{"id":"https://openalex.org/W2000728503","doi":"https://doi.org/10.1210/endo-128-4-2008","title":"In VivoBiological Validation and Biophysical Modeling of the Sensitivity and Positive Accuracy of Endocrine Peak Detection. II. The Follicle-Stimulating Hormone Pulse Signal*","display_name":"In VivoBiological Validation and Biophysical Modeling of the Sensitivity and Positive Accuracy of Endocrine Peak Detection. II. The Follicle-Stimulating Hormone Pulse Signal*","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2000728503","doi":"https://doi.org/10.1210/endo-128-4-2008","mag":"2000728503","pmid":"https://pubmed.ncbi.nlm.nih.gov/1900782"},"language":"en","primary_location":{"id":"doi:10.1210/endo-128-4-2008","doi":"https://doi.org/10.1210/endo-128-4-2008","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-128-4-2008","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048481221","display_name":"Randall J. Urban","orcid":"https://orcid.org/0000-0002-6492-2042","observed_orcids":["https://orcid.org/0000-0002-6492-2042"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RANDALL J. URBAN","raw_affiliation_strings":["Interdisciplinary Graduate Biophysics Program, University of Virginia Health Sciences Center, Charlottesville","University of Virginia'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Graduate Biophysics Program, University of Virginia Health Sciences Center, Charlottesville","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia'","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101704002","display_name":"Michael L. Johnson","orcid":"https://orcid.org/0000-0001-9646-2223","observed_orcids":["https://orcid.org/0000-0001-9646-2223"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL L. JOHNSON","raw_affiliation_strings":["Interdisciplinary Graduate Biophysics Program (R.J.L., J.D. V.) and the Division of Endocrinology and Metabolism, Departments of Internal Medicine and Pharmacology (M.L.J.), University of Virginia Health Sciences Center and Biodynamics Institute Charlottesville, Virginia 22908","University of Virginia'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Graduate Biophysics Program (R.J.L., J.D. V.) and the Division of Endocrinology and Metabolism, Departments of Internal Medicine and Pharmacology (M.L.J.), University of Virginia Health Sciences Center and Biodynamics Institute Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia'","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003698342","display_name":"Johannes D. Veldhuis","orcid":"https://orcid.org/0000-0002-6477-7092","observed_orcids":["https://orcid.org/0000-0002-6477-7092"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHANNES D. VELDHUIS","raw_affiliation_strings":["Interdisciplinary Graduate Biophysics Program (R.J.L., J.D. V.) and the Division of Endocrinology and Metabolism, Departments of Internal Medicine and Pharmacology (M.L.J.), University of Virginia Health Sciences Center and Biodynamics Institute Charlottesville, Virginia 22908","University of Virginia'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Graduate Biophysics Program (R.J.L., J.D. V.) and the Division of Endocrinology and Metabolism, Departments of Internal Medicine and Pharmacology (M.L.J.), University of Virginia Health Sciences Center and Biodynamics Institute Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia'","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.5517,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.94394886,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"128","issue":"4","first_page":"2008","last_page":"2014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.996999979019165},{"id":"https://openalex.org/keywords/pulsatile-hormone-secretion","display_name":"pulsatile hormone secretion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hormone-half-life","display_name":"hormone half-life","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hormone-clearance","display_name":"hormone clearance","score":0.609000027179718},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.6539999842643738},{"id":"https://openalex.org/keywords/gonadotropin-regulation","display_name":"gonadotropin regulation","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.600212574005127},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5767752528190613},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.572845995426178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5635299682617188},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.552523672580719},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.507178544998169},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.47160205245018005},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.44794726371765137},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.4393242299556732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39190128445625305},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.31695783138275146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24213209748268127},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22594943642616272},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007033","descriptor_name":"Hypothalamus, Middle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007033","descriptor_name":"Hypothalamus, Middle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007033","descriptor_name":"Hypothalamus, Middle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-128-4-2008","doi":"https://doi.org/10.1210/endo-128-4-2008","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-128-4-2008","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:1900782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1900782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G236342864","display_name":null,"funder_award_id":"3 