{"id":"https://openalex.org/W2000747577","doi":"https://doi.org/10.1067/mcp.2002.121216","title":"Pharmacokinetics of losartan and its metabolite E\u20103174 in relation to the CYP2C9 genotype","display_name":"Pharmacokinetics of losartan and its metabolite E\u20103174 in relation to the CYP2C9 genotype","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2000747577","doi":"https://doi.org/10.1067/mcp.2002.121216","mag":"2000747577","pmid":"https://pubmed.ncbi.nlm.nih.gov/11823761"},"language":"en","primary_location":{"id":"doi:10.1067/mcp.2002.121216","doi":"https://doi.org/10.1067/mcp.2002.121216","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mcp.2002.121216","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000747577"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001596735","display_name":"\u00dcmit Ya\u015far","orcid":"https://orcid.org/0000-0001-6758-0335","observed_orcids":["https://orcid.org/0000-0001-6758-0335"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":false,"raw_author_name":"\u00dcmit Yasar","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064927721","display_name":"Cecilia Forslund\u2010Bergengren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":false,"raw_author_name":"Cecilia Forslund\u2010Bergengren","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038555087","display_name":"Gunnel Tybring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":false,"raw_author_name":"Gunnel Tybring","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043461984","display_name":"Pedro Dorado","orcid":"https://orcid.org/0000-0003-4100-721X","observed_orcids":["https://orcid.org/0000-0003-4100-721X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":false,"raw_author_name":"Pedro Dorado","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025811853","display_name":"Adri\u00e1n LLerena","orcid":"https://orcid.org/0000-0002-5663-7081","observed_orcids":["https://orcid.org/0000-0002-5663-7081","https://orcid.org/0000-0003-1076-0743"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":false,"raw_author_name":"Adri\u00e1n LLerena","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112137575","display_name":"Folke Sj\u00f6qvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":false,"raw_author_name":"Folke Sj\u00f6qvist","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017537112","display_name":"Erik Eliasson","orcid":"https://orcid.org/0000-0002-4707-4256","observed_orcids":["https://orcid.org/0000-0002-4707-4256"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":false,"raw_author_name":"Erik Eliasson","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001100678","display_name":"Marja\u2010Liisa Dahl","orcid":"https://orcid.org/0000-0002-4837-6299","observed_orcids":["https://orcid.org/0000-0002-4837-6299"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES","SE"],"is_corresponding":true,"raw_author_name":"Marja\u2010Liisa Dahl","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz","institution_ids":["https://openalex.org/I80606768"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001100678"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907","https://openalex.org/I80606768"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":7.8733,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.98350336,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"71","issue":"1","first_page":"89","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cyp2c9-polymorphism","display_name":"CYP2C9 polymorphism","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cyp2c9-3","display_name":"CYP2C9*3","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cyp2c9-1","display_name":"CYP2C9*1","score":0.765999972820282},{"id":"https://openalex.org/keywords/cyp2c9-2","display_name":"CYP2C9*2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.5099999904632568},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.5839999914169312},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.718999981880188},{"id":"https://openalex.org/keywords/genetic-variation-in-drug-metabolism","display_name":"genetic variation in drug metabolism","score":0.652999997138977},{"id":"https://openalex.org/keywords/auc-ratio","display_name":"AUC