{"id":"https://openalex.org/W2000728270","doi":"https://doi.org/10.4161/cc.9.3.10606","title":"KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription","display_name":"KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W2000728270","doi":"https://doi.org/10.4161/cc.9.3.10606","mag":"2000728270","pmid":"https://pubmed.ncbi.nlm.nih.gov/20107328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2888133"},"language":"en","primary_location":{"id":"doi:10.4161/cc.9.3.10606","doi":"https://doi.org/10.4161/cc.9.3.10606","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.3.10606","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.3.10606?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.3.10606?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019426711","display_name":"Alison M. Urvalek","orcid":"https://orcid.org/0009-0004-9914-1328","observed_orcids":["https://orcid.org/0009-0004-9914-1328"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Urvalek","raw_affiliation_strings":["Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY, USA","Center for Cell Biology & Cancer Research; Albany Medical College; Albany, NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY, USA","institution_ids":["https://openalex.org/I4405260259"]},{"raw_affiliation_string":"Center for Cell Biology & Cancer Research; Albany Medical College; Albany, NY USA","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100601692","display_name":"Xianhui Wang","orcid":"https://orcid.org/0000-0002-8732-829X","observed_orcids":["https://orcid.org/0000-0002-8732-829X"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianhui Wang","raw_affiliation_strings":["Center for Cell Biology and Cancer Research ; Albany Medical College ; Albany , NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Biology and Cancer Research ; Albany Medical College ; Albany , NY USA","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Heng Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng Lu","raw_affiliation_strings":["Center for Cell Biology and Cancer Research ; Albany Medical College ; Albany , NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Biology and Cancer Research ; Albany Medical College ; Albany , NY USA","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111558780","display_name":"Jihe Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jihe Zhao","raw_affiliation_strings":["Center for Cell Biology and Cancer Research ; Albany Medical College ; Albany , NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Biology and Cancer Research ; Albany Medical College ; Albany , NY USA","institution_ids":["https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111558780"],"corresponding_institution_ids":["https://openalex.org/I4405260259"],"apc_list":null,"apc_paid":null,"fwci":2.7342,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.904015,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"3","first_page":"601","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klf8","display_name":"KLF8","score":0.972000002861023},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.7929999828338623},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pcaf","display_name":"PCAF","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cbp","display_name":"CBP","score":0.8830000162124634},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.734000027179718},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.734000027179718},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C107793267","wikidata":"https://www.wikidata.org/wiki/Q14908260","display_name":"PCAF","level":4,"score":0.888349711894989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7118706107139587},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.7087364792823792},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.6344048380851746},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5390282273292542},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5281182527542114},{"id":"https://openalex.org/C2911110750","wikidata":"https://www.wikidata.org/wiki/Q7117884","display_name":"P300-CBP Transcription Factors","level":5,"score":0.5130995512008667},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.47241511940956116},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.46564778685569763},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.4543142318725586},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.453857958316803},{"id":"https://openalex.org/C2778001298","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone acetyltransferase","level":4,"score":0.42986732721328735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4152776598930359},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.41200539469718933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38419845700263977},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3789220154285431},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28744757175445557},{"id":"https://openalex.org/C2910921701","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone Acetyltransferases","level":4,"score":0.15945884585380554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14742085337638855},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099224","descriptor_name":"p300-CBP-Associated Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050881","descriptor_name":"E1A-Associated p300 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.9.3.10606","doi":"https://doi.org/10.4161/cc.9.3.10606","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.3.10606","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.3.10606?