{"id":"https://openalex.org/W2000760328","doi":"https://doi.org/10.1002/bdra.10022","title":"Pathogenic pathways in fluconazole\u2010induced branchial arch malformations","display_name":"Pathogenic pathways in fluconazole\u2010induced branchial arch malformations","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2000760328","doi":"https://doi.org/10.1002/bdra.10022","mag":"2000760328","pmid":"https://pubmed.ncbi.nlm.nih.gov/12769507"},"language":"en","primary_location":{"id":"doi:10.1002/bdra.10022","doi":"https://doi.org/10.1002/bdra.10022","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.10022","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024601621","display_name":"Elena Menegola","orcid":"https://orcid.org/0000-0001-5558-3459","observed_orcids":["https://orcid.org/0000-0001-5558-3459"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Menegola","raw_affiliation_strings":["Department of Biology, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111592539","display_name":"Maria Luisa Broccia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria L. Broccia","raw_affiliation_strings":["Department of Biology, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054032151","display_name":"Francesca Di Renzo","orcid":"https://orcid.org/0000-0003-0200-4673","observed_orcids":["https://orcid.org/0000-0003-0200-4673"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Di Renzo","raw_affiliation_strings":["Department of Biology, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073181567","display_name":"Erminio Giavini","orcid":"https://orcid.org/0000-0003-2578-9936","observed_orcids":["https://orcid.org/0000-0003-2578-9936"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Erminio Giavini","raw_affiliation_strings":["Department of Biology, University of Milan, Milan, Italy","University of Milan, Department of Biology, Via Celoria, 26, 20133 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"University of Milan, Department of Biology, Via Celoria, 26, 20133 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073181567"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":null,"apc_paid":null,"fwci":1.9857,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.84975914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"67","issue":"2","first_page":"116","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.18529999256134033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":1.0},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/neural-crest-migration","display_name":"neural crest migration","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hindbrain","display_name":"hindbrain","score":0.8560000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.42899999022483826},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":1.0},{"id":"https://openalex.org/keywords/ectomesenchyme","display_name":"ectomesenchyme","score":0.6449999809265137},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.656000018119812},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.7350000143051147},{"id":"https://openalex.org/keywords/rat-embryo","display_name":"rat embryo","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.8495697975158691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.772253692150116},{"id":"https://openalex.org/C2778094651","wikidata":"https://www.wikidata.org/wiki/Q3621760","display_name":"Branchial arch","level":3,"score":0.7546361088752747},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.6950066089630127},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5626705288887024},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.44418591260910034},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3697243332862854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35160279273986816},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32121315598487854},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2992321848869324},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2847626209259033},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1374627947807312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001934","descriptor_name":"Branchial Region","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D001934","descriptor_name":"Branchial Region","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005326","descriptor_name":"Fetal Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044022","descriptor_name":"Receptor, Endothelin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bdra.10022","doi":"https://doi.org/10.1002/bdra.10022","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.10022","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},{"id":"pmid:12769507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12769507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research. Part