{"id":"https://openalex.org/W2000731922","doi":"https://doi.org/10.1186/1471-2164-10-64","title":"Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach","display_name":"Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach","publication_year":2009,"publication_date":"2009-02-05","ids":{"openalex":"https://openalex.org/W2000731922","doi":"https://doi.org/10.1186/1471-2164-10-64","mag":"2000731922","pmid":"https://pubmed.ncbi.nlm.nih.gov/19196461","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2660370"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-10-64","doi":"https://doi.org/10.1186/1471-2164-10-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-10-64","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-10-64.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-10-64.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033480673","display_name":"Hongbo Chen","orcid":"https://orcid.org/0000-0003-4341-5698","observed_orcids":["https://orcid.org/0000-0003-4341-5698"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbo Chen","raw_affiliation_strings":["Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, PR China. rose060417@yahoo.com.cn","Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, PR China. rose060417@yahoo.com.cn","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044246694","display_name":"Changchun Li","orcid":"https://orcid.org/0000-0002-8030-8632","observed_orcids":["https://orcid.org/0000-0002-8030-8632"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changchun Li","raw_affiliation_strings":["Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049760230","display_name":"Ming-Di Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingdi Fang","raw_affiliation_strings":["Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046658931","display_name":"Mengjin Zhu","orcid":"https://orcid.org/0000-0001-8931-5022","observed_orcids":["https://orcid.org/0000-0001-8931-5022"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengjin Zhu","raw_affiliation_strings":["Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056771708","display_name":"Xinyun Li","orcid":"https://orcid.org/0000-0002-7943-1713","observed_orcids":["https://orcid.org/0000-0002-7943-1713"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyun Li","raw_affiliation_strings":["Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021897788","display_name":"Rui Zhou","orcid":"https://orcid.org/0000-0002-7903-9965","observed_orcids":["https://orcid.org/0000-0002-7903-9965"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]},{"id":"https://openalex.org/I4391768000","display_name":"State Key Laboratory of Agricultural Microbiology","ror":"https://ror.org/003hwx626","country_code":"CN","type":"facility","lineage":["https://openalex.org/I204823248","https://openalex.org/I4391768000"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zhou","raw_affiliation_strings":["Division of Animal Infectious Disease, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China","Division of Animal Infectious Disease, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Animal Infectious Disease, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China","institution_ids":["https://openalex.org/I204823248","https://openalex.org/I4391768000"]},{"raw_affiliation_string":"Division of Animal Infectious Disease, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, PR China","institution_ids":["https://openalex.org/I204823248","https://openalex.org/I4391768000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396632","display_name":"Kui Li","orcid":"https://orcid.org/0000-0002-5686-3898","observed_orcids":["https://orcid.org/0000-0002-5686-3898","https://orcid.org/0009-0007-0869-8529"]},"institutions":[{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210149494","display_name":"Institute of Animal Sciences","ror":"https://ror.org/04tcthy91","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210149494","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kui Li","raw_affiliation_strings":["Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100094, PR China","Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100094, PR China","institution_ids":["https://openalex.org/I4210138501","https://openalex.org/I4210149494"]},{"raw_affiliation_string":"Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, PR China","institution_ids":["https://openalex.org/I4210138501","https://openalex.org/I4210149494"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065223172","display_name":"Shuhong Zhao","orcid":"https://orcid.org/0000-0002-3997-2320","observed_orcids":["https://orcid.org/0000-0002-3997-2320"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuhong Zhao","raw_affiliation_strings":["Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, PR China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065223172"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":5.7637,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.96347956,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"64","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.21940000355243683,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaesserella-parasuis","display_name":"Haemophilus parasuis","score":1.0},{"id":"https://openalex.org/keywords/glasser-s-disease","display_name":"Gl\u00e4sser's disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/porcine-spleen","display_name":"porcine spleen","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7210000157356262},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8579999804496765},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.8479999899864197},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.8690000176429749},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":1.0},{"id":"https://openalex.org/keywords/s100a12","display_name":"S100A12","score":0.9909999966621399},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.7710000276565552},{"id":"https://openalex.org/keywords/antigen-processing-and-presentation","display_name":"antigen processing and presentation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/disease-resistance","display_name":"disease resistance","score":0.5019999742507935},{"id":"https://openalex.org/keywords/pk-15-cells","display_name":"PK-15 cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9330000281333923},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8644225597381592},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.610206663608551},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5738894939422607},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5345349311828613},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5043667554855347},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5036079287528992},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.48182716965675354},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.4536241888999939},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4235655963420868},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3898625075817108},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3379557132720947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32035186886787415}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044137","descriptor_name":"Haemophilus parasuis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2164-10-64","doi":"https://doi.org/10.1186/1471-2164-10-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-10-64","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-10-64.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:19196461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19196461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2660370","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2660370/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.8340","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.8340","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1471-2164-10-64.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:acfbb7f0a8114211b3710579e4f359db","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/acfbb7f0a8114211b3710579e4f359db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics, Vol 10, Iss 1, p 64 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-10-64","doi":"https://doi.org/10.1186/1471-2164-10-64","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-10-64","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-10-64.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8051011635","display_name":"\u732a\u514d\u75ab\u5e94\u7b54\u76f8\u5173\u57fa\u56e0\u7684eQTL\u4f5c\u56fe\u3001\u529f\u80fd\u9274\u5b9a\u53ca\u7528\u4e8e\u4f18\u8d28\u732a\u57f9\u80b2\u7684\u82e5\u5e72\u5173\u952e\u95ee\u9898\u7814\u7a76","funder_award_id":"U0631005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8631498578","display_name":null,"funder_award_id":"2006CB504402","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000731922.pdf","grobid_xml":"https://content.openalex.org/works/W2000731922.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1933606","https://openalex.org/W112407991","https://openalex.org/W183870407","https://openalex.org/W1522366797","https://openalex.org/W1539459415","https://openalex.org/W1555052410","https://openalex.org/W1565460899","https://openalex.org/W1567895031","https://openalex.org/W1584837735","https://openalex.org/W1662493683","https://openalex.org/W1708748675","https://openalex.org/W1787109533","https://openalex.org/W1892184508","https://openalex.org/W1963706142","https://openalex.org/W1965490050","https://openalex.org/W1965493386","https://openalex.org/W1975478837","https://openalex.org/W1976994179","https://openalex.org/W1979278926","https://openalex.org/W1983294897","https://openalex.org/W1990852282","https://openalex.org/W1991127932","https://openalex.org/W1992977906","https://openalex.org/W1993433679","https://openalex.org/W1998566879","https://openalex.org/W1999202090","https://openalex.org/W2002138267","https://openalex.org/W2002458232","https://openalex.org/W2003618903","https://openalex.org/W2007273534","https://openalex.org/W2009590767","https://openalex.org/W2010567193","https://openalex.org/W2011006768","https://openalex.org/W2013040642","https://openalex.org/W2013576210","https://openalex.org/W2015204889","https://openalex.org/W2024285102","https://openalex.org/W2027091986","https://openalex.org/W2027397693","https://openalex.org/W2030156802","https://openalex.org/W2033220681","https://openalex.org/W2039172243","https://openalex.org/W2046167310","https://openalex.org/W2048933375","https://openalex.org/W2054553613","https://openalex.org/W2056121897","https://openalex.org/W2059235432","https://