{"id":"https://openalex.org/W2000748607","doi":"https://doi.org/10.1097/01.brs.0000186860.23078.a8","title":"Transdermal Fentanyl Versus Sustained Release Oral Morphine in Strong-Opioid Na\u00efve Patients With Chronic Low Back Pain","display_name":"Transdermal Fentanyl Versus Sustained Release Oral Morphine in Strong-Opioid Na\u00efve Patients With Chronic Low Back Pain","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W2000748607","doi":"https://doi.org/10.1097/01.brs.0000186860.23078.a8","mag":"2000748607","pmid":"https://pubmed.ncbi.nlm.nih.gov/16284584"},"language":"en","primary_location":{"id":"doi:10.1097/01.brs.0000186860.23078.a8","doi":"https://doi.org/10.1097/01.brs.0000186860.23078.a8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.brs.0000186860.23078.a8","pdf_url":null,"source":{"id":"https://openalex.org/S4026894","display_name":"Spine","issn_l":"0362-2436","issn":["0362-2436","1528-1159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000748607"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113606115","display_name":"Laurie G. Allan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161740","display_name":"St Mark's Hospital","ror":"https://ror.org/05am5g719","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800484787","https://openalex.org/I4210161740"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Laurie Allan","raw_affiliation_strings":["Northwick Park & St. Marks NHS Trust, Harrow, Middlesex, UK. laurie.allan@datacam.net","Northwick Park & St. Marks NHS Trust, Harrow, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwick Park & St. Marks NHS Trust, Harrow, Middlesex, UK. laurie.allan@datacam.net","institution_ids":[]},{"raw_affiliation_string":"Northwick Park & St. Marks NHS Trust, Harrow, Middlesex, UK","institution_ids":["https://openalex.org/I4210161740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021030323","display_name":"Ute Richarz","orcid":"https://orcid.org/0000-0001-5928-7905","observed_orcids":["https://orcid.org/0000-0001-5928-7905"]},"institutions":[{"id":"https://openalex.org/I4391767734","display_name":"Cilag (Switzerland)","ror":"https://ror.org/02fe4h741","country_code":"CH","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4210113301","https://openalex.org/I4391767734"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ute Richarz","raw_affiliation_strings":["Janssen-Cilag, Baar, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen-Cilag, Baar, Switzerland","institution_ids":["https://openalex.org/I4391767734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086106244","display_name":"Karen H Simpson","orcid":"https://orcid.org/0000-0003-0957-0512","observed_orcids":["https://orcid.org/0000-0003-0957-0512"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen Simpson","raw_affiliation_strings":["St. James' University Hospital, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. James' University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001104741","display_name":"Robert Slappendel","orcid":"https://orcid.org/0000-0002-2840-4395","observed_orcids":["https://orcid.org/0000-0002-2840-4395"]},"institutions":[{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert Slappendel","raw_affiliation_strings":["Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113606115"],"corresponding_institution_ids":["https://openalex.org/I4210161740"],"apc_list":null,"apc_paid":null,"fwci":12.7,"has_fulltext":false,"cited_by_count":161,"citation_normalized_percentile":{"value":0.99219418,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"30","issue":"22","first_page":"2484","last_page":"2490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.07509999722242355,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-fentanyl","display_name":"transdermal fentanyl","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sustained-release-morphine","display_name":"sustained-release morphine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chronic-low-back-pain","display_name":"chronic low back pain","score":0.9819999933242798},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.7720000147819519},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bowel-function","display_name":"bowel function","score":0.7570000290870667},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8299999833106995},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9634124040603638},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.8439203500747681},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7448432445526123},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.7274764180183411},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.7110722661018372},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.6400039196014404},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.605816125869751},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.4197961390018463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29946136474609375},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2047540545463562},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16710767149925232},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017116","descriptor_name":"Low