{"id":"https://openalex.org/W2000742401","doi":"https://doi.org/10.1002/ijc.10852","title":"Inactivation of the DNA repair gene O 6 \u2010methylguanine\u2010DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B 1 \u2010DNA adducts and p53 mutation in hepatocellular carcinoma","display_name":"Inactivation of the DNA repair gene O 6 \u2010methylguanine\u2010DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B 1 \u2010DNA adducts and p53 mutation in hepatocellular carcinoma","publication_year":2002,"publication_date":"2002-11-21","ids":{"openalex":"https://openalex.org/W2000742401","doi":"https://doi.org/10.1002/ijc.10852","mag":"2000742401","pmid":"https://pubmed.ncbi.nlm.nih.gov/12478658"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.10852","doi":"https://doi.org/10.1002/ijc.10852","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.10852","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101439605","display_name":"Yu\u2010Jing Zhang","orcid":"https://orcid.org/0000-0001-7236-2375","observed_orcids":["https://orcid.org/0000-0001-7236-2375"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu\u2010Jing Zhang","raw_affiliation_strings":["Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health, Columbia University, 700 West 168th Street, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health, Columbia University, 700 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402008","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-1519-4894","observed_orcids":["https://orcid.org/0000-0002-1519-4894","https://orcid.org/0000-0002-5159-3382","https://orcid.org/0000-0003-1962-5329"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003374278","display_name":"Habibul Ahsan","orcid":"https://orcid.org/0000-0001-9808-377X","observed_orcids":["https://orcid.org/0000-0001-9808-377X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habibul Ahsan","raw_affiliation_strings":["Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000745956","display_name":"Ruth M. Lunn","orcid":"https://orcid.org/0000-0002-9605-7137","observed_orcids":["https://orcid.org/0000-0002-9605-7137"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth M. Lunn","raw_affiliation_strings":["National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA","National Institute of Environmental Health Sciences , Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I4210095140"]},{"raw_affiliation_string":"National Institute of Environmental Health Sciences , Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017113195","display_name":"Po\u2010Huang Lee","orcid":"https://orcid.org/0000-0001-5831-035X","observed_orcids":["https://orcid.org/0000-0001-5831-035X"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po\u2010Huang Lee","raw_affiliation_strings":["Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan","[Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"[Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan]","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672520","display_name":"Chien\u2010Jen Chen","orcid":"https://orcid.org/0000-0002-6996-9069","observed_orcids":["https://orcid.org/0000-0002-6996-9069","https://orcid.org/0000-0002-5799-6705"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien\u2010Jen Chen","raw_affiliation_strings":["Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084377118","display_name":"Regina M. Santella","orcid":"https://orcid.org/0000-0003-0823-6221","observed_orcids":["https://orcid.org/0000-0003-0823-6221"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Regina M. Santella","raw_affiliation_strings":["","Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084377118"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.864,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.69901655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"103","issue":"4","first_page":"440","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o6-methylguanine-dna-methyltransferase","display_name":"O6-methylguanine-DNA methyltransferase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mgmt-promoter-hypermethylation","display_name":"MGMT promoter hypermethylation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":0.968999981880188},{"id":"https://openalex.org/keywords/aflatoxin-dna-adducts","display_name":"aflatoxin-DNA adducts","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/environmental-carcinogen-exposure","display_name":"environmental carcinogen exposure","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.768661618232727},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.7076566815376282},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7046539783477783},{"id":"https://openalex.org/C2779527866","wikidata":"https://www.wikidata.org/wiki/Q21118735","display_name":"O-6-methylguanine-DNA