{"id":"https://openalex.org/W2000719263","doi":"https://doi.org/10.1001/archopht.1959.04220030026005","title":"Hypophysectomy as a Therapeutical Method for Proliferative Diabetic Retinopathy","display_name":"Hypophysectomy as a Therapeutical Method for Proliferative Diabetic Retinopathy","publication_year":1959,"publication_date":"1959-09-01","ids":{"openalex":"https://openalex.org/W2000719263","doi":"https://doi.org/10.1001/archopht.1959.04220030026005","mag":"2000719263","pmid":"https://pubmed.ncbi.nlm.nih.gov/13841255"},"language":"en","primary_location":{"id":"doi:10.1001/archopht.1959.04220030026005","doi":"https://doi.org/10.1001/archopht.1959.04220030026005","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archopht.1959.04220030026005","pdf_url":null,"source":{"id":"https://openalex.org/S80523760","display_name":"Archives of Ophthalmology","issn_l":"0003-9950","issn":["0003-9950","1538-3601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007092931","display_name":"Salme Vannas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. VANNAS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055816214","display_name":"C. A. Hernberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. A. HERNBERG","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002686720","display_name":"G. af Bj\u00f6rkesten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. af BJORKESTEN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9565,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.93530702,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"3","first_page":"370","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.921999990940094},{"id":"https://openalex.org/keywords/proliferative-diabetic-retinopathy","display_name":"proliferative diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8799999952316284},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9049999713897705},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.5770000219345093},{"id":"https://openalex.org/keywords/retinal-hemorrhage","display_name":"retinal hemorrhage","score":0.6940000057220459},{"id":"https://openalex.org/keywords/blindness","display_name":"blindness","score":0.5519999861717224},{"id":"https://openalex.org/keywords/secondary-glaucoma","display_name":"secondary glaucoma","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.787002682685852},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.7628785967826843},{"id":"https://openalex.org/C2780104272","wikidata":"https://www.wikidata.org/wiki/Q933496","display_name":"Hypophysectomy","level":3,"score":0.721330463886261},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6573859453201294},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.6572121381759644},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.5715045928955078},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.512461245059967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46351635456085205},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4575336277484894},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.44135695695877075},{"id":"https://openalex.org/C2780485761","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Blood sugar","level":3,"score":0.44130170345306396},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.36579468846321106},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.35621196031570435},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3380391597747803}],"mesh":[{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archopht.1959.04220030026005","doi":"https://doi.org/10.1001/archopht.1959.04220030026005","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archopht.1959.04220030026005","pdf_url":null,"source":{"id":"https://openalex.org/S80523760","display_name":"Archives of Ophthalmology","issn_l":"0003-9950","issn":["0003-9950","1538-3601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:13841255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13841255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of ophthalmology (Chicago, Ill. : 1960)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1968613663","https://openalex.org/W1980184609","https://openalex.org/W1995261763","https://openalex.org/W1996154589","https://openalex.org/W2023474785","https://openalex.org/W2044944092","https://openalex.org/W2082730746","https://openalex.org/W2321130184","https://openalex.org/W2441797173","https://openalex.org/W2769849122","https://openalex.org/W3087485246"],"related_works":["https://openalex.org/W2019358423","https://openalex.org/W2316420987","https://openalex.org/W2429745413","https://openalex.org/W2405616400","https://openalex.org/W2414752006","https://openalex.org/W4230044768","https://openalex.org/W2418568708","https://openalex.org/W2416059025","https://openalex.org/W2409791706","https://openalex.org/W2441286915"],"abstract_inverted_index":{"Proliferative":[0],"diabetic":[1,113,145],"retinopathy":[2,114,146],"occurs":[3],"as":[4],"a":[5],"dreaded":[6],"complication":[7],"of":[8,78,112,127],"labile":[9],"juvenile":[10],"diabetes":[11,143],"difficult":[12],"to":[13,51,90,93],"control":[14],"with":[15,117],"insulin.":[16],"Prophylactically":[17],"and":[18,24,27,30,43,45,105,144],"therapeutically":[19],"the":[20,36,53,57,64,71,76,97,110,125,128,131,135],"blood":[21],"sugar,":[22],"fluid":[23],"electrolyte":[25],"balance,":[26],"corticotropin":[28],"(ACTH)":[29],"corticosteroid":[31],"activity":[32],"must":[33],"be":[34,124],"controlled.19Among":[35],"drugs":[37],"employed":[38],"are":[39],"cyanocobalamin":[40],"(vitamin":[41],"B12)":[42],"antifragility":[44],"lipotropic":[46],"substances.6,11,15,19It":[47],"is":[48,115,139],"sometimes":[49],"possible":[50,140],"delay":[52],"disease,":[54],"especially":[55],"in":[56],"incipient":[58],"phase,":[59],"for":[60],"years":[61],"even.":[62],"When":[63],"proliferative":[65],"process":[66],"has":[67],"burst":[68],"out,":[69],"however,":[70],"cure":[72],"or":[73,88],"at":[74],"least":[75],"prevention":[77],"its":[79],"progress":[80],"often":[81],"fails,":[82],"unfortunately.":[83],"Recurrent":[84],"hemorrhages":[85],"lead":[86],"sooner":[87],"later":[89],"incurable":[91],"blindness\u2014and":[92],"painful":[94],"secondary":[95],"glaucoma\u2014if":[96],"patient":[98],"lives":[99],"long":[100],"enough.":[101],"Numerous":[102],"experimental":[103],"observations":[104],"clinical":[106],"investigations":[107],"show":[108],"that":[109,141],"development":[111],"associated":[116],"adrenal":[118,132],"cortical":[119],"hyperfunction":[120],"which":[121],"may":[122],"even":[123],"cause":[126],"retinopathy.5-7,9Hypophysectomy":[129],"reduces":[130],"function.":[133],"On":[134],"other":[136],"hand,":[137],"it":[138],"both":[142]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}