{"id":"https://openalex.org/W2000757102","doi":"https://doi.org/10.1074/jbc.272.36.22464","title":"Purification of a Fatty Acid-stimulated Protein-serine/threonine Phosphatase from Bovine Brain and Its Identification as a Homolog of Protein Phosphatase 5","display_name":"Purification of a Fatty Acid-stimulated Protein-serine/threonine Phosphatase from Bovine Brain and Its Identification as a Homolog of Protein Phosphatase 5","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2000757102","doi":"https://doi.org/10.1074/jbc.272.36.22464","mag":"2000757102","pmid":"https://pubmed.ncbi.nlm.nih.gov/9278397"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.36.22464","doi":"https://doi.org/10.1074/jbc.272.36.22464","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.36.22464","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.272.36.22464","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069467720","display_name":"Jeffrey A. SKINNER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Skinner","raw_affiliation_strings":["Biochemistry Department, Purdue University, West Lafayette, Indiana 47907, USA","From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057997995","display_name":"Christopher Sinclair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Sinclair","raw_affiliation_strings":["Biochemistry Department, Purdue University, West Lafayette, Indiana 47907","From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066225934","display_name":"Charles Romeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Romeo","raw_affiliation_strings":["Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709","From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110242570","display_name":"David L. Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Armstrong","raw_affiliation_strings":["Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709","From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005668168","display_name":"Harry Charbonneau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry Charbonneau","raw_affiliation_strings":["Biochemistry Department, Purdue University, West Lafayette, Indiana 47907","From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029095556","display_name":"Sandra S. Rossie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandra Rossie","raw_affiliation_strings":["Biochemistry Department, Purdue University, West Lafayette, Indiana 47907","From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"From the #N#\u2021Biochemistry Department, Purdue University, West Lafayette, Indiana 47907 and the #N##N#\u00a7Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709#N#","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029095556"],"corresponding_institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210095140"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.1371,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.87699002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"272","issue":"36","first_page":"22464","last_page":"22471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-5","display_name":"protein phosphatase 5","score":0.9810000061988831},{"id":"https://openalex.org/keywords/serine-threonine-protein-phosphatase","display_name":"serine/threonine phosphatase","score":0.8500000238418579},{"id":"https://openalex.org/keywords/fatty-acid-stimulation","display_name":"fatty acid stimulation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.6880000233650208},{"id":"https://openalex.org/keywords/bovine-brain","display_name":"bovine brain","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lipid-second-messengers","display_name":"lipid second messengers","score":0.6389999985694885},{"id":"https://openalex.org/keywords/protein-phosphorylation-regulation","display_name":"protein phosphorylation regulation","score":0.5429999828338623},{"id":"https://openalex.org/keywords/gst-fusion-protein","display_name":"GST fusion protein","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gh4c1-cells","display_name":"GH4C1 cells","score":0.6359999775886536},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.625},{"id":"https://openalex.org/keywords/histones","display_name":"histones","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.7346474528312683},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.7175611257553101},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.7012711763381958},{"id":"https://openalex.org/C97920573","wikidata":"https://www.wikidata.org/wiki/Q17915102","display_name":"DUSP6","level":5,"score":0.5984687209129333},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.5827345252037048},{"id":"https://openalex.org/C154779307","wikidata":"https://www.wikidata.org/wiki/Q18034943","display_name":"AKT3","level":5,"score":0.557245135307312},{"id":"https://openalex.org/C2779408958","wikidata":"https://www.wikidata.org/wiki/Q7251492","display_name":"Protein phosphatase 1","level":4,"score":0.5302735567092896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5278403759002686},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4331724941730499},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4254376292228699},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.42104262113571167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29155099391937256},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.36.22464","doi":"https://doi.org/10.1074/jbc.272.36.22464","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.36.22464","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9278397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9278397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.36.22464","doi":"https://doi.org/10.1074/jbc.272.36.22464","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.36.22464","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3415417045","display_name":"DIABETES