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:20107328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20107328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2888133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2888133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Cycle","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/cc.9.3.10606","doi":"https://doi.org/10.4161/cc.9.3.10606","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.3.10606","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.3.10606?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2518665210","display_name":"KLF8 Regulation of EMT Tumor Metastasis","funder_award_id":"R01CA132977","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7958929281","display_name":null,"funder_award_id":"CA132977","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000728270.pdf","grobid_xml":"https://content.openalex.org/works/W2000728270.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1643056575","https://openalex.org/W1966063731","https://openalex.org/W1970422890","https://openalex.org/W1979647722","https://openalex.org/W1982336595","https://openalex.org/W1985063313","https://openalex.org/W1998101963","https://openalex.org/W2000952960","https://openalex.org/W2002716147","https://openalex.org/W2004520528","https://openalex.org/W2010850546","https://openalex.org/W2012318525","https://openalex.org/W2022532021","https://openalex.org/W2023610294","https://openalex.org/W2024013245","https://openalex.org/W2030571655","https://openalex.org/W2030610316","https://openalex.org/W2033159340","https://openalex.org/W2036018178","https://openalex.org/W2037653294","https://openalex.org/W2041705439","https://openalex.org/W2044383852","https://openalex.org/W2046801755","https://openalex.org/W2048924213","https://openalex.org/W2055236991","https://openalex.org/W2056801328","https://openalex.org/W2059035317","https://openalex.org/W2061100496","https://openalex.org/W2074469807","https://openalex.org/W2079102916","https://openalex.org/W2085206941","https://openalex.org/W2089166549","https://openalex.org/W2095217266","https://openalex.org/W2095358593","https://openalex.org/W2135501426","https://openalex.org/W2138696495","https://openalex.org/W2144720355","https://openalex.org/W2166871205"],"related_works":["https://openalex.org/W2374306541","https://openalex.org/W2055181642","https://openalex.org/W2260365559","https://openalex.org/W2135501426","https://openalex.org/W2045019295","https://openalex.org/W1982336595","https://openalex.org/W2023610294","https://openalex.org/W2002716147","https://openalex.org/W2022532021","https://openalex.org/W2108048093"],"abstract_inverted_index":{"Kr\u00fcppel-like":[0],"factor":[1],"8":[2],"(KLF8)":[3],"regulates":[4],"critical":[5],"cellular":[6],"processes":[7],"including":[8],"cell":[9],"cycle":[10],"progression,":[11],"transformation,":[12],"epithelial-to-mesenchymal":[13],"transition,":[14],"migration":[15],"and":[16,61,67,77,106,208,215],"invasion":[17],"by":[18,110],"either":[19],"repressing":[20],"or":[21,88,103,113],"activating":[22],"target":[23,219],"gene":[24,220],"promoters.":[25],"As":[26],"a":[27,150],"repressor,":[28],"KLF8":[29,41,58,93,122,138,162,197],"recruits":[30],"the":[31,53,57,128,143,146,163,180,185,196,205],"CtBP":[32],"co-repressor":[33],"via":[34],"its":[35],"PVDLS":[36],"repression":[37],"motif.":[38],"However,":[39],"how":[40],"acts":[42],"as":[43],"an":[44],"activator":[45],"has":[46],"not":[47,116],"been":[48],"determined.":[49],"Here":[50],"we":[51,81],"report":[52],"identification":[54],"of":[55,85,90,153],"both":[56,74],"activation":[59,198],"domain":[60,199],"associated":[62],"co-activators.":[63],"By":[64],"site-directed":[65],"mutagenesis":[66],"cyclin":[68,171],"D1":[69,172],"promoter":[70,144],"reporter":[71],"assays":[72,177],"using":[73],"mouse":[75],"fibroblasts":[76],"human":[78],"epithelial":[79],"cells,":[80],"determined":[82],"that":[83,121,137,159,179],"deletion":[84],"residues":[86,202],"100-260":[87],"mutation":[89],"Q118-Q248":[91],"abolished":[92],"transactivity.":[94],"this":[95,154],"transactivity":[96],"was":[97,165],"dramatically":[98],"reduced":[99],"in":[100],"p300(-/-),":[101],"CBP(-/-)":[102],"PCAF(-/-)":[104],"cells":[105],"could":[107],"be":[108],"restored":[109],"re-expressing":[111],"p300":[112,214],"PCAF,":[114],"but":[115],"CBP.":[117],"Co-immunoprecipitation":[118],"analyses":[119],"demonstrated":[120],"interacted":[123],"with":[124],"these":[125,193],"co-activators":[126],"whereas":[127,145],"Q118N-Q248N":[129,147,164,181],"mutant":[130,148,182],"did":[131],"not.":[132],"Chromatin":[133],"immunoprecipitation":[134],"experiments":[135],"showed":[136,178],"promoted":[139],"histone":[140],"acetylation":[141],"at":[142],"had":[149],"dramatic":[151],"loss":[152],"function.":[155],"Western":[156],"blotting":[157],"revealed":[158],"unlike":[160],"wild-type":[161],"no":[166],"longer":[167],"able":[168],"to":[169,187,217],"upregulate":[170],"protein":[173],"level.":[174],"BrdU":[175],"incorporation":[176],"also":[183],"lost":[184],"ability":[186],"promote":[188],"DNA":[189],"synthesis.":[190],"Taken":[191],"together,":[192],"results":[194],"identified":[195],"located":[200],"between":[201],"101-260":[203],"where":[204],"well-conserved":[206],"Q118":[207],"Q248":[209],"are":[210],"essential":[211],"for":[212],"recruiting":[213],"PCAF":[216],"activate":[218],"transcription.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
