{"id":"https://openalex.org/W2000732941","doi":"https://doi.org/10.1002/jat.2550080111","title":"An experimental study on the respiratory toxicity of isopropyl alcohol","display_name":"An experimental study on the respiratory toxicity of isopropyl alcohol","publication_year":1988,"publication_date":"1988-02-01","ids":{"openalex":"https://openalex.org/W2000732941","doi":"https://doi.org/10.1002/jat.2550080111","mag":"2000732941","pmid":"https://pubmed.ncbi.nlm.nih.gov/3356866"},"language":"en","primary_location":{"id":"doi:10.1002/jat.2550080111","doi":"https://doi.org/10.1002/jat.2550080111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.2550080111","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111648943","display_name":"Yoshihiro Ohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshihiro Ohashi","raw_affiliation_strings":["Department of Otolaryngology, Osaka City, University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City, University Medical School, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110343680","display_name":"Yoshiaki Nakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I4210166029","display_name":"Osaka City University Hospital","ror":"https://ror.org/05mxean80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166029"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Nakai","raw_affiliation_strings":["Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I4210166029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000314358","display_name":"Hiroshi Ikeoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I4210166029","display_name":"Osaka City University Hospital","ror":"https://ror.org/05mxean80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166029"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ikeoka","raw_affiliation_strings":["Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I4210166029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025960376","display_name":"Hiroyuki Koshimo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I4210166029","display_name":"Osaka City University Hospital","ror":"https://ror.org/05mxean80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166029"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Koshimo","raw_affiliation_strings":["Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I4210166029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013484241","display_name":"Yusuke Esaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I4210166029","display_name":"Osaka City University Hospital","ror":"https://ror.org/05mxean80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166029"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Esaki","raw_affiliation_strings":["Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I4210166029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109282551","display_name":"Shun'ichi Horiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shu\u0144ichi Horiguchi","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112901217","display_name":"Keiko Teramoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Teramoto","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079129601","display_name":"Hiroyuki Nakaseko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Nakaseko","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Osaka City University Medical School, Asahimachi 1\u20135\u20137, Abenoku, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111648943"],"corresponding_institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":0.146,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.42287505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":"1","first_page":"67","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.3822999894618988,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.3822999894618988,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.1339000016450882,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13315","display_name":"Occupational Health and Safety in Workplaces","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isopropanol","display_name":"isopropanol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/respiratory-toxicity","display_name":"respiratory toxicity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ciliary-activity","display_name":"ciliary activity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/nasal-mucosa","display_name":"nasal mucosa","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tracheal-mucosa","display_name":"tracheal mucosa","score":0.9629999995231628},{"id":"https://openalex.org/keywords/epithelial-degeneration","display_name":"epithelial degeneration","score":0.7639999985694885},{"id":"https://openalex.org/keywords/inhalation-exposure","display_name":"inhalation exposure","score":0.7929999828338623},{"id":"https://openalex.org/keywords/vapor-exposure","display_name":"vapor exposure","score":0.460999995470047},{"id":"https://openalex.org/keywords/acgih","display_name":"ACGIH","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.7488428354263306},{"id":"https://openalex.org/C2775850501","wikidata":"https://www.wikidata.org/wiki/Q16392","display_name":"Isopropyl alcohol","level":2,"score":0.6140970587730408},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5978232026100159},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.552914559841156},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5200079083442688},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5138661861419678},{"id":"https://openalex.org/C59377437","wikidata":"https://www.wikidata.org/wiki/Q515471","display_name":"Mucous membrane of nose","level":2,"score":0.4991915225982666},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4381629526615143},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.4243975281715393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4126240015029907},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4121983051300049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37707751989364624},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3316936492919922},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3287604749202728},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25719892978668213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22951948642730713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20328909158706665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08640119433403015},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0711597204208374}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000433","descriptor_name":"1-Propanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012140","descriptor_name":"Respiratory Tract Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012140","descriptor_name":"Respiratory Tract Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jat.2550080111","doi":"https://doi.org/10.1002/jat.2550080111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.2550080111","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:3356866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3356866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W7067540","https://openalex.org/W97550521","https://openalex.org/W175839812","https://openalex.org/W349625481","https://openalex.org/W1986273967","https://openalex.org/W2008282176","https://openalex.org/W2013810401","https://openalex.org/W2016598766","https://openalex.org/W2073171529","https://openalex.org/W2396179536"],"related_works":["https://openalex.org/W2089877911","https://openalex.org/W1974759617","https://openalex.org/W359221270","https://openalex.org/W1981093578","https://openalex.org/W2527154954","https://openalex.org/W413844443","https://openalex.org/W2324348092","https://openalex.org/W2589877681","https://openalex.org/W2074015054","https://openalex.org/W7101164430"],"abstract_inverted_index":{"Guinea-pigs":[0],"were":[1,19,34,114],"exposed":[2],"to":[3,59,84],"400":[4,60,85],"ppm":[5,8,63,86],"or":[6,61],"5500":[7,62],"of":[9,29,40,64,69,87,94,102,130],"isopropyl":[10],"alcohol":[11],"(IPA)":[12],"for":[13],"24":[14],"successive":[15],"hours,":[16],"and":[17,32,43,49,73,97,111],"they":[18],"killed":[20],"immediately":[21],"after":[22],"the":[23,30,38,41,70,92,95,99,103,128,131],"exposure":[24,58,83,105],"period.":[25],"The":[26,53],"ciliary":[27,71,100],"activities":[28],"nose":[31,42,96],"trachea":[33,44],"examined.":[35],"In":[36],"addition,":[37],"epithelium":[39],"was":[45,107],"observed":[46],"by":[47,136],"scanning":[48],"transmission":[50],"electron":[51],"microscopy.":[52],"present":[54],"study":[55,80,126],"showed":[56],"that":[57,82],"IPA":[65,88,133],"vapor":[66,89],"caused":[67],"deterioration":[68],"activity":[72,101],"also":[74],"some":[75],"pathological":[76],"changes.":[77],"Although":[78],"our":[79,125],"revealed":[81],"can":[90],"affect":[91],"mucosa":[93],"trachea,":[98],"400-ppm":[104],"group":[106],"not":[108],"too":[109],"poor":[110],"morphological":[112],"changes":[113],"rather":[115],"mild.":[116],"Recovery":[117],"from":[118],"such":[119],"degeneration":[120],"might":[121],"be":[122],"rapid.":[123],"Therefore,":[124],"supports":[127],"justification":[129],"allowable":[132],"level":[134],"recommended":[135],"ACGIH.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
