{"id":"https://openalex.org/W2000712658","doi":"https://doi.org/10.1016/0047-6374(84)90116-7","title":"Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat","display_name":"Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat","publication_year":1984,"publication_date":"1984-03-01","ids":{"openalex":"https://openalex.org/W2000712658","doi":"https://doi.org/10.1016/0047-6374(84)90116-7","mag":"2000712658","pmid":"https://pubmed.ncbi.nlm.nih.gov/6717094"},"language":"en","primary_location":{"id":"doi:10.1016/0047-6374(84)90116-7","doi":"https://doi.org/10.1016/0047-6374(84)90116-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0047-6374(84)90116-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/0047637484901167","source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/0047637484901167","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087227112","display_name":"Robert E. Beyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert E. Beyer","raw_affiliation_strings":["Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063248134","display_name":"Joseph W. Starnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph W. Starnes","raw_affiliation_strings":["Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111997987","display_name":"Dee W. Edington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dee W. Edington","raw_affiliation_strings":["Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard J. Lipton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Lipton","raw_affiliation_strings":["Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ralph T. Compton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph T. Compton","raw_affiliation_strings":["Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024847017","display_name":"Michael A. Kwasman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Kwasman","raw_affiliation_strings":["Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"The Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109 U.S.A","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087227112"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.4711,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.81591885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"3","first_page":"309","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5879999995231628},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.5799999833106995},{"id":"https://openalex.org/keywords/endurance-training","display_name":"endurance training","score":0.9449999928474426},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7860000133514404},{"id":"https://openalex.org/keywords/oxidative-capacity","display_name":"oxidative capacity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/flavin","display_name":"flavin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/succinate-oxidation","display_name":"succinate oxidation","score":0.718999981880188},{"id":"https://openalex.org/keywords/treadmill-running","display_name":"treadmill running","score":0.6940000057220459},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.890999972820282},{"id":"https://openalex.org/keywords/quadriceps","display_name":"quadriceps","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mitochondrial-fractionation","display_name":"mitochondrial fractionation","score":0.5410000085830688},{"id":"https://openalex.org/keywords/age-related-decline","display_name":"age-related decline","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7432750463485718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.629204511642456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6094701290130615},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5096194744110107},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.48636892437934875},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4728691279888153},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4627070426940918},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.44630545377731323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4013154208660126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3821653127670288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3520318865776062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2878503203392029},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005415","descriptor_name":"Flavins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0047-6374(84)90116-7","doi":"https://doi.org/10.1016/0047-6374(84)90116-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0047-6374(84)90116-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/0047637484901167","source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},{"id":"pmid:6717094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6717094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of ageing and development","raw_type":"Comparative Study"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/24891","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/24891","pdf_url":"https://hdl.handle.net/2027.42/24891","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/0047-6374(84)90116-7","doi":"https://doi.org/10.1016/0047-6374(84)90116-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0047-6374(84)90116-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/0047637484901167","source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000712658.pdf","grobid_xml":"https://content.openalex.org/works/W2000712658.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W15720585","https://openalex.org/W37702950","https://openalex.org/W44213714","https://openalex.org/W51487972","https://openalex.org/W967187318","https://openalex.org/W982953202","https://openalex.org/W1485250221","https://openalex.org/W1511854000","https://openalex.org/W1542197083","https://openalex.org/W1566830427","https://openalex.org/W1575149124","https://openalex.org/W1615913434","https://openalex.org/W1775749144","https://openalex.org/W1841162023","https://openalex.org/W1873997628","https://openalex.org/W1965689373","https://openalex.org/W1968024017","https://openalex.org/W1972607755","https://openalex.org/W1974201116","https://openalex.org/W1977815102","https://openalex.org/W1982723225","https://openalex.org/W1996643604","https://openalex.org/W2005047261","https://openalex.org/W2005745170","https://openalex.org/W2011951281","https://openalex.org/W2012372243","https://openalex.org/W2015717515","https://openalex.org/W2033666575","https://openalex.org/W2046479235","https://openalex.org/W2048192762","https://openalex.org/W2049608820","https://openalex.org/W2055329241","https://openalex.org/W2059639887","https://openalex.org/W2070417487","https://openalex.org/W2073298353","https://openalex.org/W2078048660","https://openalex.org/W2296239031","https://openalex.org/W2297499198","https://openalex.org/W2307735155","https://openalex.org/W2315184754","https://openalex.org/W2321504714","https://openalex.org/W2322612078","https://openalex.org/W2330148479","https://openalex.org/W2396331935","https://openalex.org/W2409016876","https://openalex.org/W2735482738","https://openalex.org/W4253437772","https://openalex.org/W6602102901","https://openalex.org/W6639134976"],"related_works":["https://openalex.org/W7098923261","https://openalex.org/W2261817486","https://openalex.org/W2315184754","https://openalex.org/W2045301111","https://openalex.org/W3174320682","https://openalex.org/W1981651993","https://openalex.org/W2089962035","https://openalex.org/W1482036488","https://openalex.org/W1982362310","https://openalex.org/W2021506091"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}