{"id":"https://openalex.org/W2000750275","doi":"https://doi.org/10.3109/02656739109005018","title":"Modulation of cellular glycosidase activity by hyperthermia","display_name":"Modulation of cellular glycosidase activity by hyperthermia","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2000750275","doi":"https://doi.org/10.3109/02656739109005018","mag":"2000750275","pmid":"https://pubmed.ncbi.nlm.nih.gov/1833475"},"language":"en","primary_location":{"id":"doi:10.3109/02656739109005018","doi":"https://doi.org/10.3109/02656739109005018","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02656739109005018","pdf_url":null,"source":{"id":"https://openalex.org/S107381699","display_name":"International Journal of Hyperthermia","issn_l":"0265-6736","issn":["0265-6736","1464-5157"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hyperthermia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113501910","display_name":"Kurt J. Henle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. J. Henle","raw_affiliation_strings":["Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205-5484","Departments of Medicine, Physiology/Biophysics, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205\u20135484, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205-5484","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Departments of Medicine, Physiology/Biophysics, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205\u20135484, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010384852","display_name":"Robert J. Shmookler Reis","orcid":"https://orcid.org/0000-0002-4691-0734","observed_orcids":["https://orcid.org/0000-0002-4691-0734"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Shmookler Reis","raw_affiliation_strings":["Departments of Medicine, Physiology/Biophysics, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205\u20135484, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Physiology/Biophysics, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205\u20135484, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020142407","display_name":"Charles K. Lumpkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. K. Lumpkin","raw_affiliation_strings":["Departments of Medicine, Physiology/Biophysics, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205\u20135484, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Physiology/Biophysics, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205\u20135484, USA","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79620101"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":null,"fwci":0.1321,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.38896777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"531","last_page":"537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.3452000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.3452000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.22750000655651093,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.050599999725818634,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/glycosidase-activity","display_name":"glycosidase activity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lysosomal-alpha-mannosidase","display_name":"lysosomal alpha-mannosidase","score":0.8389999866485596},{"id":"https://openalex.org/keywords/beta-galactosidase","display_name":"beta-galactosidase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/beta-hexosaminidase","display_name":"beta-hexosaminidase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":1.0},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/thermal-tolerance","display_name":"heat tolerance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/heat-resistance","display_name":"heat resistance","score":0.7549999952316284},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C196032511","wikidata":"https://www.wikidata.org/wiki/Q375795","display_name":"Glycoside hydrolase","level":3,"score":0.6164599061012268},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.574349045753479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4218432307243347},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36741703748703003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34808075428009033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34517407417297363},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3335006833076477},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3281700015068054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22687998414039612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2121783196926117}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001619","descriptor_name":"beta-N-Acetylhexosaminidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008361","descriptor_name":"Mannosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043323","descriptor_name":"alpha-Mannosidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02656739109005018","doi":"https://doi.org/10.3109/02656739109005018","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02656739109005018","pdf_url":null,"source":{"id":"https://openalex.org/S107381699","display_name":"International Journal of Hyperthermia","issn_l":"0265-6736","issn":["0265-6736","1464-5157"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hyperthermia","raw_type":"journal-article"},{"id":"pmid:1833475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1833475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G139209554","display_name":null,"funder_award_id":"CA-35689","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G391186843","display_name":null,"funder_award_id":"CA 33405","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G488780384","display_name":null,"funder_award_id":"AA07550","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6445840092","display_name":"MODULATION OF REGENERATION IN ALCOHOLIC LIVER DISEASE","funder_award_id":"5r29aa007550-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8481103033","display_name":"MODULATORS OF CELLULAR HEAT SENSITIVITY","funder_award_id":"5r01ca033405-17","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G963920045","display_name":"STEP-DOWN HEATING &X-IRRADIATION OF RIF TUMORS IN VIVO","funder_award_id":"5r01ca035689-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W43261905","https://openalex.org/W1019376971","https://openalex.org/W1551313318","https://openalex.org/W1585808192","https://openalex.org/W1601764389","https://openalex.org/W1963550534","https://openalex.org/W1969387793","https://openalex.org/W1977685486","https://openalex.org/W1988686085","https://openalex.org/W2005652338","https://openalex.org/W2016562345","https://openalex.org/W2030383415","https://openalex.org/W2035282077","https://openalex.org/W2040102608","https://openalex.org/W2041760941","https://openalex.org/W2055914511","https://openalex.org/W2057361916","https://openalex.org/W2057997147","https://openalex.org/W2066054442","https://openalex.org/W2072807237","https://openalex.org/W2078372902","https://openalex.org/W2087967399","https://openalex.org/W2116534909","https://openalex.org/W2120327661","https://openalex.org/W2202347873","https://openalex.org/W2205852957","https://openalex.org/W2316581038","https://openalex.org/W2430782794","https://openalex.org/W2460490782","https://openalex.org/W4211258199","https://openalex.org/W4233516022"],"related_works":["https://openalex.org/W1482137369","https://openalex.org/W2005652338","https://openalex.org/W2057997147","https://openalex.org/W2072807237","https://openalex.org/W2136009836","https://openalex.org/W4301239273","https://openalex.org/W2035282077","https://openalex.org/W2420763714","https://openalex.org/W1587579642","https://openalex.org/W111348958"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,10,26,92,124],"effect":[3,126],"of":[4,51,79,89,95,138],"45":[5,39,58,85,121],"degrees":[6,40,59,86,122],"C":[7,41],"hyperthermia":[8,31,78,118],"on":[9],"following":[11],"glycosidases":[12],"in":[13,35,73,114],"CHO":[14],"cells:":[15],"beta-galactosidase,":[16,66,96,105],"beta-hexosaminidase,":[17],"beta-glucuronidase":[18],"and":[19,67,142,156],"alpha-mannosidase.":[20,103],"Among":[21],"these,":[22],"lysosomal":[23,147],"alpha-mannosidase":[24],"exhibited":[25],"most":[27],"dramatic":[28,112],"response":[29,115],"to":[30,63,81,116],"with":[32,48],"an":[33],"increase":[34,44],"activity":[36,52],"immediately":[37],"after":[38,77],"hyperthermia.":[42],"The":[43,132],"was":[45,127],"linearly":[46],"dose-dependent":[47],"a":[49,111],"doubling":[50],"for":[53,102,130],"every":[54],"20":[55],"min":[56,83],"at":[57,84],"C.":[60,87],"In":[61],"contrast":[62],"alpha-mannosidase,":[64],"beta-glucuronidase,":[65],"beta-hexosaminidase":[68],"showed":[69,110],"only":[70],"minor":[71],"alterations":[72],"activity,":[74],"or":[75],"none,":[76],"10":[80],"60":[82],"Induction":[88],"thermotolerance":[90],"enhanced":[91],"heat":[93,100,154],"resistance":[94],"but":[97],"caused":[98],"increased":[99],"sensitivity":[101],"Intracellular":[104],"measured":[106],"by":[107,140,152],"histochemical":[108],"staining,":[109],"redistribution":[113],"mild":[117],"(10":[119],"min,":[120],"C);":[123],"same":[125],"not":[128],"observed":[129],"beta-glucuronidase.":[131],"data":[133],"argue":[134],"against":[135],"non-specific":[136],"activation":[137],"lysosomes":[139],"hyperthermia,":[141],"suggest":[143],"that":[144,149],"cells":[145],"contain":[146],"subpopulations":[148],"are":[150],"characterized":[151],"different":[153],"sensitivities":[155],"variable":[157],"glycosidase":[158],"contents.":[159]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