methyltransferase","level":5,"score":0.6959742307662964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6079593896865845},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5927457809448242},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5563649535179138},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.5370560884475708},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5319238901138306},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5197591185569763},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4724971354007721},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4332689940929413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4283067286014557},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4154110550880432},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26765990257263184},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2268252968788147}],"mesh":[{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.10852","doi":"https://doi.org/10.1002/ijc.10852","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.10852","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:12478658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12478658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3916197029","display_name":"Biological Markers of Aflatoxin Exposure and Methylation","funder_award_id":"R01ES005116","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G478155557","display_name":null,"funder_award_id":"ES-05116","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G685765964","display_name":null,"funder_award_id":"P30-ES09089","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000920621","display_name":"Center for Environmental Health in Northern Manhattan","funder_award_id":"P30ES009089","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1491259047","https://openalex.org/W1520098239","https://openalex.org/W1537479709","https://openalex.org/W1552528612","https://openalex.org/W1570006151","https://openalex.org/W1588444780","https://openalex.org/W1651029566","https://openalex.org/W1869160040","https://openalex.org/W1969052874","https://openalex.org/W1991791332","https://openalex.org/W1994465394","https://openalex.org/W1996344481","https://openalex.org/W2001561538","https://openalex.org/W2012766683","https://openalex.org/W2017515560","https://openalex.org/W2028834400","https://openalex.org/W2043107288","https://openalex.org/W2073388314","https://openalex.org/W2077670941","https://openalex.org/W2098140018","https://openalex.org/W2100836767","https://openalex.org/W2104633297","https://openalex.org/W2105074040","https://openalex.org/W2106623591","https://openalex.org/W2106816824","https://openalex.org/W2111960505","https://openalex.org/W2119859601","https://openalex.org/W2125949119","https://openalex.org/W2129682511","https://openalex.org/W2137180582","https://openalex.org/W2141521501","https://openalex.org/W2156882408","https://openalex.org/W2157866949","https://openalex.org/W2158677075","https://openalex.org/W4235858387","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2351942949","https://openalex.org/W2165434334","https://openalex.org/W2028791115","https://openalex.org/W1998747830","https://openalex.org/W1978530765","https://openalex.org/W2012630781","https://openalex.org/W2372178128","https://openalex.org/W3150980020","https://openalex.org/W2011512314","https://openalex.org/W2465225217"],"abstract_inverted_index":{"O(6)-methylguanine-DNA":[0],"methyltransferase":[1],"(MGMT)":[2],"is":[3,22],"a":[4],"repair":[5],"protein":[6],"that":[7,181],"specifically":[8],"removes":[9],"promutagenic":[10],"alkyl":[11],"groups":[12],"from":[13],"the":[14,39,191],"O(6)":[15],"position":[16],"of":[17,44,62,85,91,98,125,146,184,193,206,214],"guanine":[18],"in":[19,28,60,72,149,190,209,217],"DNA.":[20],"MGMT":[21,40,80,99,140,185],"transcriptionally":[23],"silenced":[24],"by":[25,82],"promoter":[26,41,141],"hypermethylation":[27,93,142,218],"several":[29],"human":[30],"cancers.":[31],"Methylation-specific":[32],"PCR":[33],"(MSP)":[34],"was":[35,58,69,94,130,137,162],"used":[36],"to":[37,115,197,203],"analyze":[38],"methylation":[42,104,166,205],"status":[43,105,124,170],"83":[45,63],"hepatocellular":[46],"carcinomas":[47],"(HCC)":[48],"and":[49,55,106,109,123,143,167,195],"2":[50],"HCC":[51,65,74,86,194],"cell":[52,75],"lines":[53],"(HepG2":[54],"Hep3B).":[56],"Hypermethylation":[57],"detected":[59],"32":[61],"(39%)":[64],"tissues,":[66],"but":[67],"it":[68],"not":[70],"found":[71,138,164],"either":[73],"line.":[76],"We":[77],"also":[78,131,163],"analyzed":[79],"expression":[81],"immunohistochemical":[83],"analysis":[84],"tissue":[87],"samples.":[88],"The":[89,101,212],"presence":[90],"aberrant":[92],"associated":[95],"with":[96],"loss":[97],"protein.":[100],"relationship":[102],"between":[103,139,165],"risk":[107],"factors":[108],"tumor":[110,126,150],"markers":[111],"including":[112],"environmental":[113,198],"exposure":[114,196],"aflatoxin":[116],"B(1)":[117],"(AFB(1)),":[118],"measured":[119],"as":[120],"DNA":[121],"adducts,":[122],"suppressor":[127],"gene":[128],"p53":[129,168],"investigated.":[132],"A":[133,159],"statistically":[134],"significant":[135,160],"association":[136,161],"high":[144],"level":[145],"AFB(1)-DNA":[147],"adducts":[148],"tissues":[151],"(OR":[152,171],"=":[153,157,172,176],"5.05,":[154],"95%":[155,174],"CI":[156,175],"1.29-19.73).":[158],"mutation":[169],"2.97,":[173],"1.09-8.11).":[177],"These":[178],"results":[179],"suggest":[180],"epigenetic":[182],"inactivation":[183],"plays":[186],"an":[187],"important":[188],"role":[189,213],"development":[192],"carcinogens":[199,216],"may":[200],"be":[201],"related":[202],"altered":[204],"genes":[207],"involved":[208],"cancer":[210],"development.":[211],"chemical":[215],"needs":[219],"further":[220],"investigation.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
