{"id":"https://openalex.org/W2000742321","doi":"https://doi.org/10.3233/jad-2010-100564","title":"Mitochondria-Targeted Antioxidants Protect Against Amyloid-\u03b2 Toxicity in Alzheimer's Disease Neurons","display_name":"Mitochondria-Targeted Antioxidants Protect Against Amyloid-\u03b2 Toxicity in Alzheimer's Disease Neurons","publication_year":2010,"publication_date":"2010-06-03","ids":{"openalex":"https://openalex.org/W2000742321","doi":"https://doi.org/10.3233/jad-2010-100564","mag":"2000742321","pmid":"https://pubmed.ncbi.nlm.nih.gov/20463406","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072711"},"language":"en","primary_location":{"id":"doi:10.3233/jad-2010-100564","doi":"https://doi.org/10.3233/jad-2010-100564","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-2010-100564","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad100564?id=journal-of-alzheimers-disease%2Fjad100564","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad100564?id=journal-of-alzheimers-disease%2Fjad100564","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039583864","display_name":"Maria Ma\u0144czak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Manczak","raw_affiliation_strings":["Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110021177","display_name":"Peizhong Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peizhong Mao","raw_affiliation_strings":["Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033952080","display_name":"Markus J. Calkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus J. Calkins","raw_affiliation_strings":["Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109058258","display_name":"Anda M. Cornea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anda Cornea","raw_affiliation_strings":["Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032668464","display_name":"Arubala P. Reddy","orcid":"https://orcid.org/0000-0003-0452-9553","observed_orcids":["https://orcid.org/0000-0003-0452-9553"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arubala P. Reddy","raw_affiliation_strings":["Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062511010","display_name":"Michael P. Murphy","orcid":"https://orcid.org/0000-0003-1115-9618","observed_orcids":["https://orcid.org/0000-0003-1115-9618"]},"institutions":[{"id":"https://openalex.org/I79266365","display_name":"MRC Mitochondrial Biology Unit","ror":"https://ror.org/01vdt8f48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I79266365","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael P. Murphy","raw_affiliation_strings":["Medical Research Council, Mitochondrial Biology Unit, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council, Mitochondrial Biology Unit, Cambridge, UK","institution_ids":["https://openalex.org/I79266365","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087249159","display_name":"Hazel H. Szeto","orcid":"https://orcid.org/0000-0003-4021-5076","observed_orcids":["https://orcid.org/0000-0003-4021-5076"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hazel H. Szeto","raw_affiliation_strings":["Department of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053120757","display_name":"Byung S. Park","orcid":"https://orcid.org/0000-0003-3516-7516","observed_orcids":["https://orcid.org/0000-0003-3516-7516"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Byung Park","raw_affiliation_strings":["Byung Park, Division of Biostatistics, Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Byung Park, Division of Biostatistics, Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084673116","display_name":"P. Hemachandra Reddy","orcid":"https://orcid.org/0000-0002-9560-9948","observed_orcids":["https://orcid.org/0000-0002-9560-9948"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Hemachandra Reddy","raw_affiliation_strings":["Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, USA","Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.154,"has_fulltext":true,"cited_by_count":473,"citation_normalized_percentile":{"value":0.99325236,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"20","issue":"s2","first_page":"S609","last_page":"S631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8230000138282776},{"id":"https://openalex.org/keywords/amyloid-beta-toxicity","display_name":"amyloid-beta toxicity","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.8207582235336304},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7885995507240295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5572912693023682},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.5285640954971313},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4672785997390747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.464967280626297},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.44986534118652344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4057835340499878},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.365772545337677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2864909768104553},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1748959720134735},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.17224624752998352}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054464","descriptor_name":"Peroxiredoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054464","descriptor_name":"Peroxiredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-2010-100564","doi":"https://doi.org/10.3233/jad-2010-100564","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-2010-100564","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad100564?id=journal-of-alzheimers-disease%2Fjad100564","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:20463406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20463406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2083786","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3072711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072711","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3233/jad-2010-100564","doi":"https://doi.org/10.3233/jad-2010-100564","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-2010-100564","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad100564?id=journal-of-alzheimers-disease%2Fjad100564","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3160859834","display_name":"SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER","funder_award_id":"P51RR000163","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6383827583","display_name":"Synapse function in a mouse model of Alzheimer's disease","funder_award_id":"R03AG026051","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6563441761","display_name":"Abeta Toxicity, ROS and Mitochondrial Dysfunction in Aging/Alzheimer's Disease","funder_award_id":"R01AG028072","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7524207001","display_name":"REPRODUCTIVE STEROIDS AND EXPERIMENTAL STROKE","funder_award_id":"K01RR000163","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G834483484","display_name":null,"funder_award_id":"RR-00163.","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000079540","display_name":null,"funder_award_id":"RR 00163","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000742321.pdf","grobid_xml":"https://content.openalex.org/works/W2000742321.