https://orcid.org/0000-0002-5625-1218"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John A. Gerlt","raw_affiliation_strings":["Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006013523","https://openalex.org/A5091252875"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I157725225","https://openalex.org/I19772626"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.3597,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.88810254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"48","issue":"24","first_page":"5518","last_page":"5531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orotidine-5-phosphate-decarboxylase","display_name":"orotidine 5'-monophosphate decarboxylase","score":0.984000027179718},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.6150000095367432},{"id":"https://openalex.org/keywords/reaction-rate-enhancement","display_name":"reaction rate enhancement","score":0.609000027179718},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.6880000233650208},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.4909999966621399},{"id":"https://openalex.org/keywords/active-site-conformation","display_name":"active site conformation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/methanothermobacter-thermautotrophicus","display_name":"Methanothermobacter thermautotrophicus","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7766523361206055},{"id":"https://openalex.org/C2780595602","wikidata":"https://www.wikidata.org/wiki/Q898436","display_name":"Decarboxylation","level":3,"score":0.7064159512519836},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6770504117012024},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6255446672439575},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6195840835571289},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.530256450176239},{"id":"https://openalex.org/C2781281423","wikidata":"https://www.wikidata.org/wiki/Q268414","display_name":"Pyruvate decarboxylase","level":4,"score":0.49770262837409973},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.48796266317367554},{"id":"https://openalex.org/C63338738","wikidata":"https://www.wikidata.org/wiki/Q287862","display_name":"Catalytic cycle","level":3,"score":0.4460391700267792},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4387323558330536},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.41975387930870056},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.37875279784202576},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33281147480010986},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.33162200450897217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1620996594429016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07011395692825317},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009964","descriptor_name":"Orotidine-5'-Phosphate Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009964","descriptor_name":"Orotidine-5'-Phosphate Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009964","descriptor_name":"Orotidine-5'-Phosphate Decarboxylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017013","descriptor_name":"Methanobacteriaceae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi900623r","doi":"https://doi.org/10.1021/bi900623r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi900623r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:19435314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19435314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2697262","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2697262/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2697262","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2697262/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2041850897","display_name":null,"funder_award_id":"GM039754","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3247889075","display_name":"STRUCTURAL BASES FOR CATALYTIC EFFICIENCY AND SUBSTRATE SPECIFICITY","funder_award_id":"R01GM065155","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6436314706","display_name":"Resource for Biocomputing, Visualization, and Informatics","funder_award_id":"P41RR001081","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6922446017","display_name":"REACTIVE INTERMEDIATES OF ENZYMATIC