RESEARCH AND TRAINING CENTER","funder_award_id":"P60DK020542","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4799609296","display_name":null,"funder_award_id":"DK20542","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G602298892","display_name":null,"funder_award_id":"NS31221","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7820446879","display_name":null,"funder_award_id":"CA59935","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W110124829","https://openalex.org/W1481093768","https://openalex.org/W1491031366","https://openalex.org/W1491861242","https://openalex.org/W1496561250","https://openalex.org/W1506014073","https://openalex.org/W1520176015","https://openalex.org/W1525274814","https://openalex.org/W1559427338","https://openalex.org/W1565253913","https://openalex.org/W1575679245","https://openalex.org/W1581101118","https://openalex.org/W1581414531","https://openalex.org/W1599526190","https://openalex.org/W1630411281","https://openalex.org/W1633015885","https://openalex.org/W1892570697","https://openalex.org/W1965838804","https://openalex.org/W1992511009","https://openalex.org/W1992622066","https://openalex.org/W2000152564","https://openalex.org/W2006647004","https://openalex.org/W2010005988","https://openalex.org/W2012512233","https://openalex.org/W2020401813","https://openalex.org/W2021850248","https://openalex.org/W2022443707","https://openalex.org/W2022461781","https://openalex.org/W2036030387","https://openalex.org/W2038186997","https://openalex.org/W2041705004","https://openalex.org/W2042412060","https://openalex.org/W2042850103","https://openalex.org/W2044364834","https://openalex.org/W2044575298","https://openalex.org/W2044853699","https://openalex.org/W2047835322","https://openalex.org/W2048631932","https://openalex.org/W2052596625","https://openalex.org/W2055043387","https://openalex.org/W2066483201","https://openalex.org/W2068446924","https://openalex.org/W2080438420","https://openalex.org/W2081324739","https://openalex.org/W2089640144","https://openalex.org/W2089742414","https://openalex.org/W2114471659","https://openalex.org/W2120947776","https://openalex.org/W2128635872","https://openalex.org/W2140812889"],"related_works":["https://openalex.org/W1566270827","https://openalex.org/W1582479052","https://openalex.org/W2073544379","https://openalex.org/W1801396892","https://openalex.org/W1996447642","https://openalex.org/W1593791751","https://openalex.org/W2012512233","https://openalex.org/W2032581399","https://openalex.org/W1980319258","https://openalex.org/W2033708759"],"abstract_inverted_index":{"An":[0],"arachidonic":[1,187],"acid-stimulated":[2],"Ser/Thr":[3],"phosphatase":[4,134,143,165,203],"activity":[5,27,46,74,183],"was":[6,28,135,167],"detected":[7],"in":[8,59,66,84,208],"soluble":[9],"extracts":[10],"prepared":[11],"from":[12,32,157],"rat":[13,18,163],"pituitary":[14],"clonal":[15],"GH4C1":[16],"cells,":[17],"or":[19,120,145,215],"bovine":[20,23,33,139,195],"brain,":[21],"and":[22,43,96,102,108,118,184],"heart.":[24],"The":[25,132],"enzyme":[26,179],"purified":[29,159,194],"to":[30,186,190],"homogeneity":[31],"brain":[34,196],"as":[35,137,169],"a":[36,39,44,88,146,170,181,211],"monomer":[37],"with":[38,76],"Mr":[40],"of":[41,47,50,55,62,69,87,90,124,141,153,192],"63,000":[42],"specific":[45,182],"32":[48],"nmol":[49],"Pi":[51],"released":[52],"per":[53],"min/mg":[54],"protein":[56,142,164,202],"when":[57,82],"assayed":[58,83],"the":[60,67,85,138,158,176,193],"presence":[61,86],"10":[63],"microM":[64],"phosphocasein":[65],"absence":[68],"lipid.":[70],"Arachidonic":[71],"acid":[72,110,188],"stimulated":[73,112],"4-14-fold,":[75],"half-maximal":[77],"stimulation":[78],"at":[79],"50-100":[80],"microM,":[81],"variety":[89],"phosphosubstrates":[91],"including":[92],"casein,":[93],"reduced":[94],"carboxamidomethylated":[95],"maleylated":[97],"lysozyme,":[98],"myelin":[99],"basic":[100],"protein,":[101,175],"histone.":[103],"Oleic":[104],"acid,":[105,107],"linoleic":[106],"palmitoleic":[109],"also":[111],"activity;":[113],"however,":[114],"saturated":[115],"fatty":[116,125],"acids":[117,126],"alcohol":[119],"methyl":[121],"ester":[122],"derivatives":[123],"did":[127],"not":[128],"significantly":[129],"affect":[130],"activity.":[131],"lipid-stimulated":[133],"identified":[136],"equivalent":[140],"5":[144,166,204],"closely":[147],"related":[148],"homolog":[149],"by":[150,210],"sequence":[151],"analysis":[152],"proteolytic":[154],"fragments":[155],"generated":[156],"enzyme.":[160,197],"When":[161],"recombinant":[162],"expressed":[168],"cleavable":[171],"glutathione":[172],"S-transferase":[173],"fusion":[174],"affinity-purified":[177],"thrombin-cleaved":[178],"exhibited":[180],"sensitivity":[185],"similar":[189],"those":[191],"These":[198],"results":[199],"suggest":[200],"that":[201],"may":[205],"be":[206],"regulated":[207],"vivo":[209],"lipid":[212],"second":[213],"messenger":[214],"another":[216],"endogenous":[217],"activator.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}