MO1 RR 00847-1491","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2948705655","display_name":null,"funder_award_id":"RR 00847","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3152241780","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"2s07rr005431-31","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5531328711","display_name":"General Clinical Research Center","funder_award_id":"M01RR000847","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5552673955","display_name":null,"funder_award_id":"5-507-RR-05431-26","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1880023255","https://openalex.org/W1996846143","https://openalex.org/W2006219321","https://openalex.org/W2036986004","https://openalex.org/W2094719820","https://openalex.org/W2116374770","https://openalex.org/W2127420615","https://openalex.org/W2278881736","https://openalex.org/W2325256176","https://openalex.org/W2411692281","https://openalex.org/W2418166353"],"related_works":["https://openalex.org/W2159101625","https://openalex.org/W2094886651","https://openalex.org/W2129207413","https://openalex.org/W2339750048","https://openalex.org/W1991000644","https://openalex.org/W2024644536","https://openalex.org/W1900585940","https://openalex.org/W2131811017","https://openalex.org/W2113135867","https://openalex.org/W7095248940"],"abstract_inverted_index":{"Despite":[0],"interest":[1],"in":[2,4,40,49,115,120,160,243,280],"the":[3,13,17,21,28,53,70,91,103,179,242],"vivo":[5,116,244],"control":[6],"of":[7,12,16,20,33,52,57,72,79,93,108,133,174,184,256],"gonadotropin":[8,22,271],"release,":[9],"valid":[10,282],"assessment":[11],"physiological":[14],"regulation":[15],"pulsatile":[18],"secretion":[19],"FSH":[23,35,42,73,96,124,158,201,208,278],"has":[24],"been":[25],"hampered":[26],"by":[27,77,129,210],"uncertain":[29],"validity":[30,71],"and":[31,100,105,153,162,181,193,224,232,241,267,289],"reliability":[32],"available":[34],"peak":[36,109,185,190,264],"detection":[37,186,191,265],"algorithms.":[38],"Difficulties":[39],"identifying":[41],"peaks":[43,159],"accurately":[44],"are":[45],"believed":[46],"to":[47,68,143],"arise":[48],"part":[50],"because":[51],"slow":[54],"metabolic":[55],"clearance":[56],"this":[58],"glycoprotein":[59],"hormone.":[60],"Here,":[61],"we":[62,89,112],"have":[63],"used":[64,113],"two":[65,139],"complementary":[66],"strategies":[67],"test":[69],"pulse":[74,98,146],"detection.":[75,110],"First,":[76],"means":[78],"a":[80,281],"computer-assisted":[81],"mathematical":[82],"model":[83,246],"for":[84,156,187,207,277],"simulating":[85],"episodic":[86,200],"hormone":[87,175,194,257,263],"secretion,":[88],"evaluated":[90,127],"effects":[92],"various":[94],"putative":[95],"secretory":[97,195],"amplitudes":[99],"half-lives":[101],"on":[102],"sensitivity":[104,152,180,231,266],"positive":[106,154,182,226,233,268,291],"accuracy":[107,155,183,234],"Secondly,":[111],"an":[114,211],"primate":[117],"animal":[118,245],"model,":[119],"which":[121],"presumptively":[122],"true":[123],"pulses":[125],"were":[126],"independently":[128],"continuous":[130],"electrophysiological":[131],"monitoring":[132],"mediobasal":[134],"hypothalamic":[135],"multiunit":[136],"activity.":[137],"These":[138],"approaches":[140],"allowed":[141],"us":[142],"define":[144],"optimal":[145],"analysis":[147],"parameters":[148],"that":[149,171,229,253],"yield":[150],"maximal":[151],"detecting":[157],"synthetic":[161],"biological":[163],"time":[164,202,272],"series.":[165],"We":[166,251],"found":[167],"(as":[168],"predicted":[169],"intuitively)":[170],"increasing":[172,254],"half-times":[173,255],"disappearance":[176],"decrease":[177],"both":[178],"any":[188],"given":[189],"thresholds":[192],"amplitudes.":[196],"However,":[197],"adequately":[198,285],"sampled":[199],"series":[203,273],"could":[204],"be":[205,275],"analyzed":[206,276],"pulsatility":[209,279],"appropriately":[212],"constrained,":[213],"objective":[214],"computerized":[215],"algorithm":[216],"with":[217,284],"reasonable":[218],"(less":[219],"than":[220],"10-15%)":[221],"false":[222,225,287,290],"negative":[223,288],"errors,":[227],"such":[228],"resultant":[230],"exceed":[235],"85-90%.":[236],"Of":[237],"interest,":[238],"computer":[239],"simulations":[240],"exhibited":[247],"similar":[248],"discriminative":[249],"capabilities.":[250],"conclude":[252],"(e.g.":[258],"FSH)":[259],"removal":[260],"do":[261],"impair":[262],"accuracy.":[269],"Nevertheless,":[270],"can":[274],"manner":[283],"constrained":[286],"error":[292],"rates.":[293]},"counts_by_year":[{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
