{"id":"https://openalex.org/W2000709179","doi":"https://doi.org/10.1016/s0960-9822(01)00663-7","title":"Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6","display_name":"Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2000709179","doi":"https://doi.org/10.1016/s0960-9822(01)00663-7","mag":"2000709179","pmid":"https://pubmed.ncbi.nlm.nih.gov/11839275"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-9822(01)00663-7","doi":"https://doi.org/10.1016/s0960-9822(01)00663-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0960-9822(01)00663-7","pdf_url":"http://www.cell.com/article/S0960982201006637/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000709179"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0960982201006637/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083753621","display_name":"Lin Gao","orcid":"https://orcid.org/0000-0002-1781-4671","observed_orcids":["https://orcid.org/0000-0002-1781-4671"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Gao","raw_affiliation_strings":["Center for Cell Signaling and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908-0577, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Signaling and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908-0577, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007973212","display_name":"G\u00e9rard Joberty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G\u00e9rard Joberty","raw_affiliation_strings":["Center for Cell Signaling and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908-0577, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Signaling and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908-0577, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002460941","display_name":"Ian G. Macara","orcid":"https://orcid.org/0000-0001-8546-5357","observed_orcids":["https://orcid.org/0000-0001-8546-5357"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ian G. Macara","raw_affiliation_strings":["Center for Cell Signaling and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908-0577, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Signaling and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908-0577, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002460941"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":14.8596,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.99664862,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"3","first_page":"221","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tight-junction-assembly","display_name":"tight junction assembly","score":0.9860000014305115},{"id":"https://openalex.org/keywords/par6","display_name":"Par6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apicobasal-polarity","display_name":"apical-basal polarity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pkc-zeta","display_name":"PKC zeta","score":0.8050000071525574},{"id":"https://openalex.org/keywords/crib-domain","display_name":"CRIB domain","score":0.8820000290870667},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mdck-ii-cells","display_name":"MDCK II cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.8539999723434448},{"id":"https://openalex.org/keywords/paracellular-diffusion","display_name":"paracellular diffusion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/claudins","display_name":"claudins","score":0.6190000176429749},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.781000018119812},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/atypical-protein-kinase-c","display_name":"atypical protein kinase C","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.8021867275238037},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.7264024615287781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.715613603591919},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6327646970748901},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.585045576095581},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.5462604761123657},{"id":"https://openalex.org/C51872919","wikidata":"https://www.wikidata.org/wiki/Q420863","display_name":"Claudin","level":3,"score":0.5280022621154785},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5070939064025879},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.45994681119918823},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33570659160614014},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3113144040107727},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11894059181213379},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099221","descriptor_name":"Protein Kinase C zeta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-9822(01)00663-7","doi":"https://doi.org/10.1016/s0960-9822(01)00663-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0960-9822(01)00663-7","pdf_url":"http://www.cell.com/article/S0960982201006637/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:11839275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11839275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0960-9822(01)00663-7","doi":"https://doi.org/10.1016/s0960-9822(01)00663-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0960-9822(01)00663-7","pdf_url":"http://www.cell.com/article/S0960982201006637/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4268782045","display_name":"Signal Transduction in Time and Space","funder_award_id":"P01CA040042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2000709179.pdf"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W91824008","https://openalex.org/W1538303836","https://openalex.org/W1560056935","https://openalex.org/W1595817144","https://openalex.org/W1990557148","https://openalex.org/W2024349959","https://openalex.org/W2040531646","https://openalex.org/W2040916665","https://openalex.org/W2046013104","https://openalex.org/W2056986410","https://openalex.org/W2077792958","https://openalex.org/W2082595075","https://openalex.org/W2095718486","https://openalex.org/W2100483442","https://openalex.org/W2103831817","https://openalex.org/W2106500404","https://openalex.org/W2107601924","https://openalex.org/W2114895224","https://openalex.org/W2137261534","https://openalex.org/W2147285856","https://openalex.org/W2148250428","https://openalex.org/W2159255277","https://openalex.org/W2171761187"],"related_works":["https://openalex.org/W1560056935","https://openalex.org/W1966422947","https://openalex.org/W1977245174","https://openalex.org/W2009671571","https://openalex.org/W2379116122","https://openalex.org/W2150019612","https://openalex.org/W2137506447","https://openalex.org/W2110267612","https://openalex.org/W2091000930"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