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W103899784","https://openalex.org/W1501371332","https://openalex.org/W1503983308","https://openalex.org/W1585782290","https://openalex.org/W1602771322","https://openalex.org/W1643772655","https://openalex.org/W1721269439","https://openalex.org/W1968257316","https://openalex.org/W1972083248","https://openalex.org/W1980989830","https://openalex.org/W1981614332","https://openalex.org/W1989167108","https://openalex.org/W1990752558","https://openalex.org/W1998949081","https://openalex.org/W2001093038","https://openalex.org/W2001210466","https://openalex.org/W2002444341","https://openalex.org/W2006007524","https://openalex.org/W2006569015","https://openalex.org/W2007047564","https://openalex.org/W2010490262","https://openalex.org/W2014288658","https://openalex.org/W2018427433","https://openalex.org/W2019275855","https://openalex.org/W2037640340","https://openalex.org/W2045085957","https://openalex.org/W2050860441","https://openalex.org/W2057194478","https://openalex.org/W2075584603","https://openalex.org/W2076241970","https://openalex.org/W2080290961","https://openalex.org/W2082966118","https://openalex.org/W2087403995","https://openalex.org/W2089141103","https://openalex.org/W2089616240","https://openalex.org/W2094869059","https://openalex.org/W2098548022","https://openalex.org/W2099485083","https://openalex.org/W2103024032","https://openalex.org/W2103807862","https://openalex.org/W2106920456","https://openalex.org/W2113002082","https://openalex.org/W2114918609","https://openalex.org/W2116349390","https://openalex.org/W2119983609","https://openalex.org/W2120701804","https://openalex.org/W2120901401","https://openalex.org/W2121760835","https://openalex.org/W2122922916","https://openalex.org/W2124955411","https://openalex.org/W2133324187","https://openalex.org/W2139206850","https://openalex.org/W2139867864","https://openalex.org/W2140014506","https://openalex.org/W2141282621","https://openalex.org/W2141789735","https://openalex.org/W2143582172","https://openalex.org/W2144127904","https://openalex.org/W2145549455","https://openalex.org/W2145558487","https://openalex.org/W2152165298","https://openalex.org/W2155377149","https://openalex.org/W2156326104","https://openalex.org/W2158994354","https://openalex.org/W2163757074","https://openalex.org/W2165427528","https://openalex.org/W2165474925","https://openalex.org/W2169152986","https://openalex.org/W2912533018","https://openalex.org/W4235723196","https://openalex.org/W4249176812"],"related_works":["https://openalex.org/W2009415753","https://openalex.org/W7161541404","https://openalex.org/W2048630929","https://openalex.org/W2495167880","https://openalex.org/W1988664434","https://openalex.org/W2055206622","https://openalex.org/W298549210","https://openalex.org/W2486567499","https://openalex.org/W2106662739","https://openalex.org/W7097866263"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,10,30,92,99,106,110,122,170,236],"our":[3],"study":[4,235],"was":[5,140,181,190,211,218],"to":[6,243],"investigate":[7],"the":[8,11,18,42,86,111,234],"effects":[9],"mitochondria-targeted":[12],"antioxidants,":[13],"MitoQ":[14,206,225,237],"and":[15,17,34,48,54,61,63,73,75,96,102,161,163,172,178,187,207,214,226,238],"SS31,":[16,72,160,208],"anti-aging":[19],"agent":[20],"resveratrol":[21],"on":[22,35],"neurons":[23,195],"from":[24,196],"a":[25,118],"mouse":[26,36],"model":[27],"(Tg2576":[28],"line)":[29],"Alzheimer's":[31],"disease":[32],"(AD)":[33],"neuroblastoma":[37],"(N2a)":[38],"cells":[39,68,82,113,156],"incubated":[40,77,84,114,165],"with":[41,70,78,85,115,158,166,205,246],"amyloid-beta":[43,197],"(Abeta)":[44],"peptide.":[45],"Using":[46],"electron":[47],"confocal":[49],"microscopy,":[50],"gene":[51],"expression":[52,98,105,169,217],"analysis,":[53],"biochemical":[55],"methods,":[56],"we":[57,88],"studied":[58],"mitochondrial":[59,93,173,179],"structure":[60],"function":[62,133,180],"neurite":[64,151,188,209],"outgrowth":[65,139,189,210],"in":[66,136,143,154],"N2a":[67,81,112,145,155],"treated":[69,157,204],"MitoQ,":[71,159],"resveratrol,":[74,162],"then":[76,164],"Abeta.":[79],"In":[80,193],"only":[83],"Abeta,":[87,167],"found":[89],"increased":[90,120,213],"expressions":[91],"fission":[94],"genes":[95,101,175],"decreased":[97,104,142],"fusion":[100],"also":[103],"peroxiredoxins.":[107],"Electron":[108],"microscopy":[109],"Abeta":[116,126,149,229],"revealed":[117,131],"significantly":[119,141,191,212,219],"number":[121],"mitochondria,":[123],"indicating":[124,147],"that":[125,132,148,202,224],"fragments":[127],"mitochondria.":[128,137],"Biochemical":[129],"analysis":[130],"is":[134],"defective":[135],"Neurite":[138],"Abeta-incubated":[144],"cells,":[146],"affects":[150],"outgrowth.":[152],"However,":[153],"abnormal":[168],"peroxiredoxins":[171],"structural":[174],"were":[176,185,203],"prevented":[177],"normal;":[182],"intact":[183],"mitochondria":[184],"present":[186],"increased.":[192],"primary":[194],"precursor":[198],"protein":[199],"transgenic":[200],"mice":[201],"cyclophilin":[215],"D":[216],"decreased.":[220],"These":[221],"findings":[222],"suggest":[223],"SS31":[227,239],"prevent":[228],"toxicity,":[230],"which":[231],"would":[232],"warrant":[233],"as":[240],"potential":[241],"drugs":[242],"treat":[244],"patients":[245],"AD.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":36},{"year":2017,"cited_by_count":37},{"year":2016,"cited_by_count":35},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":40}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