openalex.org/W2060817939","https://openalex.org/W2063219607","https://openalex.org/W2071675524","https://openalex.org/W2076094855","https://openalex.org/W2084610773","https://openalex.org/W2086680736","https://openalex.org/W2091719398","https://openalex.org/W2095518569","https://openalex.org/W2096920002","https://openalex.org/W2097599737","https://openalex.org/W2100373655","https://openalex.org/W2100553420","https://openalex.org/W2107204729","https://openalex.org/W2107994524","https://openalex.org/W2108244474","https://openalex.org/W2108824686","https://openalex.org/W2109982451","https://openalex.org/W2110678596","https://openalex.org/W2113131573","https://openalex.org/W2114216755","https://openalex.org/W2121453357","https://openalex.org/W2122683221","https://openalex.org/W2124529740","https://openalex.org/W2127749087","https://openalex.org/W2133370719","https://openalex.org/W2135631468","https://openalex.org/W2136763179","https://openalex.org/W2136971069","https://openalex.org/W2143746688","https://openalex.org/W2144633571","https://openalex.org/W2145249136","https://openalex.org/W2148726348","https://openalex.org/W2150926065","https://openalex.org/W2151308994","https://openalex.org/W2152914202","https://openalex.org/W2153233330","https://openalex.org/W2155136631","https://openalex.org/W2158274719","https://openalex.org/W2158620400","https://openalex.org/W2162099891","https://openalex.org/W2168400885","https://openalex.org/W2169618838","https://openalex.org/W2171529323","https://openalex.org/W2375266061","https://openalex.org/W2438568871","https://openalex.org/W2993595994","https://openalex.org/W4313333668"],"related_works":["https://openalex.org/W2027812455","https://openalex.org/W7098396255","https://openalex.org/W3122448302","https://openalex.org/W2020193799","https://openalex.org/W2800328670","https://openalex.org/W2009974603","https://openalex.org/W3134560137","https://openalex.org/W2066355775","https://openalex.org/W2053037591","https://openalex.org/W2111106254"],"abstract_inverted_index":{"BACKGROUND:":[0],"Haemophilus":[1],"parasuis":[2],"(HPS)":[3],"is":[4,14],"an":[5],"important":[6],"swine":[7],"pathogen":[8],"that":[9,25,164,204,235,275],"causes":[10],"Gl\u00e4sser's":[11],"disease,":[12],"which":[13],"characterized":[15],"by":[16,222],"fibrinous":[17],"polyserositis,":[18],"meningitis":[19],"and":[20,101,134,145,150,156,170,180,188,243,269],"arthritis.":[21],"The":[22,104],"molecular":[23],"mechanisms":[24],"underlie":[26],"the":[27,30,36,50,57,63,79,109,249,261,264],"pathogenesis":[28],"of":[29,38,70,87,167,185,194,263],"disease":[31],"remain":[32],"poorly":[33],"understood,":[34],"particularly":[35],"resistance":[37,279],"porcine":[39,80,173,198,213],"immune":[40,110,265],"system":[41],"to":[42,153,197,260,278,280],"HPS":[43,60,85,239],"invasion.":[44],"In":[45,191],"this":[46],"study,":[47],"we":[48,270],"investigated":[49],"global":[51],"changes":[52,231],"in":[53,56,78,108,172,209,232,241,248,267],"gene":[54,233],"expression":[55,94],"spleen":[58,81],"following":[59],"infection":[61,240],"using":[62,99],"Affymetrix":[64],"Porcine":[65],"Genechip.":[66],"RESULTS:":[67],"A":[68],"total":[69],"931":[71],"differentially":[72],"expressed":[73],"(DE)":[74],"transcripts":[75],"were":[76,181,207,220],"identified":[77,247,272],"7":[82,210],"days":[83],"after":[84,183],"infection;":[86],"these,":[88],"92":[89],"unique":[90],"genes":[91,106,113,141,151,196,206,219,274],"showed":[92,203],"differential":[93],"patterns":[95],"based":[96],"on":[97],"analysis":[98],"BLASTX":[100],"Gene":[102],"Ontology.":[103],"DE":[105,195,218],"involved":[107],"response":[111,266],"included":[112],"for":[114,142],"inflammasomes":[115],"(RETN,":[116],"S100A8,":[117,168],"S100A9,":[118,169],"S100A12),":[119],"adhesion":[120],"molecules":[121],"(CLDN3,":[122],"CSPG2,":[123],"CD44,":[124],"LGALS8),":[125],"transcription":[126,234],"factors":[127],"(ZBTB16,":[128],"SLC39A14,":[129],"CEBPD,":[130],"CEBPB),":[131],"acute-phase":[132],"proteins":[133],"complement":[135],"(SAA1,":[136],"LTF,":[137],"HP,":[138],"C3),":[139],"differentiation":[140],"epithelial":[143],"cells":[144,175],"keratinocytes":[146],"(TGM1,":[147],"MS4A8B,":[148],"CSTA),":[149],"related":[152,277],"antigen":[154],"processing":[155],"presentation":[157],"(HLA-B,":[158],"HLA-DRB1).":[159],"Further":[160],"immunostimulation":[161],"analyses":[162],"indicated":[163],"mRNA":[165],"levels":[166],"S100A12":[171],"PK-15":[174],"increased":[176],"within":[177],"48":[178],"h":[179],"sustained":[182],"administration":[184],"lipopolysaccharide":[186],"(LPS)":[187],"Poly(I:C)":[189],"respectively.":[190],"addition,":[192],"mapping":[193],"health":[199],"traits":[200],"QTL":[201,214],"regions":[202],"70":[205],"distributed":[208],"different":[211],"known":[212],"regions.":[215],"Finally,":[216],"10":[217],"validated":[221],"quantitative":[223],"PCR.":[224],"CONCLUSION:":[225],"Our":[226,255],"findings":[227],"demonstrate":[228],"previously":[229],"unrecognized":[230],"are":[236,276],"associated":[237],"with":[238],"vivo,":[242],"many":[244],"potential":[245],"cascades":[246],"study":[250],"clearly":[251],"merit":[252],"further":[253],"investigation.":[254],"data":[256],"provide":[257],"new":[258],"clues":[259],"nature":[262],"mammals,":[268],"have":[271],"candidate":[273],"HPS.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}