REACTIONS","funder_award_id":"R01GM039754","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W68080587","https://openalex.org/W1516078818","https://openalex.org/W1539796472","https://openalex.org/W1912410317","https://openalex.org/W1964553975","https://openalex.org/W1972607828","https://openalex.org/W1973985711","https://openalex.org/W1982177011","https://openalex.org/W1987038760","https://openalex.org/W1987750488","https://openalex.org/W1992321585","https://openalex.org/W1995017064","https://openalex.org/W1997369874","https://openalex.org/W2001641653","https://openalex.org/W2009251620","https://openalex.org/W2015492400","https://openalex.org/W2017403840","https://openalex.org/W2026258117","https://openalex.org/W2030640491","https://openalex.org/W2030942277","https://openalex.org/W2046997698","https://openalex.org/W2049050207","https://openalex.org/W2051540745","https://openalex.org/W2052947365","https://openalex.org/W2062141941","https://openalex.org/W2073264429","https://openalex.org/W2073841072","https://openalex.org/W2079049996","https://openalex.org/W2081803990","https://openalex.org/W2084575458","https://openalex.org/W2084754136","https://openalex.org/W2092978559","https://openalex.org/W2094645941","https://openalex.org/W2097505963","https://openalex.org/W2102562821","https://openalex.org/W2108467824","https://openalex.org/W2117514600","https://openalex.org/W2118818078","https://openalex.org/W2132629607","https://openalex.org/W2142322696"],"related_works":["https://openalex.org/W2010188270","https://openalex.org/W2335976187","https://openalex.org/W2279544568","https://openalex.org/W2966834480","https://openalex.org/W68044144","https://openalex.org/W1974383143","https://openalex.org/W3001457579","https://openalex.org/W1972992743","https://openalex.org/W2026258117","https://openalex.org/W2092978559"],"abstract_inverted_index":{"The":[0,80,173],"reaction":[1],"catalyzed":[2],"by":[3,154],"orotidine":[4],"5'-monophosphate":[5],"decarboxylase":[6],"(OMPDC)":[7],"involves":[8],"a":[9,61,111,276,303],"stabilized":[10],"anionic":[11],"intermediate,":[12],"although":[13],"the":[14,18,35,46,51,65,72,83,106,129,160,168,182,200,213,229,242,262,265,270,273,278,285,309],"structural":[15,155],"basis":[16],"for":[17,175,186,204,290,302],"rate":[19,66],"acceleration":[20,67],"(k(cat)/k(non),":[21],"7.1":[22],"x":[23,29],"10(16))":[24],"and":[25,41,74,110,118,138,156,162,167,218,247,269,297],"proficiency":[26],"[(k(cat)/K(M))/k(non),":[27],"4.8":[28],"10(22)":[30],"M(-1)]":[31],"is":[32,93],"uncertain.":[33],"That":[34],"OMPDCs":[36],"from":[37],"Methanothermobacter":[38],"thermautotrophicus":[39],"(MtOMPDC)":[40],"Saccharomyces":[42],"cerevisiae":[43],"(ScOMPDC)":[44],"catalyze":[45,236],"exchange":[47,205,237,298],"of":[48,50,60,71,82,94,99,159,165,171,184,188,202,206,208,215,232,238,240,244,264,272,288,293,311],"H6":[49,207,239],"UMP":[52],"product":[53],"with":[54,69,210,225,256,258],"solvent":[55,211],"deuterium":[56],"allows":[57],"an":[58],"estimate":[59],"lower":[62],"limit":[63],"on":[64,97,199,295],"associated":[68],"stabilization":[70],"intermediate":[73,305],"its":[75,219,248],"flanking":[76],"transition":[77],"states":[78],"(>or=10(10)).":[79],"origin":[81],"\"missing\"":[84],"contribution,":[85],"<or=10(7)":[86],"(":[87],"approximately":[88],"10(17)":[89],"total":[90],"-":[91],">or=10(10)),":[92],"interest.":[95],"Based":[96],"structures":[98,214,243],"liganded":[100],"complexes,":[101],"unfavorable":[102],"electrostatic":[103],"interactions":[104],"between":[105],"substrate":[107,193,315],"carboxylate":[108],"group":[109],"proximal":[112],"Asp":[113,119,176,291,312],"(Asp":[114],"70":[115,177,292,313],"in":[116,121,178,260,314],"MtOMPDC":[117,166,179,217,294],"91":[120],"ScOMPDC)":[122],"have":[123,196],"been":[124],"proposed":[125],"to":[126,128],"contribute":[127],"catalytic":[130],"efficiency":[131],"[Wu,":[132],"N.,":[133],"Mo,":[134],"Y.,":[135],"Gao,":[136],"J.,":[137],"Pai,":[139],"E.":[140],"F.":[141],"(2000)":[142],"Proc.":[143],"Natl.":[144],"Acad.":[145],"Sci.":[146],"U.S.A.":[147],"97,":[148],"2017-2022].":[149],"We":[150,282],"investigated":[151],"that":[152,284],"hypothesis":[153],"functional":[157],"characterization":[158],"D70N":[161],"D70G":[163],"mutants":[164,220],"D91N":[169,230,249],"mutant":[170,231,250],"ScOMPDC.":[172],"substitutions":[174,289],"significantly":[180],"decrease":[181],"value":[183,201],"k(cat)":[185],"decarboxylation":[187,296],"FOMP":[189],"(a":[190],"more":[191],"reactive":[192],"analogue)":[194],"but":[195],"little":[197],"effect":[198],"k(ex)":[203],"FUMP":[209],"deuterium;":[212],"wild-type":[216,245],"are":[221,251],"superimposable":[222,253],"when":[223,254],"complexed":[224,255],"6-azaUMP.":[226],"In":[227],"contrast,":[228],"ScOMPDC":[233,246],"does":[234],"not":[235,252],"FUMP;":[241],"6-azaUMP,":[257],"differences":[259],"both":[261],"conformation":[263],"active":[266,279],"site":[267,280],"loop":[268],"orientation":[271],"ligand":[274],"vis":[275,277],"residues.":[281],"propose":[283],"differential":[286],"effects":[287],"provide":[299],"additional":[300],"evidence":[301],"carbanionic":[304],"as":[306,308],"well":[307],"involvement":[310],"destabilization.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