Back Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018582","descriptor_name":"Sick Leave","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.brs.0000186860.23078.a8","doi":"https://doi.org/10.1097/01.brs.0000186860.23078.a8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.brs.0000186860.23078.a8","pdf_url":null,"source":{"id":"https://openalex.org/S4026894","display_name":"Spine","issn_l":"0362-2436","issn":["0362-2436","1528-1159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"journal-article"},{"id":"pmid:16284584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16284584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W162482088","https://openalex.org/W202316717","https://openalex.org/W1585714896","https://openalex.org/W1964549833","https://openalex.org/W1978228346","https://openalex.org/W1984234160","https://openalex.org/W2017605070","https://openalex.org/W2027418861","https://openalex.org/W2028685426","https://openalex.org/W2029634867","https://openalex.org/W2031238960","https://openalex.org/W2033182961","https://openalex.org/W2037377025","https://openalex.org/W2039820472","https://openalex.org/W2047560765","https://openalex.org/W2058579923","https://openalex.org/W2068619163","https://openalex.org/W2087591897","https://openalex.org/W2093112693","https://openalex.org/W2117950925","https://openalex.org/W2120092655","https://openalex.org/W2121555882","https://openalex.org/W2139935950","https://openalex.org/W2145513209","https://openalex.org/W2332159918","https://openalex.org/W2339949004","https://openalex.org/W2401046596","https://openalex.org/W2414888693","https://openalex.org/W4292806894"],"related_works":["https://openalex.org/W3021615793","https://openalex.org/W3083351287","https://openalex.org/W2350806868","https://openalex.org/W2148461943","https://openalex.org/W1987831420","https://openalex.org/W2148000461","https://openalex.org/W2068120407","https://openalex.org/W1801378514","https://openalex.org/W2086764953","https://openalex.org/W4387212204"],"abstract_inverted_index":{"STUDY":[0],"DESIGN:":[1],"Open,":[2],"randomized,":[3],"parallel":[4],"group":[5],"multicenter":[6],"study.":[7],"OBJECTIVES:":[8],"To":[9],"compare":[10],"the":[11,53],"efficacy":[12],"and":[13,19,42,109,123,130,140,179,190,195],"safety":[14],"of":[15,40,119,145,162,186,200],"transdermal":[16],"fentanyl":[17,86],"(TDF)":[18],"sustained":[20],"release":[21],"morphine":[22,95],"(SRM)":[23],"in":[24,221],"strong-opioid":[25,59,222],"na\u00efve":[26,60,223],"patients":[27,46,61,129,136,170],"with":[28,62,66,152,207],"chronic":[29],"low":[30],"back":[31],"pain":[32,107,146,164,187,201],"(CLBP).":[33],"SUMMARY":[34],"OF":[35],"BACKGROUND":[36],"DATA:":[37],"Most":[38],"studies":[39],"TDF":[41,75,139,149,178,182,194,204],"SRM":[43,77,141,196],"have":[44],"involved":[45],"already":[47],"receiving":[48,171],"strong":[49,70,215],"opioids.":[50],"This":[51,210],"is":[52],"first":[54],"large-scale":[55],"study":[56,211],"focusing":[57],"on":[58],"CLBP.":[63],"METHODS:":[64],"Adults":[65],"CLBP":[67],"requiring":[68],"regular":[69],"opioid":[71],"therapy":[72],"received":[73],"either":[74],"or":[76,91],"for":[78,169,177],"13":[79],"months.":[80],"Starting":[81],"doses":[82],"were":[83,100,126,175],"25":[84],"microg/hr":[85],"patches":[87],"every":[88,96],"72":[89],"hours":[90],"30":[92],"mg":[93],"oral":[94],"12":[97],"hours.":[98],"Doses":[99],"adjusted":[101],"according":[102],"to":[103],"response.":[104],"Participants":[105],"assessed":[106],"relief":[108,165,185],"bowel":[110],"function":[111],"using":[112],"weekly":[113],"diaries.":[114],"Other":[115,173],"assessments,":[116],"including":[117],"quality":[118],"life,":[120],"disease":[121],"progression,":[122],"side":[124],"effects,":[125],"made":[127],"by":[128],"investigators.":[131],"RESULTS:":[132],"Data":[133],"from":[134],"680":[135],"showed":[137],"that":[138,213],"provided":[142,183,197],"similar":[143,176],"levels":[144,199],"relief,":[147,202],"but":[148,181,203],"was":[150,205],"associated":[151,206],"significantly":[153],"less":[154,208],"constipation":[155,168],"than":[156],"SRM,":[157,180],"indicating":[158],"a":[159],"greater":[160,184],"likelihood":[161],"satisfactory":[163],"without":[166],"unmanageable":[167],"TDF.":[172],"ratings":[174],"at":[188,191],"rest":[189],"night.":[192],"CONCLUSIONS:":[193],"equivalent":[198],"constipation.":[209],"indicates":[212],"sustained-release":[214],"opioids":[216],"can":[217],"safely":[218],"be":[219],"used":[220],"patients.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