ratio","score":0.5040000081062317},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.9591357111930847},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.9049311876296997},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6804084777832031},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.676838755607605},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.612352192401886},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4974077045917511},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47632724046707153},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42752858996391296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42591091990470886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42441874742507935},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.41297098994255066},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35713234543800354},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.3109957277774811},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09252172708511353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07472467422485352},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D039181","descriptor_name":"Steroid 16-alpha-Hydroxylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065729","descriptor_name":"Cytochrome P-450 CYP2C9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1067/mcp.2002.121216","doi":"https://doi.org/10.1067/mcp.2002.121216","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mcp.2002.121216","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:11823761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11823761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998069164","https://openalex.org/W2071240356","https://openalex.org/W2941542070","https://openalex.org/W3177189777","https://openalex.org/W2094692338","https://openalex.org/W1997933847","https://openalex.org/W2025337905","https://openalex.org/W2079912450","https://openalex.org/W1906202901","https://openalex.org/W3123661481"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM:":[2],"Losartan":[3,45],"is":[4],"metabolized":[5],"by":[6,50],"polymorphic":[7],"CYP2C9":[8,26,43,302],"to":[9,14,24,37,59,149,191,253,291,312],"E-3174.":[10],"Our":[11],"aim":[12],"was":[13,35,96,155,205,251],"evaluate":[15],"the":[16,25,102,115,133,139,144,150,158,161,168,180,189,197,202,211,226,241,275,279,286],"pharmacokinetics":[17],"of":[18,33,85,94,138,199,259],"losartan":[19,34,66,141],"and":[20,46,54,67,107,120,126,165,170,175,216,234,270,274,281],"E-3174":[21,47,68,95,152,260],"in":[22,52,71,101,129,157,167,208,223,238,268,289,306],"relation":[23],"genotype.":[27,135],"METHODS:":[28],"A":[29],"50-mg":[30],"oral":[31,83],"dose":[32,84],"given":[36],"22":[38],"Swedish":[39],"volunteers":[40],"with":[41,114,132,160,179,188,210,225,240,256],"different":[42],"genotypes.":[44],"were":[48,69],"analyzed":[49,70],"HPLC":[51],"plasma":[53,92,145,184,269,280],"urine":[55,73,271,282,293],"samples":[56,74],"collected":[57,75],"up":[58],"24":[60],"hours":[61],"after":[62,80],"drug":[63],"intake.":[64],"Furthermore,":[65],"8-hour":[72,192,292],"from":[76,261],"17":[77],"Spanish":[78],"subjects":[79,209,239],"a":[81,298],"single":[82],"25":[86],"mg":[87],"losartan.":[88,262],"RESULTS:":[89],"The":[90,136,183,248,263],"maximum":[91],"concentration":[93],"significantly":[97,187,206],"(P":[98],"<.05)":[99],"lower":[100],"CYP2C9*1/*3":[103,169,212],"(n":[104,109,117,122,213,218,229,244],"=":[105,110,118,123,214,219,230,245],"5)":[106],"CYP2C9*2/*3":[108],"4)":[111,220],"groups":[112,125,172],"compared":[113,178],"CYP2C9*1/*1":[116,181,227],"6)":[119],"CYP2C9*1/*2":[121],"3)":[124],"extremely":[127],"low":[128],"1":[130],"subject":[131,159],"CYP2C9*3/*3":[134,162,242],"ratio":[137,204,288],"total":[140,151,198],"area":[142],"under":[143],"concentration-time":[146],"curve":[147],"(AUC)":[148],"AUC":[153],"(AUC(losartan)/AUC(E-3174))":[154],"higher":[156,207,237],"genotype":[163,228,243],"(30-fold)":[164],"also":[166],"*2/*3":[171,217],"(approximately":[173],"2-":[174],"3-fold,":[176],"respectively)":[177],"group.":[182],"ratios":[185,273,283],"correlated":[186],"0-":[190,290],"urinary":[193,203],"losartan/E-3174":[194,272,287],"ratios.":[195],"Among":[196],"39":[200],"subjects,":[201],"10)":[215],"genotypes":[221,267],"than":[222],"those":[224],"11;":[231],"P":[232],"<.01)":[233],"approximately":[235],"40-fold":[236],"3).":[246],"CONCLUSION:":[247],"CYP2C9*3":[249],"allele":[250],"shown":[252],"be":[254,310],"associated":[255],"decreased":[257],"formation":[258],"significant":[264],"differences":[265],"between":[266,278],"good":[276],"correlation":[277],"suggest":[284],"that":[285],"specimens":[294],"may":[295],"serve":[296],"as":[297],"phenotyping":[299],"assay":[300],"for":[301],"activity.":[303],"Further":[304],"studies":[305],"larger":[307],"populations":[308],"will":[309],"required":[311],"establish":[313],"this.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