A, Clinical and molecular teratology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W44898985","https://openalex.org/W147163756","https://openalex.org/W286558086","https://openalex.org/W359355672","https://openalex.org/W591646619","https://openalex.org/W1167548001","https://openalex.org/W1492034395","https://openalex.org/W1578865669","https://openalex.org/W1605271345","https://openalex.org/W1951243148","https://openalex.org/W1983168737","https://openalex.org/W1994492935","https://openalex.org/W1994951476","https://openalex.org/W2000370098","https://openalex.org/W2004560416","https://openalex.org/W2009713310","https://openalex.org/W2018954579","https://openalex.org/W2024002091","https://openalex.org/W2043880350","https://openalex.org/W2051168135","https://openalex.org/W2056304485","https://openalex.org/W2059586911","https://openalex.org/W2062830247","https://openalex.org/W2065518361","https://openalex.org/W2086614318","https://openalex.org/W2090757258","https://openalex.org/W2110292170","https://openalex.org/W2118793302","https://openalex.org/W2122877713","https://openalex.org/W2159940087","https://openalex.org/W2161349107","https://openalex.org/W2172307204","https://openalex.org/W2173390200","https://openalex.org/W2291668409","https://openalex.org/W2319420713","https://openalex.org/W2337949001","https://openalex.org/W2396033608","https://openalex.org/W2404374579","https://openalex.org/W2414774060","https://openalex.org/W4245232317","https://openalex.org/W4250522809"],"related_works":["https://openalex.org/W2044176464","https://openalex.org/W2404374579","https://openalex.org/W2583878959","https://openalex.org/W1991452746","https://openalex.org/W2017661035","https://openalex.org/W2513475865","https://openalex.org/W2074308506","https://openalex.org/W2025263020","https://openalex.org/W4394813374","https://openalex.org/W4417070040"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"widely-used":[2],"antimycotic":[3],"agent,":[4],"bis-triazole":[5],"fluconazole":[6],"(FLUCO),":[7],"is":[8,31,41,53],"able":[9],"to":[10,13,111,198],"produce":[11],"abnormalities":[12],"the":[14,44,47,75,154,164,176,201,226],"branchial":[15,29,82,94,165],"apparatus":[16,30],"(hypoplasia,":[17],"agenesis,":[18],"and":[19,34,40,62,93,133,138,153,171,187,228],"fusion)":[20],"in":[21,26,37,80,86,109,182,193,196,205,211],"postimplantation":[22],"rodent":[23],"embryos":[24,39,102,125,195],"cultured":[25],"vitro.":[27],"The":[28,160,215],"a":[32],"complex":[33],"transient":[35],"structure":[36],"vertebrate":[38],"essential":[42],"for":[43,128],"development":[45],"of":[46,123,148,163],"face":[48],"skeleton.":[49],"Branchial":[50],"arch":[51,83],"mesenchyme":[52,61,95],"formed":[54],"by":[55,223],"two":[56],"different":[57],"cellular":[58,227],"populations:":[59],"paraxial":[60],"ectomesenchyme,":[63],"which":[64],"originate":[65],"from":[66],"rhombencephalic":[67],"neural":[68],"crest":[69],"cell":[70,89,134,185,189],"(NCC)":[71],"migration.":[72,234],"We":[73],"investigated":[74,168],"possible":[76],"pathogenic":[77],"pathways":[78,208],"involved":[79],"FLUCO-related":[81],"abnormalities.":[84],"Perturbations":[85],"physiological":[87,183],"apoptosis,":[88,184],"proliferation,":[90,186],"NCC":[91,142,149,206,233],"migration":[92,143,207],"induction":[96,190],"have":[97],"been":[98],"considered.":[99],"METHODS:":[100],"Rat":[101],"(9.5-day":[103],"postcoitum;":[104],"1-3":[105],"somites)":[106],"were":[107,126,191,209],"exposed":[108],"vitro":[110],"0":[112],"or":[113,120],"500":[114],"microM":[115],"FLUCO.":[116],"After":[117],"24,":[118],"36,":[119],"48":[121],"hr":[122],"culture,":[124],"examined":[127],"apoptosis":[129],"(acridine":[130],"orange":[131],"method)":[132],"proliferation":[135],"(BrdU":[136],"incorporation":[137],"detection":[139],"method).":[140],"Rhombencephalic":[141],"was":[144,167],"analyzed":[145],"using":[146,169],"immunostaining":[147],"(using":[150,157],"anti-CRABP":[151],"antibodies)":[152],"extracellular":[155],"matrix":[156],"anti-fibronectin":[158],"antibodies).":[159],"differentiative":[161],"capability":[162],"mesenchymes":[166],"anti-endothelin":[170],"anti-endothelin-receptor":[172],"antibodies.":[173],"RESULTS:":[174],"During":[175],"whole":[177],"culture":[178],"period,":[179],"no":[180],"alterations":[181,204],"mesenchymal":[188],"observed":[192,210],"FLUCO-exposed":[194,212],"comparison":[197],"controls.":[199],"On":[200],"contrary,":[202],"severe":[203],"embryos.":[213],"CONCLUSIONS:":[214],"findings":[216],"suggest":[217],"that":[218,231],"FLUCO":[219],"produces":[220],"teratogenic":[221],"effects":[222],"interfering":[224],"with":[225],"molecular":[229],"mechanisms":[230],"control":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}